format-version: 1.2 subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_agr "AGR slim" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_chembl "ChEMBL protein targets summary" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_mouse "Mouse GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_synapse "synapse GO slim" subsetdef: goslim_yeast "Yeast GO slim" synonymtypedef: syngo_official_label "label approved by the SynGO project" synonymtypedef: systematic_synonym "Systematic synonym" EXACT ontology: go/subsets/goslim_chembl [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] subset: goslim_chembl synonym: "SNAP receptor binding" EXACT [] xref: Reactome:REACT_100180 "Acetylcholine synaptic vesicle docking and priming, Rattus norvegicus" xref: Reactome:REACT_101078 "Noradrenalin synaptic vesicle docking and priming, Canis familiaris" xref: Reactome:REACT_103740 "Acetylcholine synaptic vesicle docking and priming, Canis familiaris" xref: Reactome:REACT_105540 "Vamp7 associated Lysosome to Plasma membrane transport, Mus musculus" xref: Reactome:REACT_106347 "release of L-Glutamate at the synapse, Canis familiaris" xref: Reactome:REACT_107235 "Vamp2 associated secretory vesicle to plasma membrane transport, Dictyostelium discoideum" xref: Reactome:REACT_107965 "Noradrenalin synaptic vesicle docking and priming, Mus musculus" xref: Reactome:REACT_109894 "Vamp7 associated Lysosome to Plasma membrane transport, Dictyostelium discoideum" xref: Reactome:REACT_110250 "Vamp2 associated secretory vesicle to plasma membrane transport, Canis familiaris" xref: Reactome:REACT_110371 "Release of noradrenaline at the synapse, Rattus norvegicus" xref: Reactome:REACT_110396 "Vamp7 associated Lysosome to Plasma membrane transport, Xenopus tropicalis" xref: Reactome:REACT_112169 "Acetylcholine synaptic vesicle docking and priming, Caenorhabditis elegans" xref: Reactome:REACT_112728 "Release of noradrenaline at the synapse, Caenorhabditis elegans" xref: Reactome:REACT_113606 "Glutamate synaptic vesicle docking and priming, Caenorhabditis elegans" xref: Reactome:REACT_113753 "Exocytosis of Insulin, Danio rerio" xref: Reactome:REACT_114225 "Noradrenalin synaptic vesicle docking and priming, Gallus gallus" xref: Reactome:REACT_114547 "Noradrenalin synaptic vesicle docking and priming, Caenorhabditis elegans" xref: Reactome:REACT_115054 "release of L-Glutamate at the synapse, Xenopus tropicalis" xref: Reactome:REACT_115130 "Acetylcholine synaptic vesicle docking and priming, Gallus gallus" xref: Reactome:REACT_115353 "Release of acetylcholine at the synapse, Xenopus tropicalis" xref: Reactome:REACT_12411 "release of L-Glutamate at the synapse, Homo sapiens" xref: Reactome:REACT_12617 "Glutamate synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_14778 "Vamp7 associated Lysosome to Plasma membrane transport, Homo sapiens" xref: Reactome:REACT_14821 "Vamp8 associated secretory vesicle to plasma membrane transport, Homo sapiens" xref: Reactome:REACT_14822 "Vamp2 associated secretory vesicle to plasma membrane transport, Homo sapiens" xref: Reactome:REACT_15326 "Exocytosis of Insulin, Homo sapiens" xref: Reactome:REACT_15338 "Serotonin loaded synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_15404 "Release of acetylcholine at the synapse, Homo sapiens" xref: Reactome:REACT_15411 "Noradrenalin synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_15448 "Release of noradrenaline at the synapse, Homo sapiens" xref: Reactome:REACT_15483 "Acetylcholine synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_15503 "Release of docked serotonin loaded synaptic vesicle, Homo sapiens" xref: Reactome:REACT_15517 "Dopamine synaptic vesicle docking and priming, Homo sapiens" xref: Reactome:REACT_15533 "Release of docked dopamine loaded synaptic vesicle, Homo sapiens" xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens" xref: Reactome:REACT_23813 "Release of GABA at the synapse, Homo sapiens" xref: Reactome:REACT_23973 "GABA loaded synaptic vesicle Docking and Priming, Homo sapiens" xref: Reactome:REACT_29535 "Acetylcholine synaptic vesicle docking and priming, Danio rerio" xref: Reactome:REACT_31215 "Exocytosis of Insulin, Rattus norvegicus" xref: Reactome:REACT_31588 "Vamp2 associated secretory vesicle to plasma membrane transport, Danio rerio" xref: Reactome:REACT_34035 "Vamp2 associated secretory vesicle to plasma membrane transport, Mus musculus" xref: Reactome:REACT_77361 "Vamp2 associated secretory vesicle to plasma membrane transport, Sus scrofa" xref: Reactome:REACT_77506 "Glutamate synaptic vesicle docking and priming, Danio rerio" xref: Reactome:REACT_77785 "Vamp7 associated Lysosome to Plasma membrane transport, Danio rerio" xref: Reactome:REACT_77831 "release of L-Glutamate at the synapse, Mus musculus" xref: Reactome:REACT_79299 "Glutamate synaptic vesicle docking and priming, Mus musculus" xref: Reactome:REACT_80371 "Vamp2 associated secretory vesicle to plasma membrane transport, Bos taurus" xref: Reactome:REACT_82023 "Acetylcholine synaptic vesicle docking and priming, Mus musculus" xref: Reactome:REACT_82703 "Vamp7 associated Lysosome to Plasma membrane transport, Canis familiaris" xref: Reactome:REACT_83226 "Glutamate synaptic vesicle docking and priming, Rattus norvegicus" xref: Reactome:REACT_84308 "Release of noradrenaline at the synapse, Canis familiaris" xref: Reactome:REACT_84628 "Exocytosis of Insulin, Xenopus tropicalis" xref: Reactome:REACT_87193 "Glutamate synaptic vesicle docking and priming, Canis familiaris" xref: Reactome:REACT_87411 "Vamp8 associated secretory vesicle to plasma membrane transport, Canis familiaris" xref: Reactome:REACT_87768 "Vamp2 associated secretory vesicle to plasma membrane transport, Xenopus tropicalis" xref: Reactome:REACT_90536 "Vamp7 associated Lysosome to Plasma membrane transport, Arabidopsis thaliana" xref: Reactome:REACT_92466 "Vamp8 associated secretory vesicle to plasma membrane transport, Bos taurus" xref: Reactome:REACT_93575 "Release of acetylcholine at the synapse, Rattus norvegicus" xref: Reactome:REACT_93655 "Release of acetylcholine at the synapse, Canis familiaris" xref: Reactome:REACT_93705 "Noradrenalin synaptic vesicle docking and priming, Rattus norvegicus" xref: Reactome:REACT_94126 "Vamp8 associated secretory vesicle to plasma membrane transport, Danio rerio" xref: Reactome:REACT_94434 "Exocytosis of Insulin, Bos taurus" xref: Reactome:REACT_95323 "Vamp7 associated Lysosome to Plasma membrane transport, Oryza sativa" xref: Reactome:REACT_96543 "Glutamate synaptic vesicle docking and priming, Xenopus tropicalis" xref: Reactome:REACT_96609 "release of L-Glutamate at the synapse, Rattus norvegicus" xref: Reactome:REACT_96753 "Acetylcholine synaptic vesicle docking and priming, Xenopus tropicalis" xref: Reactome:REACT_96842 "Vamp8 associated secretory vesicle to plasma membrane transport, Mus musculus" xref: Reactome:REACT_97101 "Exocytosis of Insulin, Canis familiaris" xref: Reactome:REACT_98480 "Noradrenalin synaptic vesicle docking and priming, Xenopus tropicalis" xref: Reactome:REACT_98819 "Noradrenalin synaptic vesicle docking and priming, Danio rerio" xref: Reactome:REACT_99501 "Release of noradrenaline at the synapse, Mus musculus" is_a: GO:0005515 ! protein binding [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant is_a: GO:0003674 ! molecular_function [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function alt_id: GO:0008665 def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] subset: goslim_chembl synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phosphotransferase activity" BROAD [] synonym: "Tpt1" RELATED [EC:2.7.1.160] synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: MetaCyc:2.7.1.160-RXN is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cytoplasmic interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process alt_id: GO:0007067 def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: Reactome:REACT_100451 "Cell Cycle, Mitotic, Taeniopygia guttata" xref: Reactome:REACT_104035 "Cell Cycle, Mitotic, Sus scrofa" xref: Reactome:REACT_104195 "Cell Cycle, Mitotic, Canis familiaris" xref: Reactome:REACT_105856 "Cell Cycle, Mitotic, Danio rerio" xref: Reactome:REACT_108233 "Cell Cycle, Mitotic, Saccharomyces cerevisiae" xref: Reactome:REACT_152 "Cell Cycle, Mitotic, Homo sapiens" xref: Reactome:REACT_28464 "Cell Cycle, Mitotic, Xenopus tropicalis" xref: Reactome:REACT_28953 "Cell Cycle, Mitotic, Bos taurus" xref: Reactome:REACT_33388 "Cell Cycle, Mitotic, Rattus norvegicus" xref: Reactome:REACT_53493 "Cell Cycle, Mitotic, Plasmodium falciparum" xref: Reactome:REACT_79085 "Cell Cycle, Mitotic, Schizosaccharomyces pombe" xref: Reactome:REACT_84794 "Cell Cycle, Mitotic, Caenorhabditis elegans" xref: Reactome:REACT_85137 "Cell Cycle, Mitotic, Gallus gallus" xref: Reactome:REACT_85950 "Cell Cycle, Mitotic, Arabidopsis thaliana" xref: Reactome:REACT_90332 "Cell Cycle, Mitotic, Mus musculus" xref: Reactome:REACT_90846 "Cell Cycle, Mitotic, Oryza sativa" xref: Reactome:REACT_96281 "Cell Cycle, Mitotic, Drosophila melanogaster" xref: Reactome:REACT_97744 "Cell Cycle, Mitotic, Dictyostelium discoideum" xref: Reactome:REACT_98208 "Cell Cycle, Mitotic, Mycobacterium tuberculosis" xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0140014 ! mitotic nuclear division relationship: has_part GO:0140014 ! mitotic nuclear division [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0001515 name: opioid peptide activity namespace: molecular_function def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0001517 name: N-acetylglucosamine 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] subset: goslim_chembl synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001540 name: amyloid-beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor." [GOC:hjd] subset: goslim_chembl synonym: "beta-amyloid binding" EXACT [] is_a: GO:0042277 ! peptide binding [Term] id: GO:0001618 name: virus receptor activity namespace: molecular_function def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] subset: goslim_chembl synonym: "viral receptor activity" EXACT [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0044403 ! symbiont process [Term] id: GO:0001968 name: fibronectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022. subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0008150 ! biological_process [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant is_a: GO:0003674 ! molecular_function [Term] id: GO:0003677 name: DNA binding namespace: molecular_function alt_id: GO:0043566 def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] synonym: "structure specific DNA binding" RELATED [] synonym: "structure-specific DNA binding" RELATED [] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "lamin/chromatin binding" BROAD [] synonym: "microtubule/chromatin interaction" RELATED [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0003700 name: DNA-binding transcription factor activity namespace: molecular_function alt_id: GO:0000130 alt_id: GO:0001071 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] comment: Changed definition see https://github.com/geneontology/go-ontology/issues/15704 subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "DNA binding transcription factor activity" EXACT [] synonym: "gene-specific transcription factor activity" EXACT [] synonym: "nucleic acid binding transcription factor activity" BROAD [] synonym: "sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "transcription factor activity" BROAD [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008150 ! biological_process created_by: kchris creation_date: 2010-10-21T04:37:54Z [Term] id: GO:0003723 name: RNA binding namespace: molecular_function alt_id: GO:0044822 def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "poly(A) RNA binding" RELATED [] synonym: "poly(A)-RNA binding" RELATED [] synonym: "poly-A RNA binding" RELATED [] xref: Reactome:REACT_101703 "Exportin-5 recognizes 3' overhang of pre-miRNA, Xenopus tropicalis" xref: Reactome:REACT_103323 "Exportin-5 recognizes 3' overhang of pre-miRNA, Dictyostelium discoideum" xref: Reactome:REACT_106430 "Exportin-5 recognizes 3' overhang of pre-miRNA, Mus musculus" xref: Reactome:REACT_107757 "Exportin-5 recognizes 3' overhang of pre-miRNA, Drosophila melanogaster" xref: Reactome:REACT_108232 "Exportin-5 recognizes 3' overhang of pre-miRNA, Oryza sativa" xref: Reactome:REACT_108368 "Exportin-5 recognizes 3' overhang of pre-miRNA, Saccharomyces cerevisiae" xref: Reactome:REACT_109723 "Exportin-5 recognizes 3' overhang of pre-miRNA, Arabidopsis thaliana" xref: Reactome:REACT_12458 "Exportin-5 recognizes 3' overhang of pre-miRNA, Homo sapiens" xref: Reactome:REACT_29965 "Exportin-5 recognizes 3' overhang of pre-miRNA, Canis familiaris" xref: Reactome:REACT_77167 "Exportin-5 recognizes 3' overhang of pre-miRNA, Gallus gallus" xref: Reactome:REACT_78197 "Exportin-5 recognizes 3' overhang of pre-miRNA, Sus scrofa" xref: Reactome:REACT_87164 "Exportin-5 recognizes 3' overhang of pre-miRNA, Schizosaccharomyces pombe" xref: Reactome:REACT_89329 "Exportin-5 recognizes 3' overhang of pre-miRNA, Rattus norvegicus" xref: Reactome:REACT_90531 "Exportin-5 recognizes 3' overhang of pre-miRNA, Danio rerio" xref: Reactome:REACT_98683 "Exportin-5 recognizes 3' overhang of pre-miRNA, Taeniopygia guttata" is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003729 name: mRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast is_a: GO:0003723 ! RNA binding [Term] id: GO:0003735 name: structural constituent of ribosome namespace: molecular_function alt_id: GO:0003736 alt_id: GO:0003737 alt_id: GO:0003738 alt_id: GO:0003739 alt_id: GO:0003740 alt_id: GO:0003741 alt_id: GO:0003742 def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0003823 name: antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544] subset: goslim_chembl subset: goslim_pir synonym: "antibody" RELATED [] synonym: "B cell receptor activity" RELATED [] synonym: "immunoglobulin" RELATED [] synonym: "opsonin activity" RELATED [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0003847 name: 1-alkyl-2-acetylglycerophosphocholine esterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] subset: goslim_chembl synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] xref: EC:3.1.1.47 xref: MetaCyc:3.1.1.47-RXN xref: RHEA:17777 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0003848 name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11412] subset: goslim_chembl synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3] synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "HPPK" RELATED [EC:2.7.6.3] synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3] xref: EC:2.7.6.3 xref: KEGG:R03503 xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN xref: RHEA:11412 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0003924 name: GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: Reactome:REACT_100432 "trans-Golgi Network Vesicle Scission, Mus musculus" xref: Reactome:REACT_100708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_101121 "trans-Golgi Network Vesicle Scission, Rattus norvegicus" xref: Reactome:REACT_101520 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_101563 "Loss of Sar1b GTPase, Arabidopsis thaliana" xref: Reactome:REACT_101678 "G-protein alpha subunit is inactivated, Gallus gallus" xref: Reactome:REACT_102040 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis" xref: Reactome:REACT_102208 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Danio rerio" xref: Reactome:REACT_102307 "Adenylate cyclase increases the GTPase activity of Gi alpha, Gallus gallus" xref: Reactome:REACT_102371 "Vesicle Uncoating, Oryza sativa" xref: Reactome:REACT_102510 "trans-Golgi Network Vesicle Scission, Bos taurus" xref: Reactome:REACT_102532 "Loss of Sar1b GTPase, Danio rerio" xref: Reactome:REACT_103518 "trans-Golgi Network Lysosomal Vesicle Scission, Sus scrofa" xref: Reactome:REACT_104081 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_104477 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_104739 "Loss of Sar1b GTPase, Dictyostelium discoideum" xref: Reactome:REACT_105323 "trans-Golgi Network Vesicle Scission, Canis familiaris" xref: Reactome:REACT_105697 "G-protein alpha subunit is inactivated, Saccharomyces cerevisiae" xref: Reactome:REACT_105708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_105854 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_106121 "Vesicle Uncoating, Saccharomyces cerevisiae" xref: Reactome:REACT_106217 "Hydrolysis of eEF1A:GTP, Dictyostelium discoideum" xref: Reactome:REACT_106301 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Mus musculus" xref: Reactome:REACT_106528 "trans-Golgi Network Lysosomal Vesicle Scission, Canis familiaris" xref: Reactome:REACT_107176 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_107306 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_107730 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_107820 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Canis familiaris" xref: Reactome:REACT_108363 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_108653 "G-protein alpha subunit is inactivated, Bos taurus" xref: Reactome:REACT_108825 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Drosophila melanogaster" xref: Reactome:REACT_108837 "trans-Golgi Network Vesicle Scission, Xenopus tropicalis" xref: Reactome:REACT_109360 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_109897 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Danio rerio" xref: Reactome:REACT_110131 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_110443 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_110557 "trans-Golgi Network Vesicle Scission, Danio rerio" xref: Reactome:REACT_110859 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_110879 "G-protein alpha subunit is inactivated, Canis familiaris" xref: Reactome:REACT_110931 "G-protein alpha subunit is inactivated, Sus scrofa" xref: Reactome:REACT_111994 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_112104 "Endocytosis (internalization) of clathrin-coated vesicle, Sus scrofa" xref: Reactome:REACT_112254 "Endocytosis (internalization) of clathrin-coated vesicle, Xenopus tropicalis" xref: Reactome:REACT_112389 "Disassembly of COPII coated vesicle, Gallus gallus" xref: Reactome:REACT_112587 "trans-Golgi Network Vesicle Scission, Schizosaccharomyces pombe" xref: Reactome:REACT_112651 "Vesicle Uncoating, Xenopus tropicalis" xref: Reactome:REACT_112671 "Vesicle Uncoating, Plasmodium falciparum" xref: Reactome:REACT_113058 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_113209 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_113727 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_113832 "Formation of clathrin coated vesicle, Bos taurus" xref: Reactome:REACT_113952 "Formation of clathrin coated vesicle, Schizosaccharomyces pombe" xref: Reactome:REACT_113954 "Endocytosis (internalization) of clathrin-coated vesicle, Schizosaccharomyces pombe" xref: Reactome:REACT_114148 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_114153 "Loss of Sar1b GTPase, Xenopus tropicalis" xref: Reactome:REACT_114188 "Formation of clathrin coated vesicle, Sus scrofa" xref: Reactome:REACT_114210 "G-protein alpha subunit is inactivated, Schizosaccharomyces pombe" xref: Reactome:REACT_114331 "trans-Golgi Network Vesicle Scission, Taeniopygia guttata" xref: Reactome:REACT_114379 "Formation of clathrin coated vesicle, Taeniopygia guttata" xref: Reactome:REACT_114384 "Hydrolysis of eEF1A:GTP, Gallus gallus" xref: Reactome:REACT_114532 "Formation of clathrin coated vesicle, Xenopus tropicalis" xref: Reactome:REACT_114620 "Endocytosis (internalization) of clathrin-coated vesicle, Taeniopygia guttata" xref: Reactome:REACT_114824 "trans-Golgi Network Lysosomal Vesicle Scission, Taeniopygia guttata" xref: Reactome:REACT_115229 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_115324 "Endocytosis (internalization) of clathrin-coated vesicle, Bos taurus" xref: Reactome:REACT_12396 "Loss of Sar1b GTPase, Homo sapiens" xref: Reactome:REACT_12397 "Endocytosis (internalization) of clathrin-coated vesicle, Homo sapiens" xref: Reactome:REACT_12456 "Vesicle Uncoating, Homo sapiens" xref: Reactome:REACT_12612 "Endocytosis of clathrin-coated vesicle, Rattus norvegicus" xref: Reactome:REACT_15316 "G-protein alpha subunit is inactivated, Homo sapiens" xref: Reactome:REACT_15335 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Homo sapiens" xref: Reactome:REACT_15449 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Homo sapiens" xref: Reactome:REACT_15495 "Adenylate cyclase increases the GTPase activity of Gi alpha, Homo sapiens" xref: Reactome:REACT_19123 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19178 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19186 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19194 "trans-Golgi Network Lysosomal Vesicle Scission, Homo sapiens" xref: Reactome:REACT_19219 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19255 "trans-Golgi Network Vesicle Scission, Homo sapiens" xref: Reactome:REACT_19317 "G alpha (i)1 auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_22359 "Formation of clathrin coated vesicle, Homo sapiens" xref: Reactome:REACT_28065 "Vesicle Uncoating, Sus scrofa" xref: Reactome:REACT_28251 "Hydrolysis of eEF1A:GTP, Danio rerio" xref: Reactome:REACT_28269 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Gallus gallus" xref: Reactome:REACT_29162 "trans-Golgi Network Lysosomal Vesicle Scission, Mus musculus" xref: Reactome:REACT_30456 "Hydrolysis of eEF1A:GTP, Plasmodium falciparum" xref: Reactome:REACT_30463 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Bos taurus" xref: Reactome:REACT_30562 "Endocytosis (internalization) of clathrin-coated vesicle, Caenorhabditis elegans" xref: Reactome:REACT_30687 "G-protein alpha subunit is inactivated, Xenopus tropicalis" xref: Reactome:REACT_30707 "trans-Golgi Network Vesicle Scission, Caenorhabditis elegans" xref: Reactome:REACT_30942 "Vesicle Uncoating, Rattus norvegicus" xref: Reactome:REACT_31226 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_31474 "Formation of clathrin coated vesicle, Danio rerio" xref: Reactome:REACT_31530 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Caenorhabditis elegans" xref: Reactome:REACT_31599 "trans-Golgi Network Lysosomal Vesicle Scission, Danio rerio" xref: Reactome:REACT_31709 "Hydrolysis of eEF1A:GTP, Drosophila melanogaster" xref: Reactome:REACT_31727 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata" xref: Reactome:REACT_31850 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_32006 "Loss of Sar1b GTPase, Canis familiaris" xref: Reactome:REACT_32028 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_32914 "Vesicle Uncoating, Dictyostelium discoideum" xref: Reactome:REACT_33948 "trans-Golgi Network Lysosomal Vesicle Scission, Rattus norvegicus" xref: Reactome:REACT_34113 "Vesicle Uncoating, Schizosaccharomyces pombe" xref: Reactome:REACT_34480 "G-protein alpha subunit is inactivated, Caenorhabditis elegans" xref: Reactome:REACT_34592 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_34735 "Adenylate cyclase increases the GTPase activity of Gi alpha, Taeniopygia guttata" xref: Reactome:REACT_348 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_36834 "trans-Golgi Network Lysosomal Vesicle Scission, Bos taurus" xref: Reactome:REACT_37542 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_552 "Hydrolysis of eEF1A:GTP, Homo sapiens" xref: Reactome:REACT_6171 "Hydrolysis of Ran:GTP to Ran:GDP, Homo sapiens" xref: Reactome:REACT_712 "Hydrolysis of reEF1A:GTP, Oryctolagus cuniculus" xref: Reactome:REACT_75799 "Disassembly of COPII coated vesicle, Homo sapiens" xref: Reactome:REACT_77032 "Hydrolysis of eEF1A:GTP, Canis familiaris" xref: Reactome:REACT_77303 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_78069 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_78231 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_78653 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Bos taurus" xref: Reactome:REACT_78945 "G-protein alpha subunit is inactivated, Rattus norvegicus" xref: Reactome:REACT_79558 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_79620 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Mus musculus" xref: Reactome:REACT_80275 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_80612 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_81304 "Loss of Sar1b GTPase, Taeniopygia guttata" xref: Reactome:REACT_81448 "Endocytosis (internalization) of clathrin-coated vesicle, Canis familiaris" xref: Reactome:REACT_81580 "Disassembly of COPII coated vesicle, Mus musculus" xref: Reactome:REACT_81664 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_81879 "Vesicle Uncoating, Drosophila melanogaster" xref: Reactome:REACT_82203 "Formation of clathrin coated vesicle, Canis familiaris" xref: Reactome:REACT_82263 "G-protein alpha subunit is inactivated, Taeniopygia guttata" xref: Reactome:REACT_82457 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_82603 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_82704 "Loss of Sar1b GTPase, Rattus norvegicus" xref: Reactome:REACT_83308 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus" xref: Reactome:REACT_83403 "G-protein alpha subunit is inactivated, Drosophila melanogaster" xref: Reactome:REACT_83440 "Hydrolysis of eEF1A:GTP, Schizosaccharomyces pombe" xref: Reactome:REACT_83730 "Loss of Sar1b GTPase, Plasmodium falciparum" xref: Reactome:REACT_84204 "Endocytosis (internalization) of clathrin-coated vesicle, Danio rerio" xref: Reactome:REACT_84553 "Vesicle Uncoating, Canis familiaris" xref: Reactome:REACT_84696 "G-protein alpha subunit is inactivated, Danio rerio" xref: Reactome:REACT_84712 "Hydrolysis of eEF1A:GTP, Saccharomyces cerevisiae" xref: Reactome:REACT_84735 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_85008 "Vesicle Uncoating, Danio rerio" xref: Reactome:REACT_85418 "Loss of Sar1b GTPase, Gallus gallus" xref: Reactome:REACT_85769 "Disassembly of COPII coated vesicle, Danio rerio" xref: Reactome:REACT_85972 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Canis familiaris" xref: Reactome:REACT_86227 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_86358 "trans-Golgi Network Lysosomal Vesicle Scission, Caenorhabditis elegans" xref: Reactome:REACT_86400 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_86630 "Vesicle Uncoating, Mus musculus" xref: Reactome:REACT_86760 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Gallus gallus" xref: Reactome:REACT_86972 "Loss of Sar1b GTPase, Mus musculus" xref: Reactome:REACT_87409 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_87506 "Formation of clathrin coated vesicle, Rattus norvegicus" xref: Reactome:REACT_87558 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_87653 "Endocytosis (internalization) of clathrin-coated vesicle, Mus musculus" xref: Reactome:REACT_87661 "Formation of clathrin coated vesicle, Drosophila melanogaster" xref: Reactome:REACT_88045 "Vesicle Uncoating, Gallus gallus" xref: Reactome:REACT_88357 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_89231 "Loss of Sar1b GTPase, Bos taurus" xref: Reactome:REACT_89292 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_89416 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_89668 "trans-Golgi Network Lysosomal Vesicle Scission, Xenopus tropicalis" xref: Reactome:REACT_89763 "Vesicle Uncoating, Taeniopygia guttata" xref: Reactome:REACT_90050 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_90064 "Hydrolysis of eEF1A:GTP, Mus musculus" xref: Reactome:REACT_90517 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_90703 "G-protein alpha subunit is inactivated, Dictyostelium discoideum" xref: Reactome:REACT_91199 "Adenylate cyclase increases the GTPase activity of Gi alpha, Bos taurus" xref: Reactome:REACT_91588 "trans-Golgi Network Vesicle Scission, Drosophila melanogaster" xref: Reactome:REACT_92176 "Endocytosis (internalization) of clathrin-coated vesicle, Drosophila melanogaster" xref: Reactome:REACT_92197 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_92198 "Loss of Sar1b GTPase, Oryza sativa" xref: Reactome:REACT_92450 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_93249 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_93305 "Loss of Sar1b GTPase, Sus scrofa" xref: Reactome:REACT_93641 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_93742 "G-protein alpha subunit is inactivated, Mus musculus" xref: Reactome:REACT_93772 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_94019 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_94095 "trans-Golgi Network Vesicle Scission, Sus scrofa" xref: Reactome:REACT_94305 "Adenylate cyclase increases the GTPase activity of Gi alpha, Xenopus tropicalis" xref: Reactome:REACT_94760 "Adenylate cyclase increases the GTPase activity of Gi alpha, Danio rerio" xref: Reactome:REACT_95238 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus" xref: Reactome:REACT_95563 "Adenylate cyclase increases the GTPase activity of Gi alpha, Canis familiaris" xref: Reactome:REACT_96019 "Loss of Sar1b GTPase, Drosophila melanogaster" xref: Reactome:REACT_96132 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_96223 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_96612 "Adenylate cyclase increases the GTPase activity of Gi alpha, Rattus norvegicus" xref: Reactome:REACT_96881 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis" xref: Reactome:REACT_97284 "Loss of Sar1b GTPase, Saccharomyces cerevisiae" xref: Reactome:REACT_97405 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata" xref: Reactome:REACT_97595 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_97794 "Loss of Sar1b GTPase, Schizosaccharomyces pombe" xref: Reactome:REACT_98431 "Formation of clathrin coated vesicle, Caenorhabditis elegans" xref: Reactome:REACT_98556 "Vesicle Uncoating, Bos taurus" xref: Reactome:REACT_98837 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_98859 "Adenylate cyclase increases the GTPase activity of Gi alpha, Mus musculus" xref: Reactome:REACT_99479 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_99533 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_99616 "Formation of clathrin coated vesicle, Mus musculus" xref: RHEA:19669 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003990 name: acetylcholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] subset: goslim_chembl synonym: "AcCholE" RELATED [EC:3.1.1.7] synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7] synonym: "choline esterase I activity" EXACT [EC:3.1.1.7] synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7] xref: EC:3.1.1.7 xref: MetaCyc:ACETYLCHOLINESTERASE-RXN xref: Reactome:REACT_109174 "AcCho is hydrolysed to Cho and acetate by ACHE, Canis familiaris" xref: Reactome:REACT_14816 "AcCho is hydrolysed to Cho and acetate by ACHE, Homo sapiens" xref: Reactome:REACT_85985 "AcCho is hydrolysed to Cho and acetate by ACHE, Mus musculus" xref: Reactome:REACT_89645 "AcCho is hydrolysed to Cho and acetate by ACHE, Danio rerio" xref: Reactome:REACT_96859 "AcCho is hydrolysed to Cho and acetate by ACHE, Xenopus tropicalis" xref: Reactome:REACT_99846 "AcCho is hydrolysed to Cho and acetate by ACHE, Bos taurus" xref: RHEA:17561 is_a: GO:0004104 ! cholinesterase activity [Term] id: GO:0004013 name: adenosylhomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] subset: goslim_chembl synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1] synonym: "SAHase activity" EXACT [EC:3.3.1.1] xref: EC:3.3.1.1 xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN xref: Reactome:REACT_100355 "S-adenoylhomocysteine is hydrolyzed, Bos taurus" xref: Reactome:REACT_100496 "S-adenoylhomocysteine is hydrolyzed, Rattus norvegicus" xref: Reactome:REACT_102024 "S-adenoylhomocysteine is hydrolyzed, Drosophila melanogaster" xref: Reactome:REACT_107160 "S-adenoylhomocysteine is hydrolyzed, Canis familiaris" xref: Reactome:REACT_109196 "S-adenoylhomocysteine is hydrolyzed, Mus musculus" xref: Reactome:REACT_109745 "S-adenoylhomocysteine is hydrolyzed, Oryza sativa" xref: Reactome:REACT_110610 "S-adenoylhomocysteine is hydrolyzed, Caenorhabditis elegans" xref: Reactome:REACT_28097 "S-adenoylhomocysteine is hydrolyzed, Mycobacterium tuberculosis" xref: Reactome:REACT_30892 "S-adenoylhomocysteine is hydrolyzed, Dictyostelium discoideum" xref: Reactome:REACT_31016 "S-adenoylhomocysteine is hydrolyzed, Gallus gallus" xref: Reactome:REACT_6756 "S-adenoylhomocysteine is hydrolyzed, Homo sapiens" xref: Reactome:REACT_77798 "S-adenoylhomocysteine is hydrolyzed, Danio rerio" xref: Reactome:REACT_77951 "S-adenoylhomocysteine is hydrolyzed, Saccharomyces cerevisiae" xref: Reactome:REACT_80809 "S-adenoylhomocysteine is hydrolyzed, Xenopus tropicalis" xref: Reactome:REACT_88005 "S-adenoylhomocysteine is hydrolyzed, Arabidopsis thaliana" xref: Reactome:REACT_95489 "S-adenoylhomocysteine is hydrolyzed, Taeniopygia guttata" xref: Reactome:REACT_99437 "S-adenoylhomocysteine is hydrolyzed, Schizosaccharomyces pombe" xref: RHEA:21708 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0004027 name: alcohol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "alcohol sulphotransferase activity" EXACT [] synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] synonym: "HST" RELATED [EC:2.8.2.2] synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2] xref: EC:2.8.2.2 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: Reactome:REACT_101584 "cholesterol + PAPS => cholesterol sulfate + PAP, Canis familiaris" xref: Reactome:REACT_34593 "cholesterol + PAPS => cholesterol sulfate + PAP, Gallus gallus" xref: Reactome:REACT_59193 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Canis familiaris" xref: Reactome:REACT_6881 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6957 "cholesterol + PAPS => cholesterol sulfate + PAP, Homo sapiens" xref: Reactome:REACT_79006 "cholesterol + PAPS => cholesterol sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_80452 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Mus musculus" xref: Reactome:REACT_94728 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Gallus gallus" xref: Reactome:REACT_95422 "cholesterol + PAPS => cholesterol sulfate + PAP, Mus musculus" xref: Reactome:REACT_96417 "27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP, Rattus norvegicus" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004062 name: aryl sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] subset: goslim_chembl synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "aryl sulphotransferase activity" EXACT [] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "PST" RELATED [EC:2.8.2.1] synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] xref: EC:2.8.2.1 xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN xref: Reactome:REACT_101593 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Drosophila melanogaster" xref: Reactome:REACT_101626 "Acetaminophen can form an O- sulfate conjugate, Xenopus tropicalis" xref: Reactome:REACT_103168 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Bos taurus" xref: Reactome:REACT_103360 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Danio rerio" xref: Reactome:REACT_103392 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Gallus gallus" xref: Reactome:REACT_103811 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_104618 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Bos taurus" xref: Reactome:REACT_105302 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Xenopus tropicalis" xref: Reactome:REACT_105483 "Phenol can form a sulfate conjugate, Mus musculus" xref: Reactome:REACT_106988 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Bos taurus" xref: Reactome:REACT_107852 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Gallus gallus" xref: Reactome:REACT_109219 "Phenol can form a sulfate conjugate, Canis familiaris" xref: Reactome:REACT_112861 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_113420 "Dopamine can form an O-sulfate conjugate, Danio rerio" xref: Reactome:REACT_113755 "Acetaminophen can form an O- sulfate conjugate, Rattus norvegicus" xref: Reactome:REACT_113826 "Acetaminophen can form an O- sulfate conjugate, Danio rerio" xref: Reactome:REACT_114350 "Phenol can form a sulfate conjugate, Rattus norvegicus" xref: Reactome:REACT_114511 "Phenol can form a sulfate conjugate, Danio rerio" xref: Reactome:REACT_114894 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Danio rerio" xref: Reactome:REACT_115246 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Rattus norvegicus" xref: Reactome:REACT_115272 "Dopamine can form an O-sulfate conjugate, Rattus norvegicus" xref: Reactome:REACT_28338 "Acetaminophen can form an O- sulfate conjugate, Canis familiaris" xref: Reactome:REACT_28779 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Mus musculus" xref: Reactome:REACT_30659 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_31265 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Canis familiaris" xref: Reactome:REACT_31366 "Phenol can form a sulfate conjugate, Xenopus tropicalis" xref: Reactome:REACT_32021 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Bos taurus" xref: Reactome:REACT_32963 "Dopamine can form an O-sulfate conjugate, Canis familiaris" xref: Reactome:REACT_33894 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_34807 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Danio rerio" xref: Reactome:REACT_6722 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6740 "Dopamine can form an O-sulfate conjugate, Homo sapiens" xref: Reactome:REACT_6765 "Acetaminophen can form an O- sulfate conjugate, Homo sapiens" xref: Reactome:REACT_6855 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6868 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Homo sapiens" xref: Reactome:REACT_6897 "Phenol can form a sulfate conjugate, Homo sapiens" xref: Reactome:REACT_6961 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Homo sapiens" xref: Reactome:REACT_77729 "Dopamine can form an O-sulfate conjugate, Xenopus tropicalis" xref: Reactome:REACT_78668 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Canis familiaris" xref: Reactome:REACT_80310 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Canis familiaris" xref: Reactome:REACT_80654 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Mus musculus" xref: Reactome:REACT_80880 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Sus scrofa" xref: Reactome:REACT_81976 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_83825 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Mus musculus" xref: Reactome:REACT_83936 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_84713 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_87537 "Acetaminophen can form an O- sulfate conjugate, Bos taurus" xref: Reactome:REACT_88863 "N-hydroxy-4-aminobiphenyl can form a sulfate conjugate, Mus musculus" xref: Reactome:REACT_89258 "Dopamine can form an O-sulfate conjugate, Mus musculus" xref: Reactome:REACT_89426 "Dopamine can form an O-sulfate conjugate, Bos taurus" xref: Reactome:REACT_90170 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_90269 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Danio rerio" xref: Reactome:REACT_90981 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP, Gallus gallus" xref: Reactome:REACT_91386 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Sus scrofa" xref: Reactome:REACT_91525 "Acetaminophen can form an O- sulfate conjugate, Mus musculus" xref: Reactome:REACT_91946 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_92808 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP, Canis familiaris" xref: Reactome:REACT_94928 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP, Drosophila melanogaster" xref: Reactome:REACT_95232 "Phenol can form a sulfate conjugate, Bos taurus" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004104 name: cholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] subset: goslim_chembl synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8] synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8] synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "BtChoEase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8] synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8] synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8] xref: EC:3.1.1.8 xref: MetaCyc:CHOLINESTERASE-RXN xref: RHEA:21964 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0004170 name: dUTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] subset: goslim_chembl synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP pyrophosphatase activity" EXACT [] synonym: "dUTPase activity" EXACT [EC:3.6.1.23] xref: EC:3.6.1.23 xref: KEGG:R02100 xref: MetaCyc:DUTP-PYROP-RXN xref: Reactome:REACT_103311 "dUTP + H2O => dUMP + pyrophosphate, Saccharomyces cerevisiae" xref: Reactome:REACT_106534 "dUTP + H2O => dUMP + pyrophosphate, Drosophila melanogaster" xref: Reactome:REACT_108277 "dUTP + H2O => dUMP + pyrophosphate, Canis familiaris" xref: Reactome:REACT_108948 "dUTP + H2O => dUMP + pyrophosphate, Rattus norvegicus" xref: Reactome:REACT_109343 "dUTP + H2O => dUMP + pyrophosphate, Gallus gallus" xref: Reactome:REACT_150 "dUTP + H2O => dUMP + pyrophosphate, Homo sapiens" xref: Reactome:REACT_30531 "dUTP + H2O => dUMP + pyrophosphate, Mycobacterium tuberculosis" xref: Reactome:REACT_54215 "dUTP + H2O => dUMP + pyrophosphate, Bos taurus" xref: Reactome:REACT_76954 "dUTP + H2O => dUMP + pyrophosphate, Dictyostelium discoideum" xref: Reactome:REACT_77124 "dUTP + H2O => dUMP + pyrophosphate, Danio rerio" xref: Reactome:REACT_81301 "dUTP + H2O => dUMP + pyrophosphate, Arabidopsis thaliana" xref: Reactome:REACT_82609 "dUTP + H2O => dUMP + pyrophosphate, Mus musculus" xref: Reactome:REACT_87407 "dUTP + H2O => dUMP + pyrophosphate, Escherichia coli" xref: Reactome:REACT_92173 "dUTP + H2O => dUMP + pyrophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_92619 "dUTP + H2O => dUMP + pyrophosphate, Caenorhabditis elegans" xref: Reactome:REACT_96660 "dUTP + H2O => dUMP + pyrophosphate, Oryza sativa" xref: Reactome:REACT_96711 "dUTP + H2O => dUMP + pyrophosphate, Plasmodium falciparum" xref: Reactome:REACT_97265 "dUTP + H2O => dUMP + pyrophosphate, Taeniopygia guttata" xref: RHEA:10248 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0004252 name: serine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] subset: goslim_chembl synonym: "blood coagulation factor activity" RELATED [] synonym: "serine elastase activity" RELATED [GOC:krc] xref: EC:3.4.21 xref: Reactome:REACT_100031 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Danio rerio" xref: Reactome:REACT_100125 "Granzyme-B activates BID by cleavage, Mus musculus" xref: Reactome:REACT_100194 "Thrombin-mediated activation of Proteinase-activated receptors, Taeniopygia guttata" xref: Reactome:REACT_100271 "pro-factor IX -> factor IX + factor IX propeptide, Rattus norvegicus" xref: Reactome:REACT_100321 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Rattus norvegicus" xref: Reactome:REACT_10058 "Part of pro-beta-NGF is processed to mature beta-NGF, Homo sapiens" xref: Reactome:REACT_100669 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Rattus norvegicus" xref: Reactome:REACT_100764 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Gallus gallus" xref: Reactome:REACT_100842 "pro-factor VII -> factor VII + factor VII propeptide, Canis familiaris" xref: Reactome:REACT_100919 "Formation of alternate C5 convertase, Mus musculus" xref: Reactome:REACT_100938 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Canis familiaris" xref: Reactome:REACT_101008 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Rattus norvegicus" xref: Reactome:REACT_101012 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Danio rerio" xref: Reactome:REACT_101033 "Processing of Proglucagon to Glucagon-like Peptide-1, Rattus norvegicus" xref: Reactome:REACT_101265 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Gallus gallus" xref: Reactome:REACT_101293 "pro-factor IX -> factor IX + factor IX propeptide, Mus musculus" xref: Reactome:REACT_101358 "Notch 1 precursor cleaved to form a heterodimer, Rattus norvegicus" xref: Reactome:REACT_101408 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Bos taurus" xref: Reactome:REACT_101486 "Granzyme-B activates BID by cleavage, Canis familiaris" xref: Reactome:REACT_101710 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Bos taurus" xref: Reactome:REACT_102047 "Processing of preproGLP-1 to proGLP-1, Xenopus tropicalis" xref: Reactome:REACT_102222 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Danio rerio" xref: Reactome:REACT_102226 "factor Va -> factor Vi, Taeniopygia guttata" xref: Reactome:REACT_102247 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Sus scrofa" xref: Reactome:REACT_102300 "pro-factor VII -> factor VII + factor VII propeptide, Gallus gallus" xref: Reactome:REACT_102318 "Processing of preproGLP-1 to proGLP-1, Mus musculus" xref: Reactome:REACT_102435 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Canis familiaris" xref: Reactome:REACT_102450 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Bos taurus" xref: Reactome:REACT_102555 "Cleavage of ATF6-alpha by S1P, Drosophila melanogaster" xref: Reactome:REACT_102564 "Notch 1 precursor cleaved to form a heterodimer, Mus musculus" xref: Reactome:REACT_102660 "Factor D cleaves C3b-bound Factor B, Danio rerio" xref: Reactome:REACT_102717 "factor Va -> factor Vi, Bos taurus" xref: Reactome:REACT_102762 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Mus musculus" xref: Reactome:REACT_103193 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Taeniopygia guttata" xref: Reactome:REACT_103297 "Extracellular processing of novel PDGFs, Gallus gallus" xref: Reactome:REACT_103317 "protein C -> activated protein C + protein C heavy chain activation peptide, Bos taurus" xref: Reactome:REACT_103386 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Xenopus tropicalis" xref: Reactome:REACT_103434 "Processing of Proinsulin to Insulin, Rattus norvegicus" xref: Reactome:REACT_103529 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Canis familiaris" xref: Reactome:REACT_103532 "Processing of classical PDGFs, Gallus gallus" xref: Reactome:REACT_103534 "Latent TGF-beta1 is cleaved by furin, Xenopus tropicalis" xref: Reactome:REACT_103821 "pro-factor X -> factor X + factor X propeptide, Gallus gallus" xref: Reactome:REACT_104063 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Sus scrofa" xref: Reactome:REACT_104096 "Processing of preproGLP-1 to proGLP-1, Canis familiaris" xref: Reactome:REACT_104436 "pro-factor IX -> factor IX + factor IX propeptide, Gallus gallus" xref: Reactome:REACT_104461 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Danio rerio" xref: Reactome:REACT_104513 "Conversion of C2 into C2a and C2b, Mus musculus" xref: Reactome:REACT_104582 "Part of pro-beta-NGF is processed to mature beta-NGF, Sus scrofa" xref: Reactome:REACT_104633 "factor Va -> factor Vi, Mus musculus" xref: Reactome:REACT_104789 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Taeniopygia guttata" xref: Reactome:REACT_104808 "Processing of Proinsulin to Insulin, Taeniopygia guttata" xref: Reactome:REACT_104872 "Cleavage of ATF6-alpha by S1P, Gallus gallus" xref: Reactome:REACT_104930 "pro-factor IX -> factor IX + factor IX propeptide, Sus scrofa" xref: Reactome:REACT_105381 "Notch 1 precursor cleaved to form a heterodimer, Danio rerio" xref: Reactome:REACT_105667 "Processing of Proglucagon to Glucagon-like Peptide-1, Canis familiaris" xref: Reactome:REACT_105786 "Processing of Proglucagon to Glucagon-like Peptide-1, Taeniopygia guttata" xref: Reactome:REACT_106150 "pro-GAS6 -> GAS6 + GAS6 propeptide, Sus scrofa" xref: Reactome:REACT_106201 "Processing of proGIP to GIP, Rattus norvegicus" xref: Reactome:REACT_106288 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Rattus norvegicus" xref: Reactome:REACT_106360 "pro-factor IX -> factor IX + factor IX propeptide, Danio rerio" xref: Reactome:REACT_106442 "Cleavage of the Signal Peptide of Preproghrelin, Bos taurus" xref: Reactome:REACT_1065 "pro-prothrombin -> prothrombin + prothrombin propeptide, Homo sapiens" xref: Reactome:REACT_106545 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Canis familiaris" xref: Reactome:REACT_106587 "pro-prothrombin -> prothrombin + prothrombin propeptide, Mus musculus" xref: Reactome:REACT_106621 "Notch 3 precursor cleaved to form a heterodimer, Canis familiaris" xref: Reactome:REACT_106696 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Canis familiaris" xref: Reactome:REACT_106726 "pro-GAS6 -> GAS6 + GAS6 propeptide, Taeniopygia guttata" xref: Reactome:REACT_106877 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Danio rerio" xref: Reactome:REACT_106997 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Rattus norvegicus" xref: Reactome:REACT_107059 "pro-factor IX -> factor IX + factor IX propeptide, Canis familiaris" xref: Reactome:REACT_1071 "factor Va -> factor Vi, Homo sapiens" xref: Reactome:REACT_107173 "pro-protein Z -> protein Z + protein Z propeptide, Rattus norvegicus" xref: Reactome:REACT_107386 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Sus scrofa" xref: Reactome:REACT_107456 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Sus scrofa" xref: Reactome:REACT_107494 "Processing of preproGLP-1 to proGLP-1, Sus scrofa" xref: Reactome:REACT_107597 "Granzyme-B activates BID by cleavage, Sus scrofa" xref: Reactome:REACT_107831 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Gallus gallus" xref: Reactome:REACT_107946 "pro-protein S -> protein S + protein S propeptide, Sus scrofa" xref: Reactome:REACT_108231 "Activation of C1R, Sus scrofa" xref: Reactome:REACT_108261 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Bos taurus" xref: Reactome:REACT_108266 "Cleavage of ATF6-alpha by S1P, Canis familiaris" xref: Reactome:REACT_108267 "Processing of proGIP to GIP, Canis familiaris" xref: Reactome:REACT_108525 "pro-factor VII -> factor VII + factor VII propeptide, Danio rerio" xref: Reactome:REACT_108824 "Extracellular processing of novel PDGFs, Canis familiaris" xref: Reactome:REACT_108968 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Mus musculus" xref: Reactome:REACT_109057 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Danio rerio" xref: Reactome:REACT_109058 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Canis familiaris" xref: Reactome:REACT_109495 "Notch 2 precursor cleaved to form a heterodimer, Drosophila melanogaster" xref: Reactome:REACT_109499 "Processing of Proglucagon to Glucagon-like Peptide-1, Sus scrofa" xref: Reactome:REACT_1097 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Homo sapiens" xref: Reactome:REACT_109879 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Canis familiaris" xref: Reactome:REACT_109955 "Cleavage of ATF6-alpha by S1P, Taeniopygia guttata" xref: Reactome:REACT_110020 "Thrombin-mediated activation of Proteinase-activated receptors, Mus musculus" xref: Reactome:REACT_110040 "pro-factor IX -> factor IX + factor IX propeptide, Taeniopygia guttata" xref: Reactome:REACT_110135 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Gallus gallus" xref: Reactome:REACT_110160 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Taeniopygia guttata" xref: Reactome:REACT_110219 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Mus musculus" xref: Reactome:REACT_110269 "factor VII -> factor VIIa, Danio rerio" xref: Reactome:REACT_110434 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Mus musculus" xref: Reactome:REACT_110438 "Part of pro-beta-NGF is processed to mature beta-NGF, Mus musculus" xref: Reactome:REACT_110522 "Notch 4 precursor cleaved to form a heterodimer, Bos taurus" xref: Reactome:REACT_110563 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Danio rerio" xref: Reactome:REACT_110705 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Taeniopygia guttata" xref: Reactome:REACT_110746 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Mus musculus" xref: Reactome:REACT_110798 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Bos taurus" xref: Reactome:REACT_110898 "Extracellular processing of novel PDGFs, Mus musculus" xref: Reactome:REACT_111180 "Cleavage of Nodal Proprotein, Mus musculus" xref: Reactome:REACT_111228 "Cleavage of NODAL Proprotein, Homo sapiens" xref: Reactome:REACT_1117 "pro-GAS6 -> GAS6 + GAS6 propeptide, Homo sapiens" xref: Reactome:REACT_112053 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Canis familiaris" xref: Reactome:REACT_112058 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Xenopus tropicalis" xref: Reactome:REACT_112131 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Gallus gallus" xref: Reactome:REACT_11214 "The signal peptide is excised from pre-pro-NGF, Mus musculus" xref: Reactome:REACT_112143 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Bos taurus" xref: Reactome:REACT_112184 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Xenopus tropicalis" xref: Reactome:REACT_112194 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Danio rerio" xref: Reactome:REACT_112204 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Sus scrofa" xref: Reactome:REACT_112253 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Danio rerio" xref: Reactome:REACT_112277 "Granzyme-B activates BID by cleavage, Xenopus tropicalis" xref: Reactome:REACT_112440 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Xenopus tropicalis" xref: Reactome:REACT_112453 "Notch 3 precursor cleaved to form a heterodimer, Drosophila melanogaster" xref: Reactome:REACT_112489 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Bos taurus" xref: Reactome:REACT_112510 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Rattus norvegicus" xref: Reactome:REACT_112675 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Xenopus tropicalis" xref: Reactome:REACT_1127 "Notch 1 precursor cleaved to form a heterodimer, Homo sapiens" xref: Reactome:REACT_112763 "Notch 4 precursor cleaved to form a heterodimer, Xenopus tropicalis" xref: Reactome:REACT_112800 "Latent TGF-beta1 is cleaved by furin, Caenorhabditis elegans" xref: Reactome:REACT_112843 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Xenopus tropicalis" xref: Reactome:REACT_113002 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Rattus norvegicus" xref: Reactome:REACT_113239 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Gallus gallus" xref: Reactome:REACT_113539 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Taeniopygia guttata" xref: Reactome:REACT_113596 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Xenopus tropicalis" xref: Reactome:REACT_113760 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Sus scrofa" xref: Reactome:REACT_113831 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Xenopus tropicalis" xref: Reactome:REACT_114057 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Sus scrofa" xref: Reactome:REACT_114147 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Mus musculus" xref: Reactome:REACT_114209 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Canis familiaris" xref: Reactome:REACT_114347 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Xenopus tropicalis" xref: Reactome:REACT_114464 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Xenopus tropicalis" xref: Reactome:REACT_115043 "Latent TGF-beta1 is cleaved by furin, Drosophila melanogaster" xref: Reactome:REACT_115078 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Danio rerio" xref: Reactome:REACT_115086 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Taeniopygia guttata" xref: Reactome:REACT_115256 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Mus musculus" xref: Reactome:REACT_115338 "protein C -> activated protein C + protein C heavy chain activation peptide, Xenopus tropicalis" xref: Reactome:REACT_115742 "Signal peptide cleavage from ribosome-associated nascent protein, Homo sapiens" xref: Reactome:REACT_118086 "Signal peptide cleavage from ribosome-associated nascent protein, Oryza sativa" xref: Reactome:REACT_118100 "Signal peptide cleavage from ribosome-associated nascent protein, Xenopus tropicalis" xref: Reactome:REACT_118128 "Signal peptide cleavage from ribosome-associated nascent protein, Arabidopsis thaliana" xref: Reactome:REACT_118174 "Signal peptide cleavage from ribosome-associated nascent protein, Caenorhabditis elegans" xref: Reactome:REACT_118183 "Signal peptide cleavage from ribosome-associated nascent protein, Danio rerio" xref: Reactome:REACT_118198 "Signal peptide cleavage from ribosome-associated nascent protein, Drosophila melanogaster" xref: Reactome:REACT_118250 "Signal peptide cleavage from ribosome-associated nascent protein, Dictyostelium discoideum" xref: Reactome:REACT_118264 "Signal peptide cleavage from ribosome-associated nascent protein, Taeniopygia guttata" xref: Reactome:REACT_118287 "Signal peptide cleavage from ribosome-associated nascent protein, Gallus gallus" xref: Reactome:REACT_118304 "Signal peptide cleavage from ribosome-associated nascent protein, Canis familiaris" xref: Reactome:REACT_118357 "Signal peptide cleavage from ribosome-associated nascent protein, Plasmodium falciparum" xref: Reactome:REACT_118392 "Signal peptide cleavage from ribosome-associated nascent protein, Mus musculus" xref: Reactome:REACT_118422 "Signal peptide cleavage from ribosome-associated nascent protein, Rattus norvegicus" xref: Reactome:REACT_1243 "Notch 3 precursor cleaved to form a heterodimer, Homo sapiens" xref: Reactome:REACT_1423 "pro-factor VII -> factor VII + factor VII propeptide, Homo sapiens" xref: Reactome:REACT_1446 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Homo sapiens" xref: Reactome:REACT_1455 "factor XII -> factor XIIa, Homo sapiens" xref: Reactome:REACT_1456 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Homo sapiens" xref: Reactome:REACT_1500 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Homo sapiens" xref: Reactome:REACT_15308 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Homo sapiens" xref: Reactome:REACT_1535 "pro-protein Z -> protein Z + protein Z propeptide, Homo sapiens" xref: Reactome:REACT_1536 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Homo sapiens" xref: Reactome:REACT_15373 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Homo sapiens" xref: Reactome:REACT_15374 "Processing of Proinsulin to Insulin, Homo sapiens" xref: Reactome:REACT_15393 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Homo sapiens" xref: Reactome:REACT_15465 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Homo sapiens" xref: Reactome:REACT_158 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Homo sapiens" xref: Reactome:REACT_1581 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Homo sapiens" xref: Reactome:REACT_1610 "Granzyme-B activates BID by cleavage, Homo sapiens" xref: Reactome:REACT_1644 "pro-factor X -> factor X + factor X propeptide, Homo sapiens" xref: Reactome:REACT_1668 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst), Homo sapiens" xref: Reactome:REACT_1676 "Notch 2 precursor cleaved to form a heterodimer, Homo sapiens" xref: Reactome:REACT_16891 "Extracellular processing of novel PDGFs, Homo sapiens" xref: Reactome:REACT_17059 "Processing of classical PDGFs, Homo sapiens" xref: Reactome:REACT_18401 "Cleavage of ATF6-alpha by S1P, Homo sapiens" xref: Reactome:REACT_1860 "pro-protein S -> protein S + protein S propeptide, Homo sapiens" xref: Reactome:REACT_19170 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Homo sapiens" xref: Reactome:REACT_19296 "Cleavage of the Signal Peptide of Preproghrelin, Homo sapiens" xref: Reactome:REACT_2004 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Homo sapiens" xref: Reactome:REACT_2028 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Homo sapiens" xref: Reactome:REACT_20669 "Cleavage of the Signal Peptide of Preprolactin by Signal Peptidase (Canis), Bos taurus" xref: Reactome:REACT_2073 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Homo sapiens" xref: Reactome:REACT_2114 "Notch 4 precursor cleaved to form a heterodimer, Homo sapiens" xref: Reactome:REACT_214 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Homo sapiens" xref: Reactome:REACT_2146 "pro-protein C -> protein C + protein C propeptide, Homo sapiens" xref: Reactome:REACT_217 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer, Homo sapiens" xref: Reactome:REACT_2226 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Homo sapiens" xref: Reactome:REACT_23836 "Processing of ProGip to Gip (mouse), Mus musculus" xref: Reactome:REACT_23854 "Processing of Proglucagon to Glucagon-like Peptide-1 (7-37) (mouse), Mus musculus" xref: Reactome:REACT_23859 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Homo sapiens" xref: Reactome:REACT_23880 "Processing of proGIP to GIP, Homo sapiens" xref: Reactome:REACT_23888 "Processing of preproGIP to proGIP, Homo sapiens" xref: Reactome:REACT_23895 "Processing of Proglucagon to Glucagon-like Peptide-1, Homo sapiens" xref: Reactome:REACT_23907 "Processing of preproGLP-1 to proGLP-1, Homo sapiens" xref: Reactome:REACT_23940 "Processing of Proglucagon to Glucagon-like Peptide-1 (7-36) (mouse), Mus musculus" xref: Reactome:REACT_23981 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Homo sapiens" xref: Reactome:REACT_245 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Homo sapiens" xref: Reactome:REACT_28116 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Mus musculus" xref: Reactome:REACT_28152 "pro-prothrombin -> prothrombin + prothrombin propeptide, Sus scrofa" xref: Reactome:REACT_28164 "Part of pro-beta-NGF is processed to mature beta-NGF, Rattus norvegicus" xref: Reactome:REACT_28332 "Cleavage of ATF6-alpha by S1P, Danio rerio" xref: Reactome:REACT_28354 "Conversion of C4 into C4a and C4b, Bos taurus" xref: Reactome:REACT_28382 "pro-GAS6 -> GAS6 + GAS6 propeptide, Canis familiaris" xref: Reactome:REACT_28391 "pro-protein C -> protein C + protein C propeptide, Taeniopygia guttata" xref: Reactome:REACT_28533 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Canis familiaris" xref: Reactome:REACT_28597 "protein C -> activated protein C + protein C heavy chain activation peptide, Rattus norvegicus" xref: Reactome:REACT_28631 "Processing of classical PDGFs, Xenopus tropicalis" xref: Reactome:REACT_28673 "Notch 2 precursor cleaved to form a heterodimer, Gallus gallus" xref: Reactome:REACT_28723 "protein C -> activated protein C + protein C heavy chain activation peptide, Canis familiaris" xref: Reactome:REACT_28758 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Gallus gallus" xref: Reactome:REACT_28923 "Activation of C1S, Mus musculus" xref: Reactome:REACT_29316 "pro-factor X -> factor X + factor X propeptide, Xenopus tropicalis" xref: Reactome:REACT_29593 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Bos taurus" xref: Reactome:REACT_29596 "Extracellular processing of novel PDGFs, Taeniopygia guttata" xref: Reactome:REACT_29653 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Gallus gallus" xref: Reactome:REACT_29792 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Canis familiaris" xref: Reactome:REACT_29846 "pro-factor X -> factor X + factor X propeptide, Taeniopygia guttata" xref: Reactome:REACT_29855 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Danio rerio" xref: Reactome:REACT_29954 "Activation of C1R, Xenopus tropicalis" xref: Reactome:REACT_30094 "factor V -> factor Va + factor V activation peptide, Taeniopygia guttata" xref: Reactome:REACT_30232 "Cleavage of the Signal Peptide of Preproghrelin, Mus musculus" xref: Reactome:REACT_30422 "Notch 4 precursor cleaved to form a heterodimer, Mus musculus" xref: Reactome:REACT_30489 "Processing of Proinsulin to Insulin, Danio rerio" xref: Reactome:REACT_30505 "Processing of proGIP to GIP, Bos taurus" xref: Reactome:REACT_31158 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Taeniopygia guttata" xref: Reactome:REACT_31164 "pro-protein S -> protein S + protein S propeptide, Mus musculus" xref: Reactome:REACT_31280 "Processing of Proinsulin to Insulin, Xenopus tropicalis" xref: Reactome:REACT_31419 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Sus scrofa" xref: Reactome:REACT_31420 "Part of pro-beta-NGF is processed to mature beta-NGF, Taeniopygia guttata" xref: Reactome:REACT_31582 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Bos taurus" xref: Reactome:REACT_31786 "pro-GAS6 -> GAS6 + GAS6 propeptide, Bos taurus" xref: Reactome:REACT_31846 "pro-protein S -> protein S + protein S propeptide, Danio rerio" xref: Reactome:REACT_32001 "Notch 2 precursor cleaved to form a heterodimer, Canis familiaris" xref: Reactome:REACT_32108 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Canis familiaris" xref: Reactome:REACT_32118 "factor XII -> factor XIIa, Rattus norvegicus" xref: Reactome:REACT_32241 "Processing of preproGLP-1 to proGLP-1, Rattus norvegicus" xref: Reactome:REACT_32341 "Activation of C1R, Bos taurus" xref: Reactome:REACT_32350 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Bos taurus" xref: Reactome:REACT_32753 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Rattus norvegicus" xref: Reactome:REACT_32785 "Processing of classical PDGFs, Sus scrofa" xref: Reactome:REACT_32919 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Danio rerio" xref: Reactome:REACT_32975 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Mus musculus" xref: Reactome:REACT_32977 "Thrombin-mediated activation of Proteinase-activated receptors, Xenopus tropicalis" xref: Reactome:REACT_33012 "Processing of classical PDGFs, Mus musculus" xref: Reactome:REACT_33038 "Activation of C1S, Rattus norvegicus" xref: Reactome:REACT_33127 "Cleavage of C3 by C3 convertases, Sus scrofa" xref: Reactome:REACT_33210 "Latent TGF-beta1 is cleaved by furin, Canis familiaris" xref: Reactome:REACT_33288 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Rattus norvegicus" xref: Reactome:REACT_33326 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Gallus gallus" xref: Reactome:REACT_33367 "Thrombin-mediated activation of Proteinase-activated receptors, Bos taurus" xref: Reactome:REACT_33418 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Canis familiaris" xref: Reactome:REACT_33841 "pro-protein Z -> protein Z + protein Z propeptide, Mus musculus" xref: Reactome:REACT_33939 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Rattus norvegicus" xref: Reactome:REACT_33975 "Extracellular processing of novel PDGFs, Bos taurus" xref: Reactome:REACT_34064 "factor V -> factor Va + factor V activation peptide, Sus scrofa" xref: Reactome:REACT_34085 "factor VII -> factor VIIa, Rattus norvegicus" xref: Reactome:REACT_34137 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Bos taurus" xref: Reactome:REACT_34159 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Mus musculus" xref: Reactome:REACT_34262 "Conversion of C2 into C2a and C2b, Gallus gallus" xref: Reactome:REACT_34275 "Processing of Proinsulin to Insulin, Bos taurus" xref: Reactome:REACT_34474 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Mus musculus" xref: Reactome:REACT_34555 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Danio rerio" xref: Reactome:REACT_34558 "Processing of Proglucagon to Glucagon-like Peptide-1, Gallus gallus" xref: Reactome:REACT_374 "protein C -> activated protein C + protein C heavy chain activation peptide, Homo sapiens" xref: Reactome:REACT_37926 "Processing of preproGLP-1 to proGLP-1, Gallus gallus" xref: Reactome:REACT_41363 "factor VII -> factor VIIa, Canis familiaris" xref: Reactome:REACT_41656 "Thrombin-mediated activation of Proteinase-activated receptors, Canis familiaris" xref: Reactome:REACT_420 "pro-factor IX -> factor IX + factor IX propeptide, Homo sapiens" xref: Reactome:REACT_493 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Homo sapiens" xref: Reactome:REACT_547 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Homo sapiens" xref: Reactome:REACT_598 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Homo sapiens" xref: Reactome:REACT_59890 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Gallus gallus" xref: Reactome:REACT_64320 "factor V -> factor Va + factor V activation peptide, Bos taurus" xref: Reactome:REACT_65367 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Canis familiaris" xref: Reactome:REACT_6931 "Latent TGF-beta1 is cleaved by furin, Homo sapiens" xref: Reactome:REACT_708 "factor V -> factor Va + factor V activation peptide, Homo sapiens" xref: Reactome:REACT_72 "Thrombin-mediated activation of Proteinase-activated receptors, Homo sapiens" xref: Reactome:REACT_729 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin), Homo sapiens" xref: Reactome:REACT_739 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Homo sapiens" xref: Reactome:REACT_75563 "pro-factor X -> factor X + factor X propeptide, Rattus norvegicus" xref: Reactome:REACT_76942 "Processing of Proinsulin to Insulin, Canis familiaris" xref: Reactome:REACT_76945 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Mus musculus" xref: Reactome:REACT_76972 "factor V -> factor Va + factor V activation peptide, Gallus gallus" xref: Reactome:REACT_77116 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Mus musculus" xref: Reactome:REACT_77208 "pro-factor X -> factor X + factor X propeptide, Mus musculus" xref: Reactome:REACT_77419 "factor V -> factor Va + factor V activation peptide, Mus musculus" xref: Reactome:REACT_77528 "Notch 3 precursor cleaved to form a heterodimer, Mus musculus" xref: Reactome:REACT_77756 "pro-protein C -> protein C + protein C propeptide, Xenopus tropicalis" xref: Reactome:REACT_77779 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Gallus gallus" xref: Reactome:REACT_77797 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Taeniopygia guttata" xref: Reactome:REACT_77805 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Bos taurus" xref: Reactome:REACT_77894 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Mus musculus" xref: Reactome:REACT_77968 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Danio rerio" xref: Reactome:REACT_78022 "pro-factor VII -> factor VII + factor VII propeptide, Xenopus tropicalis" xref: Reactome:REACT_78188 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Sus scrofa" xref: Reactome:REACT_78229 "factor Va -> factor Vi, Rattus norvegicus" xref: Reactome:REACT_78374 "pro-protein C -> protein C + protein C propeptide, Rattus norvegicus" xref: Reactome:REACT_78406 "Thrombin-mediated activation of Proteinase-activated receptors, Danio rerio" xref: Reactome:REACT_78477 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Sus scrofa" xref: Reactome:REACT_78734 "Extracellular processing of novel PDGFs, Sus scrofa" xref: Reactome:REACT_78776 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Danio rerio" xref: Reactome:REACT_78830 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Sus scrofa" xref: Reactome:REACT_79061 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Bos taurus" xref: Reactome:REACT_79079 "Latent TGF-beta1 is cleaved by furin, Danio rerio" xref: Reactome:REACT_79192 "Activation of C1S, Sus scrofa" xref: Reactome:REACT_79426 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Sus scrofa" xref: Reactome:REACT_79431 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Gallus gallus" xref: Reactome:REACT_7948 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Homo sapiens" xref: Reactome:REACT_79486 "Cleavage of C3 by C3 convertases, Canis familiaris" xref: Reactome:REACT_79539 "Notch 4 precursor cleaved to form a heterodimer, Canis familiaris" xref: Reactome:REACT_7959 "Conversion of C2 into C2a and C2b, Homo sapiens" xref: Reactome:REACT_79601 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Mus musculus" xref: Reactome:REACT_79616 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Bos taurus" xref: Reactome:REACT_79687 "Processing of classical PDGFs, Bos taurus" xref: Reactome:REACT_7977 "Activation of C1S, Homo sapiens" xref: Reactome:REACT_7978 "Activation of C1R, Homo sapiens" xref: Reactome:REACT_7981 "Factor D cleaves C3(H2O)-bound Factor B, Homo sapiens" xref: Reactome:REACT_79835 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Mus musculus" xref: Reactome:REACT_7986 "Formation of alternate C5 convertase, Homo sapiens" xref: Reactome:REACT_7989 "Activation of C5, Homo sapiens" xref: Reactome:REACT_7990 "Cleavage of C3 by C3 convertases, Homo sapiens" xref: Reactome:REACT_79971 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Gallus gallus" xref: Reactome:REACT_8002 "Conversion of C4 into C4a and C4b, Homo sapiens" xref: Reactome:REACT_80078 "Conversion of C4 into C4a and C4b, Mus musculus" xref: Reactome:REACT_80147 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Danio rerio" xref: Reactome:REACT_8026 "Factor D cleaves C3b-bound Factor B, Homo sapiens" xref: Reactome:REACT_80346 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Mus musculus" xref: Reactome:REACT_80454 "Processing of preproGLP-1 to proGLP-1, Danio rerio" xref: Reactome:REACT_80614 "Processing of classical PDGFs, Danio rerio" xref: Reactome:REACT_80657 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Bos taurus" xref: Reactome:REACT_80718 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides, Taeniopygia guttata" xref: Reactome:REACT_80779 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Bos taurus" xref: Reactome:REACT_80788 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Rattus norvegicus" xref: Reactome:REACT_80828 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Canis familiaris" xref: Reactome:REACT_80892 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Mus musculus" xref: Reactome:REACT_80961 "Cleavage of C3 by C3 convertases, Mus musculus" xref: Reactome:REACT_81323 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Rattus norvegicus" xref: Reactome:REACT_81333 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Bos taurus" xref: Reactome:REACT_81337 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Taeniopygia guttata" xref: Reactome:REACT_81354 "Notch 2 precursor cleaved to form a heterodimer, Rattus norvegicus" xref: Reactome:REACT_81372 "Part of pro-beta-NGF is processed to mature beta-NGF, Danio rerio" xref: Reactome:REACT_81541 "Cleavage of ATF6-alpha by S1P, Sus scrofa" xref: Reactome:REACT_81561 "pro-prothrombin -> prothrombin + prothrombin propeptide, Gallus gallus" xref: Reactome:REACT_81777 "Activation of C1R, Rattus norvegicus" xref: Reactome:REACT_81795 "pro-protein C -> protein C + protein C propeptide, Mus musculus" xref: Reactome:REACT_81849 "Conversion of C4 into C4a and C4b, Xenopus tropicalis" xref: Reactome:REACT_82153 "Thrombin-mediated activation of Proteinase-activated receptors, Sus scrofa" xref: Reactome:REACT_82158 "Notch 1 precursor cleaved to form a heterodimer, Taeniopygia guttata" xref: Reactome:REACT_82372 "pro-protein C -> protein C + protein C propeptide, Bos taurus" xref: Reactome:REACT_82390 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Mus musculus" xref: Reactome:REACT_82497 "Notch 3 precursor cleaved to form a heterodimer, Rattus norvegicus" xref: Reactome:REACT_82637 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Gallus gallus" xref: Reactome:REACT_82647 "pro-protein Z -> protein Z + protein Z propeptide, Bos taurus" xref: Reactome:REACT_82729 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Xenopus tropicalis" xref: Reactome:REACT_82816 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Danio rerio" xref: Reactome:REACT_82968 "Cleavage of C3 by C3 convertases, Bos taurus" xref: Reactome:REACT_83445 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Canis familiaris" xref: Reactome:REACT_83461 "pro-factor X -> factor X + factor X propeptide, Canis familiaris" xref: Reactome:REACT_83499 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Danio rerio" xref: Reactome:REACT_83770 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Bos taurus" xref: Reactome:REACT_83777 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Danio rerio" xref: Reactome:REACT_84044 "Cleavage of C3 by C3 convertases, Danio rerio" xref: Reactome:REACT_84046 "Activation of C5, Bos taurus" xref: Reactome:REACT_84129 "Processing of classical PDGFs, Rattus norvegicus" xref: Reactome:REACT_84217 "Processing of classical PDGFs, Canis familiaris" xref: Reactome:REACT_84258 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Mus musculus" xref: Reactome:REACT_84261 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Xenopus tropicalis" xref: Reactome:REACT_84305 "pro-factor X -> factor X + factor X propeptide, Sus scrofa" xref: Reactome:REACT_84322 "pro-protein S -> protein S + protein S propeptide, Canis familiaris" xref: Reactome:REACT_84434 "Activation of C5, Mus musculus" xref: Reactome:REACT_84524 "Factor D cleaves C3b-bound Factor B, Sus scrofa" xref: Reactome:REACT_84531 "factor Va -> factor Vi, Canis familiaris" xref: Reactome:REACT_84561 "Formation of alternate C5 convertase, Bos taurus" xref: Reactome:REACT_84599 "Processing of preproGIP to proGIP, Mus musculus" xref: Reactome:REACT_84623 "Activation of C1R, Mus musculus" xref: Reactome:REACT_84646 "factor V -> factor Va + factor V activation peptide, Xenopus tropicalis" xref: Reactome:REACT_84664 "Latent TGF-beta1 is cleaved by furin, Mus musculus" xref: Reactome:REACT_84693 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Mus musculus" xref: Reactome:REACT_84795 "Conversion of C4 into C4a and C4b, Sus scrofa" xref: Reactome:REACT_84822 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Sus scrofa" xref: Reactome:REACT_85002 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Mus musculus" xref: Reactome:REACT_85145 "factor VII -> factor VIIa, Xenopus tropicalis" xref: Reactome:REACT_85207 "pro-protein S -> protein S + protein S propeptide, Taeniopygia guttata" xref: Reactome:REACT_85433 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Gallus gallus" xref: Reactome:REACT_85582 "Processing of Proinsulin to Insulin, Mus musculus" xref: Reactome:REACT_85635 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Gallus gallus" xref: Reactome:REACT_85732 "pro-protein S -> protein S + protein S propeptide, Bos taurus" xref: Reactome:REACT_85824 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Sus scrofa" xref: Reactome:REACT_85897 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Gallus gallus" xref: Reactome:REACT_85916 "pro-protein C -> protein C + protein C propeptide, Danio rerio" xref: Reactome:REACT_86048 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Danio rerio" xref: Reactome:REACT_86053 "pro-factor VII -> factor VII + factor VII propeptide, Mus musculus" xref: Reactome:REACT_86117 "Granzyme-B activates BID by cleavage, Rattus norvegicus" xref: Reactome:REACT_86243 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Mus musculus" xref: Reactome:REACT_86385 "Notch 1 precursor cleaved to form a heterodimer, Xenopus tropicalis" xref: Reactome:REACT_86440 "Notch 2 precursor cleaved to form a heterodimer, Sus scrofa" xref: Reactome:REACT_86442 "Notch 3 precursor cleaved to form a heterodimer, Xenopus tropicalis" xref: Reactome:REACT_86459 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Xenopus tropicalis" xref: Reactome:REACT_86497 "Activation of C1S, Bos taurus" xref: Reactome:REACT_86530 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Rattus norvegicus" xref: Reactome:REACT_86627 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Bos taurus" xref: Reactome:REACT_86670 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst), Bos taurus" xref: Reactome:REACT_86747 "pro-factor IX -> factor IX + factor IX propeptide, Bos taurus" xref: Reactome:REACT_86842 "Notch 3 precursor cleaved to form a heterodimer, Danio rerio" xref: Reactome:REACT_86885 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Bos taurus" xref: Reactome:REACT_86898 "factor VII -> factor VIIa, Bos taurus" xref: Reactome:REACT_86969 "factor XII -> factor XIIa, Mus musculus" xref: Reactome:REACT_87075 "pro-factor VII -> factor VII + factor VII propeptide, Rattus norvegicus" xref: Reactome:REACT_87266 "Processing of Proglucagon to Glucagon-like Peptide-1, Danio rerio" xref: Reactome:REACT_87452 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Canis familiaris" xref: Reactome:REACT_87454 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Danio rerio" xref: Reactome:REACT_87599 "pro-prothrombin -> prothrombin + prothrombin propeptide, Xenopus tropicalis" xref: Reactome:REACT_87700 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Rattus norvegicus" xref: Reactome:REACT_87792 "Activation of C5, Sus scrofa" xref: Reactome:REACT_87800 "Notch 2 precursor cleaved to form a heterodimer, Xenopus tropicalis" xref: Reactome:REACT_87920 "Cleavage of ATF6-alpha by S1P, Rattus norvegicus" xref: Reactome:REACT_88355 "Activation of C5, Danio rerio" xref: Reactome:REACT_88360 "Extracellular processing of novel PDGFs, Danio rerio" xref: Reactome:REACT_88496 "Notch 2 precursor cleaved to form a heterodimer, Mus musculus" xref: Reactome:REACT_88788 "Notch 2 precursor cleaved to form a heterodimer, Danio rerio" xref: Reactome:REACT_88823 "Part of pro-beta-NGF is processed to mature beta-NGF, Gallus gallus" xref: Reactome:REACT_88980 "Conversion of C4 into C4a and C4b, Canis familiaris" xref: Reactome:REACT_89126 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Taeniopygia guttata" xref: Reactome:REACT_89188 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst), Rattus norvegicus" xref: Reactome:REACT_89330 "pro-GAS6 -> GAS6 + GAS6 propeptide, Gallus gallus" xref: Reactome:REACT_89358 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Bos taurus" xref: Reactome:REACT_89476 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Bos taurus" xref: Reactome:REACT_89486 "Cleavage of the Signal Peptide of Preproghrelin, Sus scrofa" xref: Reactome:REACT_89678 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Danio rerio" xref: Reactome:REACT_89776 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin, Canis familiaris" xref: Reactome:REACT_89824 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Rattus norvegicus" xref: Reactome:REACT_89888 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Canis familiaris" xref: Reactome:REACT_89976 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Mus musculus" xref: Reactome:REACT_9 "factor VII -> factor VIIa, Homo sapiens" xref: Reactome:REACT_90020 "Notch 1 precursor cleaved to form a heterodimer, Gallus gallus" xref: Reactome:REACT_90057 "Activation of C5, Canis familiaris" xref: Reactome:REACT_90119 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst), Gallus gallus" xref: Reactome:REACT_90443 "Thrombin-mediated activation of Proteinase-activated receptors, Gallus gallus" xref: Reactome:REACT_905 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Homo sapiens" xref: Reactome:REACT_90541 "pro-prothrombin -> prothrombin + prothrombin propeptide, Canis familiaris" xref: Reactome:REACT_90557 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Rattus norvegicus" xref: Reactome:REACT_90602 "Notch 1 precursor cleaved to form a heterodimer, Bos taurus" xref: Reactome:REACT_90751 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Mus musculus" xref: Reactome:REACT_90855 "Latent TGF-beta1 is cleaved by furin, Sus scrofa" xref: Reactome:REACT_90888 "Processing of Proglucagon to Glucagon-like Peptide-1, Bos taurus" xref: Reactome:REACT_90902 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Bos taurus" xref: Reactome:REACT_90939 "pro-factor X -> factor X + factor X propeptide, Danio rerio" xref: Reactome:REACT_91056 "Factor D cleaves C3(H2O)-bound Factor B, Mus musculus" xref: Reactome:REACT_91167 "Part of pro-beta-NGF is processed to mature beta-NGF, Xenopus tropicalis" xref: Reactome:REACT_91387 "Extracellular processing of novel PDGFs, Xenopus tropicalis" xref: Reactome:REACT_91461 "Factor D cleaves C3(H2O)-bound Factor B, Danio rerio" xref: Reactome:REACT_91543 "Cleavage of the Signal Peptide of Preproghrelin, Canis familiaris" xref: Reactome:REACT_91726 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst), Rattus norvegicus" xref: Reactome:REACT_91877 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Rattus norvegicus" xref: Reactome:REACT_92031 "factor V -> factor Va + factor V activation peptide, Danio rerio" xref: Reactome:REACT_92103 "Latent TGF-beta1 is cleaved by furin, Rattus norvegicus" xref: Reactome:REACT_92110 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst), Sus scrofa" xref: Reactome:REACT_92215 "Cleavage of the Signal Peptide of Preproghrelin, Gallus gallus" xref: Reactome:REACT_92228 "pro-protein S -> protein S + protein S propeptide, Gallus gallus" xref: Reactome:REACT_92253 "factor V -> factor Va + factor V activation peptide, Rattus norvegicus" xref: Reactome:REACT_92261 "Notch 4 precursor cleaved to form a heterodimer, Sus scrofa" xref: Reactome:REACT_92422 "pro-protein S -> protein S + protein S propeptide, Xenopus tropicalis" xref: Reactome:REACT_92693 "Latent TGF-beta1 is cleaved by furin, Bos taurus" xref: Reactome:REACT_92748 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Sus scrofa" xref: Reactome:REACT_92823 "Notch 1 precursor cleaved to form a heterodimer, Canis familiaris" xref: Reactome:REACT_92949 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen, Rattus norvegicus" xref: Reactome:REACT_93064 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Gallus gallus" xref: Reactome:REACT_93142 "pro-factor X -> factor X + factor X propeptide, Bos taurus" xref: Reactome:REACT_93274 "Processing of Proinsulin to Insulin, Gallus gallus" xref: Reactome:REACT_93405 "factor VII -> factor VIIa, Mus musculus" xref: Reactome:REACT_93445 "factor XII -> factor XIIa, Canis familiaris" xref: Reactome:REACT_93463 "Notch 1 precursor cleaved to form a heterodimer, Drosophila melanogaster" xref: Reactome:REACT_93480 "factor Va -> factor Vi, Danio rerio" xref: Reactome:REACT_93511 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Rattus norvegicus" xref: Reactome:REACT_93561 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Taeniopygia guttata" xref: Reactome:REACT_93736 "pro-GAS6 -> GAS6 + GAS6 propeptide, Rattus norvegicus" xref: Reactome:REACT_94000 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Rattus norvegicus" xref: Reactome:REACT_94036 "factor VII -> factor VIIa, Gallus gallus" xref: Reactome:REACT_94312 "pro-protein Z -> protein Z + protein Z propeptide, Gallus gallus" xref: Reactome:REACT_94368 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Danio rerio" xref: Reactome:REACT_94599 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Mus musculus" xref: Reactome:REACT_94754 "factor V -> factor Va + factor V activation peptide, Canis familiaris" xref: Reactome:REACT_94901 "Processing of preproGIP to proGIP, Canis familiaris" xref: Reactome:REACT_94902 "Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3, Rattus norvegicus" xref: Reactome:REACT_94933 "Part of pro-beta-NGF is processed to mature beta-NGF, Canis familiaris" xref: Reactome:REACT_94955 "Cleavage of ATF6-alpha by S1P, Xenopus tropicalis" xref: Reactome:REACT_94965 "Formation of alternate C5 convertase, Sus scrofa" xref: Reactome:REACT_95107 "Thrombin-mediated activation of Proteinase-activated receptors, Rattus norvegicus" xref: Reactome:REACT_95139 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst), Canis familiaris" xref: Reactome:REACT_95191 "pro-protein Z -> protein Z + protein Z propeptide, Xenopus tropicalis" xref: Reactome:REACT_95211 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst), Mus musculus" xref: Reactome:REACT_95236 "Proteolytic Cleavage of Glucagon-like Peptide-1 (GLP-1), Taeniopygia guttata" xref: Reactome:REACT_95276 "pro-prothrombin -> prothrombin + prothrombin propeptide, Taeniopygia guttata" xref: Reactome:REACT_95431 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst), Bos taurus" xref: Reactome:REACT_95949 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst), Rattus norvegicus" xref: Reactome:REACT_95979 "pro-GAS6 -> GAS6 + GAS6 propeptide, Mus musculus" xref: Reactome:REACT_96137 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain), Canis familiaris" xref: Reactome:REACT_96193 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Bos taurus" xref: Reactome:REACT_96270 "pro-factor IX -> factor IX + factor IX propeptide, Xenopus tropicalis" xref: Reactome:REACT_96343 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B, Rattus norvegicus" xref: Reactome:REACT_96382 "Factor D cleaves C3b-bound Factor B, Mus musculus" xref: Reactome:REACT_96526 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a, Sus scrofa" xref: Reactome:REACT_97100 "pro-protein Z -> protein Z + protein Z propeptide, Danio rerio" xref: Reactome:REACT_97110 "factor Va -> factor Vi, Xenopus tropicalis" xref: Reactome:REACT_97353 "factor XII -> factor XIIa, Bos taurus" xref: Reactome:REACT_97421 "pro-protein C -> protein C + protein C propeptide, Canis familiaris" xref: Reactome:REACT_97432 "Part of pro-beta-NGF is processed to mature beta-NGF, Bos taurus" xref: Reactome:REACT_97564 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Taeniopygia guttata" xref: Reactome:REACT_97673 "pro-factor VII -> factor VII + factor VII propeptide, Bos taurus" xref: Reactome:REACT_97699 "pro-GAS6 -> GAS6 + GAS6 propeptide, Xenopus tropicalis" xref: Reactome:REACT_97708 "Cleavage of ATF6-alpha by S1P, Bos taurus" xref: Reactome:REACT_97710 "Cleavage of ATF6-alpha by S1P, Mus musculus" xref: Reactome:REACT_97801 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin, Sus scrofa" xref: Reactome:REACT_97855 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR, Canis familiaris" xref: Reactome:REACT_98063 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Cathepsin G, Rattus norvegicus" xref: Reactome:REACT_98097 "Activation of C1S, Xenopus tropicalis" xref: Reactome:REACT_98147 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Thrombin, Gallus gallus" xref: Reactome:REACT_98165 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin, Xenopus tropicalis" xref: Reactome:REACT_98203 "pro-GAS6 -> GAS6 + GAS6 propeptide, Danio rerio" xref: Reactome:REACT_98267 "pro-prothrombin -> prothrombin + prothrombin propeptide, Rattus norvegicus" xref: Reactome:REACT_98357 "pro-prothrombin -> prothrombin + prothrombin propeptide, Danio rerio" xref: Reactome:REACT_98392 "Extracellular processing of novel PDGFs, Rattus norvegicus" xref: Reactome:REACT_98494 "Processing of preproGLP-1 to proGLP-1, Taeniopygia guttata" xref: Reactome:REACT_98565 "Processing of preproGIP to proGIP, Rattus norvegicus" xref: Reactome:REACT_98659 "Factor D cleaves C3(H2O)-bound Factor B, Sus scrofa" xref: Reactome:REACT_98696 "pro-prothrombin -> prothrombin + prothrombin propeptide, Bos taurus" xref: Reactome:REACT_98749 "Proteolytic Cleavage of Glucose-dependent Insulinotropic Polypeptide (GIP), Bos taurus" xref: Reactome:REACT_98786 "Notch 3 precursor cleaved to form a heterodimer, Bos taurus" xref: Reactome:REACT_98917 "Formation of alternate C5 convertase, Canis familiaris" xref: Reactome:REACT_99191 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Plasmin, Mus musculus" xref: Reactome:REACT_99384 "Processing of classical PDGFs, Taeniopygia guttata" xref: Reactome:REACT_99395 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst), Canis familiaris" xref: Reactome:REACT_99405 "Notch 4 precursor cleaved to form a heterodimer, Rattus norvegicus" xref: Reactome:REACT_99429 "Processing of Proglucagon to Glucagon-like Peptide-1, Xenopus tropicalis" xref: Reactome:REACT_99443 "Cleavage of the Signal Peptide of Preproghrelin, Rattus norvegicus" xref: Reactome:REACT_99555 "pro-protein Z -> protein Z + protein Z propeptide, Taeniopygia guttata" xref: Reactome:REACT_99585 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin, Rattus norvegicus" xref: Reactome:REACT_99900 "protein C -> activated protein C + protein C heavy chain activation peptide, Mus musculus" xref: Reactome:REACT_99921 "Granzyme-B activates BID by cleavage, Bos taurus" xref: Reactome:REACT_99987 "Notch 2 precursor cleaved to form a heterodimer, Bos taurus" is_a: GO:0008233 ! peptidase activity [Term] id: GO:0004301 name: epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] subset: goslim_chembl synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "sEH" RELATED [EC:3.3.2.10] synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10] xref: EC:3.3.2.10 xref: MetaCyc:3.3.2.10-RXN xref: UM-BBD_enzymeID:e0397 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0004386 name: helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast xref: Reactome:REACT_101111 "Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae" xref: Reactome:REACT_101247 "Formation of open bubble structure in DNA by helicases, Bos taurus" xref: Reactome:REACT_101622 "MCM8 mediated fork unwinding, Danio rerio" xref: Reactome:REACT_101644 "Formation of open bubble structure in DNA by helicases, Oryza sativa" xref: Reactome:REACT_101823 "MCM2-7 mediated fork unwinding, Plasmodium falciparum" xref: Reactome:REACT_101994 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis" xref: Reactome:REACT_102121 "Addition of the third nucleotide on the nascent transcript, Rattus norvegicus" xref: Reactome:REACT_102441 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus" xref: Reactome:REACT_102560 "MCM2-7 mediated fork unwinding, Oryza sativa" xref: Reactome:REACT_1033 "Formation of open bubble structure in DNA by helicases, Homo sapiens" xref: Reactome:REACT_103861 "MCM8 mediated fork unwinding, Bos taurus" xref: Reactome:REACT_103881 "RNA Polymerase II Promoter Opening: First Transition, Dictyostelium discoideum" xref: Reactome:REACT_103897 "MCM8 mediated fork unwinding, Mus musculus" xref: Reactome:REACT_103959 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus" xref: Reactome:REACT_104221 "MCM2-7 mediated fork unwinding, Rattus norvegicus" xref: Reactome:REACT_105950 "MCM2-7 mediated fork unwinding, Xenopus tropicalis" xref: Reactome:REACT_106346 "Formation of open bubble structure in DNA by helicases, Taeniopygia guttata" xref: Reactome:REACT_107072 "Formation of open bubble structure in DNA by helicases, Mus musculus" xref: Reactome:REACT_107495 "RNA Polymerase II Promoter Opening: First Transition, Taeniopygia guttata" xref: Reactome:REACT_108159 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum" xref: Reactome:REACT_108648 "Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana" xref: Reactome:REACT_108654 "MCM2-7 mediated fork unwinding, Schizosaccharomyces pombe" xref: Reactome:REACT_109035 "RNA Polymerase II Promoter Opening: First Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_109161 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana" xref: Reactome:REACT_110588 "MCM8 mediated fork unwinding, Xenopus tropicalis" xref: Reactome:REACT_110827 "Formation of open bubble structure in DNA by helicases, Danio rerio" xref: Reactome:REACT_110845 "Cap-bound mRNA is activated by helicases, Mus musculus" xref: Reactome:REACT_112208 "MCM8 mediated fork unwinding, Drosophila melanogaster" xref: Reactome:REACT_112817 "Cap-bound mRNA is activated by helicases, Schizosaccharomyces pombe" xref: Reactome:REACT_113177 "Formation of open bubble structure in DNA by helicases, Caenorhabditis elegans" xref: Reactome:REACT_1521 "Cap-bound mRNA is activated by helicases, Homo sapiens" xref: Reactome:REACT_1817 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_1844 "RNA Polymerase II Promoter Opening: First Transition, Homo sapiens" xref: Reactome:REACT_28131 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster" xref: Reactome:REACT_28343 "MCM2-7 mediated fork unwinding, Danio rerio" xref: Reactome:REACT_28810 "Addition of the third nucleotide on the nascent transcript, Oryza sativa" xref: Reactome:REACT_28880 "MCM2-7 mediated fork unwinding, Drosophila melanogaster" xref: Reactome:REACT_29155 "Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster" xref: Reactome:REACT_29217 "Formation of open bubble structure in DNA by helicases, Xenopus tropicalis" xref: Reactome:REACT_29818 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa" xref: Reactome:REACT_29850 "RNA Polymerase II Promoter Opening: First Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_30013 "MCM8 mediated fork unwinding, Rattus norvegicus" xref: Reactome:REACT_30989 "MCM8 mediated fork unwinding, Arabidopsis thaliana" xref: Reactome:REACT_31034 "Cap-bound mRNA is activated by helicases, Danio rerio" xref: Reactome:REACT_31090 "MCM2-7 mediated fork unwinding, Gallus gallus" xref: Reactome:REACT_31554 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_32533 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans" xref: Reactome:REACT_33205 "MCM8 mediated fork unwinding, Canis familiaris" xref: Reactome:REACT_34016 "Formation of open bubble structure in DNA by helicases, Rattus norvegicus" xref: Reactome:REACT_34089 "MCM2-7 mediated fork unwinding, Dictyostelium discoideum" xref: Reactome:REACT_34560 "MCM8 mediated fork unwinding, Sus scrofa" xref: Reactome:REACT_40 "Addition of the third nucleotide on the nascent transcript, Homo sapiens" xref: Reactome:REACT_6134 "HIV-1 Promoter Opening: First Transition, Homo sapiens" xref: Reactome:REACT_6184 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_6325 "Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_6758 "Xenopus Mcm8 mediated fork unwinding, Xenopus laevis" xref: Reactome:REACT_6768 "MCM8 mediated fork unwinding, Homo sapiens" xref: Reactome:REACT_6853 "Yeast Mcm2-7 mediated fork unwinding, Saccharomyces cerevisiae" xref: Reactome:REACT_6922 "MCM2-7 mediated fork unwinding, Homo sapiens" xref: Reactome:REACT_78086 "RNA Polymerase II Promoter Opening: First Transition, Rattus norvegicus" xref: Reactome:REACT_78462 "Formation of open bubble structure in DNA by helicases, Drosophila melanogaster" xref: Reactome:REACT_78667 "MCM2-7 mediated fork unwinding, Canis familiaris" xref: Reactome:REACT_78771 "MCM8 mediated fork unwinding, Dictyostelium discoideum" xref: Reactome:REACT_79759 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus" xref: Reactome:REACT_80107 "RNA Polymerase II Promoter Opening: First Transition, Arabidopsis thaliana" xref: Reactome:REACT_80325 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio" xref: Reactome:REACT_80500 "MCM8 mediated fork unwinding, Gallus gallus" xref: Reactome:REACT_80532 "Addition of the third nucleotide on the nascent transcript, Gallus gallus" xref: Reactome:REACT_80605 "Addition of the third nucleotide on the nascent transcript, Mus musculus" xref: Reactome:REACT_81126 "Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe" xref: Reactome:REACT_81335 "RNA Polymerase II Promoter Opening: First Transition, Gallus gallus" xref: Reactome:REACT_81427 "MCM8 mediated fork unwinding, Taeniopygia guttata" xref: Reactome:REACT_81441 "MCM8 mediated fork unwinding, Oryza sativa" xref: Reactome:REACT_81682 "Formation of open bubble structure in DNA by helicases, Canis familiaris" xref: Reactome:REACT_82776 "RNA Polymerase II Promoter Opening: First Transition, Danio rerio" xref: Reactome:REACT_83794 "Formation of open bubble structure in DNA by helicases, Gallus gallus" xref: Reactome:REACT_84565 "Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe" xref: Reactome:REACT_84574 "Cap-bound mRNA is activated by helicases, Canis familiaris" xref: Reactome:REACT_84809 "MCM2-7 mediated fork unwinding, Mus musculus" xref: Reactome:REACT_84907 "MCM2-7 mediated fork unwinding, Taeniopygia guttata" xref: Reactome:REACT_85111 "Cap-bound mRNA is activated by helicases, Drosophila melanogaster" xref: Reactome:REACT_85172 "MCM2-7 mediated fork unwinding, Arabidopsis thaliana" xref: Reactome:REACT_86220 "MCM2-7 mediated fork unwinding, Caenorhabditis elegans" xref: Reactome:REACT_88362 "Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans" xref: Reactome:REACT_89000 "MCM2-7 mediated fork unwinding, Bos taurus" xref: Reactome:REACT_89030 "Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae" xref: Reactome:REACT_89363 "Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis" xref: Reactome:REACT_89694 "RNA Polymerase II Promoter Opening: First Transition, Drosophila melanogaster" xref: Reactome:REACT_91822 "MCM8 mediated fork unwinding, Plasmodium falciparum" xref: Reactome:REACT_93391 "RNA Polymerase II Promoter Opening: First Transition, Oryza sativa" xref: Reactome:REACT_93711 "RNA Polymerase II Promoter Opening: First Transition, Mus musculus" xref: Reactome:REACT_94645 "RNA Polymerase II Promoter Opening: First Transition, Xenopus tropicalis" xref: Reactome:REACT_94679 "RNA Polymerase II Promoter Opening: First Transition, Caenorhabditis elegans" xref: Reactome:REACT_95942 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_95993 "Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana" xref: Reactome:REACT_98273 "Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum" xref: Reactome:REACT_98302 "Formation of open bubble structure in DNA by helicases, Sus scrofa" xref: Reactome:REACT_98745 "Cap-bound mRNA is activated by helicases, Xenopus tropicalis" xref: Reactome:REACT_99120 "Addition of the third nucleotide on the nascent transcript, Danio rerio" is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0004453 name: juvenile-hormone esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352] subset: goslim_chembl synonym: "JH esterase activity" EXACT [EC:3.1.1.59] synonym: "JH-esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59] synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59] xref: EC:3.1.1.59 xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN xref: RHEA:16393 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast xref: EC:3.1 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds relationship: part_of GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0004620 name: phospholipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732] subset: goslim_chembl xref: EC:3.1.1 is_a: GO:0016298 ! lipase activity [Term] id: GO:0004622 name: lysophospholipase activity namespace: molecular_function alt_id: GO:0045126 def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] subset: goslim_chembl synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5] synonym: "lecithinase B activity" EXACT [EC:3.1.1.5] synonym: "lecitholipase activity" EXACT [EC:3.1.1.5] synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5] synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5] synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5] synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] synonym: "phosphatidase B" RELATED [EC:3.1.1.5] synonym: "phospholipase B activity" EXACT [EC:3.1.1.5] xref: EC:3.1.1.5 xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN xref: RHEA:15177 is_a: GO:0004620 ! phospholipase activity [Term] id: GO:0004623 name: phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] subset: goslim_chembl synonym: "cytosolic phospholipase A2 activity" NARROW [] synonym: "lecithinase A activity" EXACT [EC:3.1.1.4] synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4] synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4] synonym: "phospholipase A" RELATED [EC:3.1.1.4] synonym: "secreted phospholipase A2 activity" NARROW [] xref: EC:3.1.1.4 xref: MetaCyc:PHOSPHOLIPASE-A2-RXN xref: RHEA:15801 is_a: GO:0004620 ! phospholipase activity [Term] id: GO:0004630 name: phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4] subset: goslim_chembl synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4] synonym: "lecithinase D activity" EXACT [EC:3.1.4.4] synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4] synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4] xref: EC:3.1.4.4 xref: MetaCyc:PHOSCHOL-RXN is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004767 name: sphingomyelin phosphodiesterase activity namespace: molecular_function alt_id: GO:0030230 alt_id: GO:0030231 def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19253] subset: goslim_chembl synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12] synonym: "sphingomyelinase activity" EXACT [] xref: EC:3.1.4.12 xref: KEGG:R02541 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN xref: Reactome:REACT_106320 "Production of ceramide which can activate JNK and other targets, Taeniopygia guttata" xref: Reactome:REACT_106769 "Production of ceramide which can activate JNK and other targets, Saccharomyces cerevisiae" xref: Reactome:REACT_110644 "Production of ceramide which can activate JNK and other targets, Xenopus tropicalis" xref: Reactome:REACT_115560 "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin, Homo sapiens" xref: Reactome:REACT_115857 "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane), Homo sapiens" xref: Reactome:REACT_116064 "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane), Homo sapiens" xref: Reactome:REACT_116148 "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome), Homo sapiens" xref: Reactome:REACT_13750 "Production of ceramide which can activate JNK and other targets, Rattus norvegicus" xref: Reactome:REACT_13752 "Production of ceramide which can activate JNK and other targets, Homo sapiens" xref: Reactome:REACT_29592 "Production of ceramide which can activate JNK and other targets, Danio rerio" xref: Reactome:REACT_30235 "Production of ceramide which can activate JNK and other targets, Drosophila melanogaster" xref: Reactome:REACT_31542 "Production of ceramide which can activate JNK and other targets, Caenorhabditis elegans" xref: Reactome:REACT_33689 "Production of ceramide which can activate JNK and other targets, Bos taurus" xref: Reactome:REACT_34798 "Production of ceramide which can activate JNK and other targets, Canis familiaris" xref: Reactome:REACT_84506 "Production of ceramide which can activate JNK and other targets, Mus musculus" xref: Reactome:REACT_88771 "Production of ceramide which can activate JNK and other targets, Sus scrofa" xref: Reactome:REACT_91464 "Production of ceramide which can activate JNK and other targets, Gallus gallus" xref: Reactome:REACT_91647 "Production of ceramide which can activate JNK and other targets, Schizosaccharomyces pombe" xref: RHEA:19253 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004771 name: sterol esterase activity namespace: molecular_function def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] subset: goslim_chembl synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13] synonym: "cholesterase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13] synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13] synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13] xref: EC:3.1.1.13 xref: MetaCyc:STEROL-ESTERASE-RXN xref: Reactome:REACT_108039 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Bos taurus" xref: Reactome:REACT_110768 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Gallus gallus" xref: Reactome:REACT_28907 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Taeniopygia guttata" xref: Reactome:REACT_32955 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Canis familiaris" xref: Reactome:REACT_59464 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Mus musculus" xref: Reactome:REACT_82975 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Rattus norvegicus" xref: Reactome:REACT_87504 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Danio rerio" xref: Reactome:REACT_9468 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Homo sapiens" xref: Reactome:REACT_97257 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase), Xenopus tropicalis" is_a: GO:0016298 ! lipase activity [Term] id: GO:0004806 name: triglyceride lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] subset: goslim_chembl synonym: "amano AP" RELATED [EC:3.1.1.3] synonym: "amano B" RELATED [EC:3.1.1.3] synonym: "amano CE" RELATED [EC:3.1.1.3] synonym: "amano CES" RELATED [EC:3.1.1.3] synonym: "amano P" RELATED [EC:3.1.1.3] synonym: "amno N-AP" RELATED [EC:3.1.1.3] synonym: "butyrinase activity" EXACT [EC:3.1.1.3] synonym: "cacordase activity" EXACT [EC:3.1.1.3] synonym: "capalase L" RELATED [EC:3.1.1.3] synonym: "GA 56" RELATED [EC:3.1.1.3] synonym: "GEH" RELATED [EC:3.1.1.3] synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] synonym: "lipazin" RELATED [EC:3.1.1.3] synonym: "liver lipase" NARROW [EC:3.1.1.3] synonym: "meito MY 30" RELATED [EC:3.1.1.3] synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] synonym: "PPL" RELATED [EC:3.1.1.3] synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] synonym: "steapsin" RELATED [EC:3.1.1.3] synonym: "TAG activity" EXACT [PMID:16054079] synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] synonym: "triacetinase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol lipase activity" EXACT [EC:3.1.1.3] synonym: "tributyrase activity" RELATED [EC:3.1.1.3] synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3] synonym: "tributyrinase activity" EXACT [EC:3.1.1.3] synonym: "triglyceridase activity" EXACT [EC:3.1.1.3] synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3] synonym: "tweenase activity" EXACT [EC:3.1.1.3] synonym: "tweenesterase activity" EXACT [EC:3.1.1.3] xref: EC:3.1.1.3 xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN xref: Reactome:REACT_100562 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Caenorhabditis elegans" xref: Reactome:REACT_109925 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Canis familiaris" xref: Reactome:REACT_113800 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Danio rerio" xref: Reactome:REACT_1694 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Rattus norvegicus" xref: Reactome:REACT_34739 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Bos taurus" xref: Reactome:REACT_538 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Homo sapiens" xref: Reactome:REACT_77800 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Mus musculus" xref: Reactome:REACT_92207 "triacylglycerol + H2O -> diacylglycerol + fatty acid, Xenopus tropicalis" xref: RHEA:12044 is_a: GO:0016298 ! lipase activity [Term] id: GO:0004873 name: asialoglycoprotein receptor activity namespace: molecular_function def: "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane." [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein] subset: goslim_chembl is_a: GO:0003674 ! molecular_function relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0004930 name: G protein-coupled receptor activity namespace: molecular_function alt_id: GO:0001622 alt_id: GO:0001623 alt_id: GO:0001624 alt_id: GO:0001625 alt_id: GO:0016526 def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] subset: goslim_chembl synonym: "EBV-induced receptor" NARROW [] synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "Mas proto-oncogene receptor activity" NARROW [] synonym: "orphan G protein coupled receptor activity" NARROW [] synonym: "orphan G-protein coupled receptor activity" NARROW [] synonym: "orphan GPCR activity" NARROW [] synonym: "RDC1 receptor activity" NARROW [] synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "SREB receptor" NARROW [] synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] xref: Reactome:REACT_100062 "G12/13 activation by PAR, Sus scrofa" xref: Reactome:REACT_100632 "The high affinity receptor complex binds to G-protein, Mus musculus" xref: Reactome:REACT_101654 "G12/13 activation by PAR, Taeniopygia guttata" xref: Reactome:REACT_108337 "Gq activation by PAR, Gallus gallus" xref: Reactome:REACT_108705 "The high affinity receptor complex binds to G-protein, Gallus gallus" xref: Reactome:REACT_109480 "Gq activation by PAR, Bos taurus" xref: Reactome:REACT_109715 "The high affinity receptor complex binds to G-protein, Danio rerio" xref: Reactome:REACT_110075 "G12/13 activation by PAR, Bos taurus" xref: Reactome:REACT_1430 "Gq activation by PAR, Homo sapiens" xref: Reactome:REACT_15298 "The high affinity receptor complex binds to G-protein, Homo sapiens" xref: Reactome:REACT_28243 "Gq activation by PAR, Rattus norvegicus" xref: Reactome:REACT_29193 "G12/13 activation by PAR, Rattus norvegicus" xref: Reactome:REACT_29686 "Gq activation by PAR, Canis familiaris" xref: Reactome:REACT_30471 "G12/13 activation by PAR, Mus musculus" xref: Reactome:REACT_32708 "G12/13 activation by PAR, Canis familiaris" xref: Reactome:REACT_32983 "Gq activation by PAR, Danio rerio" xref: Reactome:REACT_34075 "The high affinity receptor complex binds to G-protein, Taeniopygia guttata" xref: Reactome:REACT_637 "G12/13 activation by PAR, Homo sapiens" xref: Reactome:REACT_77079 "G12/13 activation by PAR, Danio rerio" xref: Reactome:REACT_78692 "The high affinity receptor complex binds to G-protein, Xenopus tropicalis" xref: Reactome:REACT_79526 "Gq activation by PAR, Sus scrofa" xref: Reactome:REACT_85249 "The high affinity receptor complex binds to G-protein, Canis familiaris" xref: Reactome:REACT_85989 "Gq activation by PAR, Taeniopygia guttata" xref: Reactome:REACT_86240 "G12/13 activation by PAR, Gallus gallus" xref: Reactome:REACT_92494 "The high affinity receptor complex binds to G-protein, Bos taurus" xref: Reactome:REACT_95526 "Gq activation by PAR, Mus musculus" xref: Reactome:REACT_97825 "Gq activation by PAR, Xenopus tropicalis" xref: Reactome:REACT_98882 "G12/13 activation by PAR, Xenopus tropicalis" xref: Wikipedia:GPCR is_a: GO:0038023 ! signaling receptor activity relationship: part_of GO:0007165 ! signal transduction [Term] id: GO:0005044 name: scavenger receptor activity namespace: molecular_function def: "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children. subset: goslim_chembl synonym: "macrophage receptor activity" NARROW [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0005085 name: guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0008433 alt_id: GO:0016219 alt_id: GO:0019839 def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] comment: Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product. subset: goslim_chembl subset: goslim_yeast synonym: "GDP-dissociation stimulator activity" EXACT [] synonym: "GDS" EXACT [] synonym: "GEF" EXACT [] synonym: "GNRP" NARROW [] synonym: "guanyl-nucleotide release factor activity" EXACT [] synonym: "guanyl-nucleotide releasing factor" EXACT [] xref: Reactome:REACT_100054 "Liganded Gs-activating GPCR acts as a GEF for Gs, Gallus gallus" xref: Reactome:REACT_100149 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Bos taurus" xref: Reactome:REACT_100160 "Liganded Gi-activating GPCR acts as a GEF for Gi, Dictyostelium discoideum" xref: Reactome:REACT_100220 "Liganded Gs-activating GPCR acts as a GEF for Gs, Sus scrofa" xref: Reactome:REACT_100376 "C3G stimulates nucleotide exchange on Rap1, Bos taurus" xref: Reactome:REACT_100844 "Activation of Cdc42 by pVav1, Rattus norvegicus" xref: Reactome:REACT_100845 "Gi activation by P2Y purinoceptor 12, Gallus gallus" xref: Reactome:REACT_100865 "Gq activation by P2Y purinoceptor 1, Rattus norvegicus" xref: Reactome:REACT_101114 "Activation of Rap1 by membrane-associated GEFs, Sus scrofa" xref: Reactome:REACT_101120 "Liganded Gi-activating GPCR acts as a GEF for Gi, Bos taurus" xref: Reactome:REACT_101134 "Opsins that act as GEFs for G alpha-t, Mus musculus" xref: Reactome:REACT_101148 "Activation of Rap1 by membrane-associated GEFs, Rattus norvegicus" xref: Reactome:REACT_101201 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Xenopus tropicalis" xref: Reactome:REACT_101347 "Liganded Gz-activating GPCR acts as a GEF for Gz, Mus musculus" xref: Reactome:REACT_101383 "Gs activation by prostacyclin receptor, Danio rerio" xref: Reactome:REACT_101464 "Activation of Rap1 by membrane-associated GEFs, Caenorhabditis elegans" xref: Reactome:REACT_101601 "Activation of Rac1 by pVav1, Rattus norvegicus" xref: Reactome:REACT_102077 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Sus scrofa" xref: Reactome:REACT_102765 "Activation of Rac1 by pVav1, Gallus gallus" xref: Reactome:REACT_103302 "Sar1p Activation And Membrane Binding, Danio rerio" xref: Reactome:REACT_103339 "Liganded Gi-activating GPCR acts as a GEF for Gi, Taeniopygia guttata" xref: Reactome:REACT_103405 "Activation of Cdc42 by pVav1, Xenopus tropicalis" xref: Reactome:REACT_103624 "C3G stimulates nucleotide exchange on Rap1, Rattus norvegicus" xref: Reactome:REACT_103967 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Taeniopygia guttata" xref: Reactome:REACT_104045 "Liganded Gz-activating GPCR acts as a GEF for Gz, Bos taurus" xref: Reactome:REACT_104400 "p115-RhoGEF activation of Rac1, Canis familiaris" xref: Reactome:REACT_104431 "G13 activation by TP receptor, Rattus norvegicus" xref: Reactome:REACT_104640 "G13 activation by TP receptor, Danio rerio" xref: Reactome:REACT_104773 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Gallus gallus" xref: Reactome:REACT_105341 "VAV2 is a GEF for Rho/Rac family kinases, Caenorhabditis elegans" xref: Reactome:REACT_105372 "Gq activation by P2Y purinoceptor 1, Xenopus tropicalis" xref: Reactome:REACT_105430 "Gq activation by P2Y purinoceptor 1, Danio rerio" xref: Reactome:REACT_105942 "Opsins that act as GEFs for G alpha-t, Danio rerio" xref: Reactome:REACT_106103 "Liganded Gi-activating GPCR acts as a GEF for Gi, Sus scrofa" xref: Reactome:REACT_106278 "Activation of Rap1 by cytosolic GEFs, Bos taurus" xref: Reactome:REACT_106432 "Liganded Gi-activating GPCR acts as a GEF for Gi, Gallus gallus" xref: Reactome:REACT_106521 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Rattus norvegicus" xref: Reactome:REACT_106839 "Activation of Rac1 by pVav1, Taeniopygia guttata" xref: Reactome:REACT_106962 "Gq activation by TP receptor, Mus musculus" xref: Reactome:REACT_107078 "Activation of Rac1 by pVav1, Canis familiaris" xref: Reactome:REACT_107457 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Xenopus tropicalis" xref: Reactome:REACT_108239 "Opsins that act as GEFs for G alpha-t, Bos taurus" xref: Reactome:REACT_108491 "VAV2 is a GEF for Rho/Rac family kinases, Taeniopygia guttata" xref: Reactome:REACT_108921 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Canis familiaris" xref: Reactome:REACT_109910 "Liganded Gz-activating GPCR acts as a GEF for Gz, Gallus gallus" xref: Reactome:REACT_109998 "Gi activation by P2Y purinoceptor 12, Bos taurus" xref: Reactome:REACT_110266 "Liganded Gs-activating GPCR acts as a GEF for Gs, Mus musculus" xref: Reactome:REACT_110292 "Gs activation by prostacyclin receptor, Taeniopygia guttata" xref: Reactome:REACT_110300 "Sar1p Activation And Membrane Binding, Oryza sativa" xref: Reactome:REACT_110415 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Mus musculus" xref: Reactome:REACT_110820 "C3G stimulates nucleotide exchange on Rap1, Gallus gallus" xref: Reactome:REACT_110821 "VAV3 is a GEF for Rho/Rac family kinases, Rattus norvegicus" xref: Reactome:REACT_111195 "Activation of RAC1, Homo sapiens" xref: Reactome:REACT_112168 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Danio rerio" xref: Reactome:REACT_112243 "Activation of RAC1, Xenopus tropicalis" xref: Reactome:REACT_112276 "VAV2 is a GEF for Rho/Rac family kinases, Schizosaccharomyces pombe" xref: Reactome:REACT_112354 "Activation of RAC1, Mus musculus" xref: Reactome:REACT_113007 "Activation of RAC1, Canis familiaris" xref: Reactome:REACT_113090 "p115-RhoGEF activation of Rac1, Caenorhabditis elegans" xref: Reactome:REACT_113408 "VAV2 is a GEF for Rho/Rac family kinases, Saccharomyces cerevisiae" xref: Reactome:REACT_113526 "Activation of Rap1 by membrane-associated GEFs, Drosophila melanogaster" xref: Reactome:REACT_113541 "p115-RhoGEF activation of Rac1, Xenopus tropicalis" xref: Reactome:REACT_113598 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Dictyostelium discoideum" xref: Reactome:REACT_114659 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Danio rerio" xref: Reactome:REACT_114904 "VAV3 is a GEF for Rho/Rac family kinases, Saccharomyces cerevisiae" xref: Reactome:REACT_115094 "VAV1 is a GEF for Rho/Rac family kinases, Caenorhabditis elegans" xref: Reactome:REACT_115111 "VAV3 is a GEF for Rho/Rac family kinases, Schizosaccharomyces pombe" xref: Reactome:REACT_115210 "Activation of RAC1, Drosophila melanogaster" xref: Reactome:REACT_115748 "Rit is activated, Rattus norvegicus" xref: Reactome:REACT_12037 "C3G stimulates nucleotide exchange on Rap1, Homo sapiens" xref: Reactome:REACT_12071 "RIT/RIN are activated, Homo sapiens" xref: Reactome:REACT_12083 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Homo sapiens" xref: Reactome:REACT_1214 "p115-RhoGEF activation of Rac1, Homo sapiens" xref: Reactome:REACT_12453 "C3G stimulates nucleotide exchange on Rap1, Rattus norvegicus" xref: Reactome:REACT_12554 "Sar1p Activation And Membrane Binding, Homo sapiens" xref: Reactome:REACT_13694 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Homo sapiens" xref: Reactome:REACT_15291 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Homo sapiens" xref: Reactome:REACT_15507 "Activation of Rap1 by cytosolic GEFs, Homo sapiens" xref: Reactome:REACT_15538 "Liganded Gi-activating GPCR acts as a GEF for Gi, Homo sapiens" xref: Reactome:REACT_17008 "Liganded Gs-activating GPCR acts as a GEF for Gs, Homo sapiens" xref: Reactome:REACT_18309 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Homo sapiens" xref: Reactome:REACT_18400 "Opsins that act as GEFs for G alpha-t, Homo sapiens" xref: Reactome:REACT_19243 "Activation of Rac1 by pVav1, Homo sapiens" xref: Reactome:REACT_19286 "Activation of Cdc42 by pVav1, Homo sapiens" xref: Reactome:REACT_19346 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Homo sapiens" xref: Reactome:REACT_20507 "Gi activation by P2Y purinoceptor 12, Homo sapiens" xref: Reactome:REACT_20511 "Gq activation by TP receptor, Homo sapiens" xref: Reactome:REACT_20567 "G13 activation by TP receptor, Homo sapiens" xref: Reactome:REACT_20636 "Gq activation by P2Y purinoceptor 1, Homo sapiens" xref: Reactome:REACT_22110 "Glucagon:GCGR mediates GTP-GDP exchange, Homo sapiens" xref: Reactome:REACT_22134 "Activation of Gq by Muscarinic Acetylcholine Receptor M3 (mouse), Mus musculus" xref: Reactome:REACT_22180 "Activation of Rac1 by VAV2, Homo sapiens" xref: Reactome:REACT_22370 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Homo sapiens" xref: Reactome:REACT_22380 "Liganded Gz-activating GPCR acts as a GEF for Gz, Homo sapiens" xref: Reactome:REACT_23806 "VAV2 is a GEF for Rho/Rac family kinases, Homo sapiens" xref: Reactome:REACT_23823 "Gs activation by prostacyclin receptor, Homo sapiens" xref: Reactome:REACT_23833 "Activation of Rap1 by membrane-associated GEFs, Homo sapiens" xref: Reactome:REACT_23936 "VAV3 is a GEF for Rho/Rac family kinases, Homo sapiens" xref: Reactome:REACT_24016 "VAV1 is a GEF for Rho/Rac family kinases, Homo sapiens" xref: Reactome:REACT_28676 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Bos taurus" xref: Reactome:REACT_29276 "VAV2 is a GEF for Rho/Rac family kinases, Bos taurus" xref: Reactome:REACT_29380 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Sus scrofa" xref: Reactome:REACT_29556 "Regeneration of eEF1A:GTP by eEF1B activity, Mus musculus" xref: Reactome:REACT_29675 "Liganded Gs-activating GPCR acts as a GEF for Gs, Xenopus tropicalis" xref: Reactome:REACT_30010 "Liganded Gi-activating GPCR acts as a GEF for Gi, Mus musculus" xref: Reactome:REACT_30405 "Gq activation by TP receptor, Gallus gallus" xref: Reactome:REACT_30438 "VAV1 is a GEF for Rho/Rac family kinases, Xenopus tropicalis" xref: Reactome:REACT_30603 "Liganded Gs-activating GPCR acts as a GEF for Gs, Taeniopygia guttata" xref: Reactome:REACT_30730 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Drosophila melanogaster" xref: Reactome:REACT_30735 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Canis familiaris" xref: Reactome:REACT_30905 "Opsins that act as GEFs for G alpha-t, Canis familiaris" xref: Reactome:REACT_31044 "Sar1p Activation And Membrane Binding, Sus scrofa" xref: Reactome:REACT_31228 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Gallus gallus" xref: Reactome:REACT_31456 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Mus musculus" xref: Reactome:REACT_31493 "VAV3 is a GEF for Rho/Rac family kinases, Drosophila melanogaster" xref: Reactome:REACT_31796 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Bos taurus" xref: Reactome:REACT_31909 "Liganded Gz-activating GPCR acts as a GEF for Gz, Rattus norvegicus" xref: Reactome:REACT_32415 "VAV2 is a GEF for Rho/Rac family kinases, Gallus gallus" xref: Reactome:REACT_33219 "Gi activation by P2Y purinoceptor 12, Canis familiaris" xref: Reactome:REACT_33232 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Xenopus tropicalis" xref: Reactome:REACT_33439 "Activation of Rac1 by pVav1, Bos taurus" xref: Reactome:REACT_33449 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Danio rerio" xref: Reactome:REACT_33674 "p115-RhoGEF activation of Rac1, Drosophila melanogaster" xref: Reactome:REACT_33737 "G13 activation by TP receptor, Taeniopygia guttata" xref: Reactome:REACT_34008 "Activation of Rap1 by cytosolic GEFs, Xenopus tropicalis" xref: Reactome:REACT_34487 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Gallus gallus" xref: Reactome:REACT_36332 "Sar1p Activation And Membrane Binding, Bos taurus" xref: Reactome:REACT_44918 "Gi activation by P2Y purinoceptor 12, Rattus norvegicus" xref: Reactome:REACT_6224 "GDP is exchanged for GTP on DRheb, Drosophila melanogaster" xref: Reactome:REACT_67 "Regeneration of eEF1A:GTP by eEF1B activity, Homo sapiens" xref: Reactome:REACT_77041 "Sar1p Activation And Membrane Binding, Canis familiaris" xref: Reactome:REACT_77066 "Liganded Gz-activating GPCR acts as a GEF for Gz, Taeniopygia guttata" xref: Reactome:REACT_77652 "G13 activation by TP receptor, Sus scrofa" xref: Reactome:REACT_77906 "Liganded Gs-activating GPCR acts as a GEF for Gs, Danio rerio" xref: Reactome:REACT_78375 "Liganded Gi-activating GPCR acts as a GEF for Gi, Danio rerio" xref: Reactome:REACT_78455 "Gq activation by TP receptor, Xenopus tropicalis" xref: Reactome:REACT_78720 "Liganded Gi-activating GPCR acts as a GEF for Gi, Rattus norvegicus" xref: Reactome:REACT_78874 "Activation of Rap1 by cytosolic GEFs, Mus musculus" xref: Reactome:REACT_78967 "Sar1p Activation And Membrane Binding, Rattus norvegicus" xref: Reactome:REACT_79160 "Activation of Cdc42 by pVav1, Bos taurus" xref: Reactome:REACT_79254 "Gq activation by TP receptor, Canis familiaris" xref: Reactome:REACT_79314 "Activation of Rap1 by membrane-associated GEFs, Bos taurus" xref: Reactome:REACT_79499 "Liganded Gz-activating GPCR acts as a GEF for Gz, Canis familiaris" xref: Reactome:REACT_79750 "Liganded Gz-activating GPCR acts as a GEF for Gz, Xenopus tropicalis" xref: Reactome:REACT_79783 "VAV2 is a GEF for Rho/Rac family kinases, Canis familiaris" xref: Reactome:REACT_79862 "Gq activation by P2Y purinoceptor 1, Taeniopygia guttata" xref: Reactome:REACT_80006 "VAV1 is a GEF for Rho/Rac family kinases, Mus musculus" xref: Reactome:REACT_80507 "Gs activation by prostacyclin receptor, Bos taurus" xref: Reactome:REACT_80641 "Activation of Rap1 by membrane-associated GEFs, Canis familiaris" xref: Reactome:REACT_80694 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Mus musculus" xref: Reactome:REACT_80807 "VAV3 is a GEF for Rho/Rac family kinases, Canis familiaris" xref: Reactome:REACT_81349 "Liganded Gs-activating GPCR acts as a GEF for Gs, Canis familiaris" xref: Reactome:REACT_82067 "Gi activation by P2Y purinoceptor 12, Mus musculus" xref: Reactome:REACT_82396 "Liganded Gi-activating GPCR acts as a GEF for Gi, Xenopus tropicalis" xref: Reactome:REACT_82522 "Regeneration of eEF1A:GTP by eEF1B activity, Plasmodium falciparum" xref: Reactome:REACT_82999 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Canis familiaris" xref: Reactome:REACT_83022 "p115-RhoGEF activation of Rac1, Sus scrofa" xref: Reactome:REACT_83060 "Gs activation by prostacyclin receptor, Mus musculus" xref: Reactome:REACT_83264 "VAV2 is a GEF for Rho/Rac family kinases, Sus scrofa" xref: Reactome:REACT_83428 "Opsins that act as GEFs for G alpha-t, Xenopus tropicalis" xref: Reactome:REACT_83544 "Activation of Rap1 by membrane-associated GEFs, Gallus gallus" xref: Reactome:REACT_83699 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Rattus norvegicus" xref: Reactome:REACT_84621 "Sar1p Activation And Membrane Binding, Arabidopsis thaliana" xref: Reactome:REACT_85103 "VAV3 is a GEF for Rho/Rac family kinases, Bos taurus" xref: Reactome:REACT_85579 "Activation of Cdc42 by pVav1, Sus scrofa" xref: Reactome:REACT_85654 "Gq activation by TP receptor, Danio rerio" xref: Reactome:REACT_85754 "VAV1 is a GEF for Rho/Rac family kinases, Drosophila melanogaster" xref: Reactome:REACT_86122 "Activation of Rap1 by membrane-associated GEFs, Mus musculus" xref: Reactome:REACT_86161 "p115-RhoGEF activation of Rac1, Rattus norvegicus" xref: Reactome:REACT_86316 "p115-RhoGEF activation of Rac1, Mus musculus" xref: Reactome:REACT_86337 "VAV3 is a GEF for Rho/Rac family kinases, Sus scrofa" xref: Reactome:REACT_86600 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Xenopus tropicalis" xref: Reactome:REACT_86605 "G13 activation by TP receptor, Mus musculus" xref: Reactome:REACT_86755 "G13 activation by TP receptor, Xenopus tropicalis" xref: Reactome:REACT_87162 "VAV2 is a GEF for Rho/Rac family kinases, Xenopus tropicalis" xref: Reactome:REACT_87376 "Activation of Rap1 by cytosolic GEFs, Danio rerio" xref: Reactome:REACT_87420 "Activation of Rap1 by cytosolic GEFs, Canis familiaris" xref: Reactome:REACT_87432 "C3G stimulates nucleotide exchange on Rap1, Danio rerio" xref: Reactome:REACT_88322 "Gq activation by TP receptor, Taeniopygia guttata" xref: Reactome:REACT_88390 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Rattus norvegicus" xref: Reactome:REACT_88466 "Liganded Gz-activating GPCR acts as a GEF for Gz, Danio rerio" xref: Reactome:REACT_88628 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Mus musculus" xref: Reactome:REACT_88693 "VAV3 is a GEF for Rho/Rac family kinases, Danio rerio" xref: Reactome:REACT_88712 "Gi activation by P2Y purinoceptor 12, Taeniopygia guttata" xref: Reactome:REACT_88844 "Gi activation by P2Y purinoceptor 12, Sus scrofa" xref: Reactome:REACT_88931 "Gi activation by P2Y purinoceptor 12, Danio rerio" xref: Reactome:REACT_88989 "Opsins that act as GEFs for G alpha-t, Taeniopygia guttata" xref: Reactome:REACT_89041 "Gs activation by prostacyclin receptor, Gallus gallus" xref: Reactome:REACT_89183 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Canis familiaris" xref: Reactome:REACT_89187 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Canis familiaris" xref: Reactome:REACT_89508 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Gallus gallus" xref: Reactome:REACT_89638 "G13 activation by TP receptor, Bos taurus" xref: Reactome:REACT_89812 "Activation of Rap1 by cytosolic GEFs, Taeniopygia guttata" xref: Reactome:REACT_89832 "C3G stimulates nucleotide exchange on Rap1, Canis familiaris" xref: Reactome:REACT_89894 "Activation of Rap1 by cytosolic GEFs, Sus scrofa" xref: Reactome:REACT_90259 "Gs activation by prostacyclin receptor, Canis familiaris" xref: Reactome:REACT_90547 "VAV1 is a GEF for Rho/Rac family kinases, Canis familiaris" xref: Reactome:REACT_90621 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Mus musculus" xref: Reactome:REACT_90735 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Bos taurus" xref: Reactome:REACT_90851 "Gq activation by TP receptor, Bos taurus" xref: Reactome:REACT_90883 "G13 activation by TP receptor, Gallus gallus" xref: Reactome:REACT_90952 "Liganded Gz-activating GPCR acts as a GEF for Gz, Sus scrofa" xref: Reactome:REACT_90957 "VAV3 is a GEF for Rho/Rac family kinases, Gallus gallus" xref: Reactome:REACT_90972 "VAV3 is a GEF for Rho/Rac family kinases, Caenorhabditis elegans" xref: Reactome:REACT_91040 "Gq activation by P2Y purinoceptor 1, Bos taurus" xref: Reactome:REACT_91047 "VAV2 is a GEF for Rho/Rac family kinases, Danio rerio" xref: Reactome:REACT_91400 "Activation of Cdc42 by pVav1, Mus musculus" xref: Reactome:REACT_91460 "Activation of Rap1 by cytosolic GEFs, Caenorhabditis elegans" xref: Reactome:REACT_91485 "Activation of Cdc42 by pVav1, Taeniopygia guttata" xref: Reactome:REACT_91527 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Canis familiaris" xref: Reactome:REACT_91561 "Gq activation by TP receptor, Sus scrofa" xref: Reactome:REACT_92090 "Activation of Rac1 by pVav1, Xenopus tropicalis" xref: Reactome:REACT_92296 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Taeniopygia guttata" xref: Reactome:REACT_92362 "Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex, Xenopus tropicalis" xref: Reactome:REACT_92743 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Bos taurus" xref: Reactome:REACT_92880 "Liganded Gi-activating GPCR acts as a GEF for Gi, Canis familiaris" xref: Reactome:REACT_93072 "Gq activation by P2Y purinoceptor 1, Mus musculus" xref: Reactome:REACT_93077 "Sar1p Activation And Membrane Binding, Mus musculus" xref: Reactome:REACT_93108 "Activation of Rac1 by pVav1, Mus musculus" xref: Reactome:REACT_93352 "G13 activation by TP receptor, Canis familiaris" xref: Reactome:REACT_93442 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Xenopus tropicalis" xref: Reactome:REACT_93643 "C3G stimulates nucleotide exchange on Rap1, Mus musculus" xref: Reactome:REACT_93708 "Gq activation by TP receptor, Rattus norvegicus" xref: Reactome:REACT_93824 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Sus scrofa" xref: Reactome:REACT_93888 "C3G stimulates nucleotide exchange on Rap1, Taeniopygia guttata" xref: Reactome:REACT_93898 "p115-RhoGEF activation of Rac1, Danio rerio" xref: Reactome:REACT_93925 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Gallus gallus" xref: Reactome:REACT_94029 "Activation of Rap1 by cytosolic GEFs, Rattus norvegicus" xref: Reactome:REACT_94065 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Taeniopygia guttata" xref: Reactome:REACT_94237 "VAV3 is a GEF for Rho/Rac family kinases, Mus musculus" xref: Reactome:REACT_94277 "Gi activation by P2Y purinoceptor 12, Xenopus tropicalis" xref: Reactome:REACT_94454 "(Frs2)C3G stimulates nucleotide exchange on Rap1, Taeniopygia guttata" xref: Reactome:REACT_94569 "VAV2 is a GEF for Rho/Rac family kinases, Drosophila melanogaster" xref: Reactome:REACT_94684 "Activation of Rap1 by membrane-associated GEFs, Danio rerio" xref: Reactome:REACT_94737 "Gq activation by P2Y purinoceptor 1, Canis familiaris" xref: Reactome:REACT_94953 "VAV1 is a GEF for Rho/Rac family kinases, Sus scrofa" xref: Reactome:REACT_95254 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Danio rerio" xref: Reactome:REACT_95591 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Rattus norvegicus" xref: Reactome:REACT_96016 "Activation of Gq by Muscarinic Acetylcholine Receptor M3, Taeniopygia guttata" xref: Reactome:REACT_96673 "Activation of Cdc42 by pVav1, Gallus gallus" xref: Reactome:REACT_96836 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, Danio rerio" xref: Reactome:REACT_96942 "Liganded G12/13-activating GPCR acts as a GEF for G12/13, Rattus norvegicus" xref: Reactome:REACT_97040 "Activation of Rap1 by membrane-associated GEFs, Taeniopygia guttata" xref: Reactome:REACT_97508 "Activation of Rap1 by cytosolic GEFs, Gallus gallus" xref: Reactome:REACT_97558 "Regeneration of eEF1A:GTP by eEF1B activity, Danio rerio" xref: Reactome:REACT_97631 "Liganded Gs-activating GPCR acts as a GEF for Gs, Bos taurus" xref: Reactome:REACT_97694 "C3G stimulates nucleotide exchange on Rap1, Xenopus tropicalis" xref: Reactome:REACT_97921 "Activation of Rap1 by membrane-associated GEFs, Xenopus tropicalis" xref: Reactome:REACT_97991 "Gq activation by P2Y purinoceptor 1, Sus scrofa" xref: Reactome:REACT_98174 "VAV2 is a GEF for Rho/Rac family kinases, Mus musculus" xref: Reactome:REACT_98386 "Gs activation by prostacyclin receptor, Xenopus tropicalis" xref: Reactome:REACT_98453 "Gq activation by P2Y purinoceptor 1, Gallus gallus" xref: Reactome:REACT_98827 "VAV2 is a GEF for Rho/Rac family kinases, Rattus norvegicus" xref: Reactome:REACT_99149 "Sar1p Activation And Membrane Binding, Drosophila melanogaster" xref: Reactome:REACT_99303 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11, Danio rerio" is_a: GO:0019899 ! enzyme binding relationship: negatively_regulates GO:0000166 ! nucleotide binding relationship: negatively_regulates GO:0043167 ! ion binding relationship: part_of GO:0008150 ! biological_process relationship: positively_regulates GO:0000166 ! nucleotide binding relationship: positively_regulates GO:0043167 ! ion binding relationship: regulates GO:0000166 ! nucleotide binding relationship: regulates GO:0043167 ! ion binding [Term] id: GO:0005089 name: Rho guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] subset: goslim_chembl synonym: "Rho guanine nucleotide exchange factor" EXACT [] synonym: "RhoGEF" EXACT [] xref: Reactome:REACT_100152 "Activation of Rac1, Xenopus tropicalis" xref: Reactome:REACT_100689 "Activation of Rho by LARG and PDZ-RhoGEF, Sus scrofa" xref: Reactome:REACT_100721 "GEFs activate Rho GTPase:GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_10098 "GEFs activate Rho GTPase:GDP, Homo sapiens" xref: Reactome:REACT_100998 "Activation of Cdc42, Caenorhabditis elegans" xref: Reactome:REACT_101393 "GEFs activate RhoA,B,C, Mus musculus" xref: Reactome:REACT_103139 "Activation of Rho by LARG and PDZ-RhoGEF, Rattus norvegicus" xref: Reactome:REACT_103592 "GEFs activate Rho GTPase:GDP, Caenorhabditis elegans" xref: Reactome:REACT_103724 "Activation of Cdc42, Bos taurus" xref: Reactome:REACT_105214 "Activation of Cdc42, Rattus norvegicus" xref: Reactome:REACT_105608 "GEFs activate RhoA,B,C, Canis familiaris" xref: Reactome:REACT_106134 "GEFs activate RhoA,B,C, Dictyostelium discoideum" xref: Reactome:REACT_108126 "GEFs activate RhoA,B,C, Gallus gallus" xref: Reactome:REACT_108320 "Activation of Rho by LARG and PDZ-RhoGEF, Xenopus tropicalis" xref: Reactome:REACT_108721 "GEFs activate Rho GTPase:GDP, Mus musculus" xref: Reactome:REACT_108759 "Activation of Rho by LARG and PDZ-RhoGEF, Mus musculus" xref: Reactome:REACT_109052 "GEFs activate Rho GTPase:GDP, Danio rerio" xref: Reactome:REACT_109265 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Caenorhabditis elegans" xref: Reactome:REACT_109689 "GEFs activate RhoA,B,C, Rattus norvegicus" xref: Reactome:REACT_112014 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Danio rerio" xref: Reactome:REACT_114452 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Xenopus tropicalis" xref: Reactome:REACT_114487 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Rattus norvegicus" xref: Reactome:REACT_13808 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Homo sapiens" xref: Reactome:REACT_19137 "Activation of Rho by LARG and PDZ-RhoGEF, Homo sapiens" xref: Reactome:REACT_19216 "GEFs activate RhoA,B,C, Homo sapiens" xref: Reactome:REACT_22200 "Activation of Rac1, Homo sapiens" xref: Reactome:REACT_22281 "Activation of Cdc42, Homo sapiens" xref: Reactome:REACT_28825 "Activation of Rho by LARG and PDZ-RhoGEF, Gallus gallus" xref: Reactome:REACT_28967 "GEFs activate Rho GTPase:GDP, Sus scrofa" xref: Reactome:REACT_30773 "GEFs activate Rho GTPase:GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_30791 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Canis familiaris" xref: Reactome:REACT_31433 "GEFs activate RhoA,B,C, Xenopus tropicalis" xref: Reactome:REACT_31965 "Activation of Rac1, Rattus norvegicus" xref: Reactome:REACT_32024 "Activation of Rho by LARG and PDZ-RhoGEF, Bos taurus" xref: Reactome:REACT_32371 "GEFs activate Rho GTPase:GDP, Dictyostelium discoideum" xref: Reactome:REACT_34520 "Activation of Rac1, Mus musculus" xref: Reactome:REACT_77383 "GEFs activate RhoA,B,C, Bos taurus" xref: Reactome:REACT_77389 "GEFs activate RhoA,B,C, Sus scrofa" xref: Reactome:REACT_77531 "GEFs activate Rho GTPase:GDP, Oryza sativa" xref: Reactome:REACT_79833 "GEFs activate Rho GTPase:GDP, Rattus norvegicus" xref: Reactome:REACT_81313 "Activation of Rho by LARG and PDZ-RhoGEF, Danio rerio" xref: Reactome:REACT_82885 "Activation of Rho by LARG and PDZ-RhoGEF, Taeniopygia guttata" xref: Reactome:REACT_82970 "GEFs activate Rho GTPase:GDP, Taeniopygia guttata" xref: Reactome:REACT_84523 "Activation of Cdc42, Mus musculus" xref: Reactome:REACT_85048 "GEFs activate RhoA,B,C, Taeniopygia guttata" xref: Reactome:REACT_86070 "GEFs activate RhoA,B,C, Caenorhabditis elegans" xref: Reactome:REACT_87646 "GEFs activate Rho GTPase:GDP, Xenopus tropicalis" xref: Reactome:REACT_88315 "GEFs activate Rho GTPase:GDP, Bos taurus" xref: Reactome:REACT_91703 "GEFs activate Rho GTPase:GDP, Canis familiaris" xref: Reactome:REACT_92249 "Activation of Rac1, Canis familiaris" xref: Reactome:REACT_92606 "Activation of Cdc42, Danio rerio" xref: Reactome:REACT_92645 "GEFs activate Rho GTPase:GDP, Drosophila melanogaster" xref: Reactome:REACT_93562 "Activation of Cdc42, Xenopus tropicalis" xref: Reactome:REACT_94383 "GEFs activate RhoA,B,C, Danio rerio" xref: Reactome:REACT_94512 "GEFs activate RhoA,B,C, Drosophila melanogaster" xref: Reactome:REACT_95084 "GEFs activate RhoA,B,C, Saccharomyces cerevisiae" xref: Reactome:REACT_95178 "GEFs activate RhoA,B,C, Schizosaccharomyces pombe" xref: Reactome:REACT_95796 "Activation of Rac1, Danio rerio" xref: Reactome:REACT_96171 "Activation of Rac1, Drosophila melanogaster" xref: Reactome:REACT_96181 "Activation of Cdc42, Sus scrofa" xref: Reactome:REACT_96227 "GEFs activate Rho GTPase:GDP, Arabidopsis thaliana" xref: Reactome:REACT_96803 "Activation of Rho by LARG and PDZ-RhoGEF, Canis familiaris" xref: Reactome:REACT_97069 "Activation of Rac1, Bos taurus" xref: Reactome:REACT_97117 "Activation of Cdc42, Drosophila melanogaster" xref: Reactome:REACT_97788 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Bos taurus" xref: Reactome:REACT_98631 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Drosophila melanogaster" xref: Reactome:REACT_98998 "GEFs activate Rho GTPase:GDP, Gallus gallus" xref: Reactome:REACT_99425 "RhoA is activated by nucleotide exchange and inhibits axonal growth, Mus musculus" is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005102 name: signaling receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_agr subset: goslim_chembl subset: goslim_mouse subset: goslim_plant synonym: "receptor binding" BROAD [] synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005109 name: frizzled binding namespace: molecular_function alt_id: GO:0005110 def: "Interacting selectively and non-covalently with a frizzled (fz) receptor." [GOC:ceb, PR:000001315] subset: goslim_chembl synonym: "frizzled ligand" NARROW [] synonym: "frizzled-2 binding" NARROW [] synonym: "frizzled-2 ligand" NARROW [] synonym: "fz binding" EXACT [] synonym: "fz ligand" NARROW [] synonym: "fz2 binding" NARROW [] synonym: "fz2 ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005123 name: death receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015] subset: goslim_chembl synonym: "APO binding" NARROW [GOC:rl] synonym: "death receptor adaptor protein activity" RELATED [] synonym: "death receptor interacting protein activity" RELATED [] synonym: "death receptor ligand" NARROW [] synonym: "death receptor-associated factor activity" RELATED [] synonym: "DR binding" NARROW [GOC:rl] synonym: "EDAR binding" NARROW [GOC:rl] synonym: "FAS binding" NARROW [GOC:rl] synonym: "KILLER binding" NARROW [GOC:rl] synonym: "NGFR binding" NARROW [GOC:rl] synonym: "TNFR1 binding" NARROW [GOC:rl] synonym: "TRAIL binding" NARROW [GOC:rl] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005125 name: cytokine activity namespace: molecular_function def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl synonym: "autocrine activity" RELATED [GOC:rl] synonym: "paracrine activity" RELATED [GOC:rl] is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0005137 name: interleukin-5 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-5 receptor." [GOC:ai] subset: goslim_chembl synonym: "IL-5" NARROW [] synonym: "interleukin-5 receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005138 name: interleukin-6 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-6 receptor." [GOC:ai] subset: goslim_chembl synonym: "IL-6" NARROW [] synonym: "interleukin-6 receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005153 name: interleukin-8 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-8 receptor." [GOC:go_curators] subset: goslim_chembl synonym: "IL-8" NARROW [] synonym: "interleukin-8 receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005154 name: epidermal growth factor receptor binding namespace: molecular_function alt_id: GO:0008185 def: "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] subset: goslim_chembl synonym: "EGF" NARROW [] synonym: "EGF receptor binding" EXACT [] synonym: "EGF receptor ligand" NARROW [] synonym: "EGFR binding" EXACT [] synonym: "epidermal growth factor" NARROW [] synonym: "epidermal growth factor receptor ligand" NARROW [] synonym: "TGF-alpha receptor binding" EXACT [] synonym: "TGFalpha receptor binding" EXACT [] synonym: "transforming growth factor alpha" NARROW [] synonym: "transforming growth factor alpha receptor binding" EXACT [] synonym: "transforming growth factor alpha receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005164 name: tumor necrosis factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai] subset: goslim_chembl synonym: "TNF receptor binding" EXACT [] synonym: "tumor necrosis factor" NARROW [] synonym: "tumor necrosis factor receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005178 name: integrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an integrin." [GOC:ceb] subset: goslim_chembl synonym: "integrin ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0005179 name: hormone activity namespace: molecular_function def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl synonym: "cAMP generating peptide activity" NARROW [] synonym: "glycopeptide hormone" NARROW [] synonym: "lipopeptide hormone" NARROW [] synonym: "peptide hormone" NARROW [] is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0005184 name: neuropeptide hormone activity namespace: molecular_function def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] subset: goslim_chembl synonym: "neurohormone" EXACT [] xref: Wikipedia:Neurohormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0005198 name: structural molecule activity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell." [GOC:mah, GOC:vw] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast is_a: GO:0003674 ! molecular_function [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "carrier" RELATED [] xref: Reactome:REACT_6315 "Virion-associated M2 protein mediated ion infusion, Homo sapiens" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005484 name: SNAP receptor activity namespace: molecular_function alt_id: GO:0005485 alt_id: GO:0005486 def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] subset: goslim_chembl synonym: "Q-SNARE activity" NARROW [] synonym: "R-SNARE activity" NARROW [] synonym: "SNAP-25" NARROW [] synonym: "SNARE" EXACT [] synonym: "t-SNARE activity" NARROW [] synonym: "v-SNARE activity" NARROW [] is_a: GO:0005515 ! protein binding relationship: part_of GO:0061024 ! membrane organization [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] xref: Reactome:REACT_100287 "Formation of the IGF:IGFBP-4 Complex, Canis familiaris" xref: Reactome:REACT_101129 "Formation of the IGF:IGFBP-3:ALS Complex, Rattus norvegicus" xref: Reactome:REACT_102084 "Formation of the IGF:IGFBP-5:ALS Complex, Mus musculus" xref: Reactome:REACT_102457 "An anchoring protein, SARA, recruits SMAD2/3, Canis familiaris" xref: Reactome:REACT_103972 "Type II receptor recruits type I receptor, Xenopus tropicalis" xref: Reactome:REACT_104029 "Formation of the IGF:IGFBP-6 Complex, Bos taurus" xref: Reactome:REACT_104599 "Type II receptor recruits type I receptor, Sus scrofa" xref: Reactome:REACT_105776 "Formation of the IGF:IGFBP-3:ALS Complex, Danio rerio" xref: Reactome:REACT_105895 "Formation of the IGF:IGFBP-4 Complex, Bos taurus" xref: Reactome:REACT_106168 "Formation of the IGF:IGFBP-2 Complex, Bos taurus" xref: Reactome:REACT_106189 "Formation of the IGF:IGFBP-5:ALS Complex, Gallus gallus" xref: Reactome:REACT_107402 "Formation of the IGF:IGFBP-4 Complex, Mus musculus" xref: Reactome:REACT_108283 "Formation of the IGF:IGFBP-4 Complex, Xenopus tropicalis" xref: Reactome:REACT_109392 "Formation of the IGF:IGFBP-3:ALS Complex, Gallus gallus" xref: Reactome:REACT_110419 "Type II receptor recruits type I receptor, Bos taurus" xref: Reactome:REACT_110570 "Formation of the IGF:IGFBP-3:ALS Complex, Sus scrofa" xref: Reactome:REACT_15321 "Formation of the IGF:IGFBP-1 Complex, Homo sapiens" xref: Reactome:REACT_15325 "Formation of the IGF:IGFBP-4 Complex, Homo sapiens" xref: Reactome:REACT_15355 "Formation of the IGF:IGFBP-5:ALS Complex, Homo sapiens" xref: Reactome:REACT_15417 "Formation of the IGF:IGFBP-3:ALS Complex, Homo sapiens" xref: Reactome:REACT_15419 "Formation of the IGF:IGFBP-2 Complex, Homo sapiens" xref: Reactome:REACT_15506 "Formation of the IGF:IGFBP-6 Complex, Homo sapiens" xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens" xref: Reactome:REACT_20509 "Exocytosis of Insulin, Mus musculus" xref: Reactome:REACT_20539 "Traversal of the cortical actin network., Mus musculus" xref: Reactome:REACT_28794 "Formation of the IGF:IGFBP-4 Complex, Sus scrofa" xref: Reactome:REACT_30571 "Formation of the IGF:IGFBP-6 Complex, Danio rerio" xref: Reactome:REACT_30672 "Formation of the IGF:IGFBP-2 Complex, Taeniopygia guttata" xref: Reactome:REACT_31305 "Formation of the IGF:IGFBP-3:ALS Complex, Taeniopygia guttata" xref: Reactome:REACT_31537 "Formation of the IGF:IGFBP-6 Complex, Rattus norvegicus" xref: Reactome:REACT_31641 "Type II receptor recruits type I receptor, Danio rerio" xref: Reactome:REACT_31648 "An anchoring protein, SARA, recruits SMAD2/3, Mus musculus" xref: Reactome:REACT_32973 "Formation of the IGF:IGFBP-1 Complex, Canis familiaris" xref: Reactome:REACT_33135 "An anchoring protein, SARA, recruits SMAD2/3, Rattus norvegicus" xref: Reactome:REACT_34719 "Formation of the IGF:IGFBP-1 Complex, Danio rerio" xref: Reactome:REACT_6923 "An anchoring protein, SARA, recruits SMAD2/3, Homo sapiens" xref: Reactome:REACT_6945 "Type II receptor recruits type I receptor, Homo sapiens" xref: Reactome:REACT_78382 "Formation of the IGF:IGFBP-1 Complex, Mus musculus" xref: Reactome:REACT_78466 "Formation of the IGF:IGFBP-6 Complex, Canis familiaris" xref: Reactome:REACT_79634 "Formation of the IGF:IGFBP-5:ALS Complex, Canis familiaris" xref: Reactome:REACT_80470 "Formation of the IGF:IGFBP-1 Complex, Rattus norvegicus" xref: Reactome:REACT_80778 "Type II receptor recruits type I receptor, Mus musculus" xref: Reactome:REACT_83147 "Type II receptor recruits type I receptor, Rattus norvegicus" xref: Reactome:REACT_83165 "Formation of the IGF:IGFBP-5:ALS Complex, Sus scrofa" xref: Reactome:REACT_83532 "Formation of the IGF:IGFBP-2 Complex, Xenopus tropicalis" xref: Reactome:REACT_85250 "Formation of the IGF:IGFBP-2 Complex, Canis familiaris" xref: Reactome:REACT_85858 "Formation of the IGF:IGFBP-2 Complex, Gallus gallus" xref: Reactome:REACT_85975 "An anchoring protein, SARA, recruits SMAD2/3, Danio rerio" xref: Reactome:REACT_87187 "An anchoring protein, SARA, recruits SMAD2/3, Xenopus tropicalis" xref: Reactome:REACT_87374 "Formation of the IGF:IGFBP-6 Complex, Sus scrofa" xref: Reactome:REACT_87652 "Formation of the IGF:IGFBP-5:ALS Complex, Bos taurus" xref: Reactome:REACT_88068 "Formation of the IGF:IGFBP-3:ALS Complex, Canis familiaris" xref: Reactome:REACT_88138 "Formation of the IGF:IGFBP-5:ALS Complex, Danio rerio" xref: Reactome:REACT_88223 "Formation of the IGF:IGFBP-1 Complex, Sus scrofa" xref: Reactome:REACT_89261 "Formation of the IGF:IGFBP-4 Complex, Taeniopygia guttata" xref: Reactome:REACT_90027 "Formation of the IGF:IGFBP-2 Complex, Rattus norvegicus" xref: Reactome:REACT_90105 "Formation of the IGF:IGFBP-1 Complex, Xenopus tropicalis" xref: Reactome:REACT_90666 "An anchoring protein, SARA, recruits SMAD2/3, Sus scrofa" xref: Reactome:REACT_91560 "Type II receptor recruits type I receptor, Canis familiaris" xref: Reactome:REACT_92029 "Formation of the IGF:IGFBP-4 Complex, Rattus norvegicus" xref: Reactome:REACT_93175 "Formation of the IGF:IGFBP-1 Complex, Gallus gallus" xref: Reactome:REACT_93938 "Formation of the IGF:IGFBP-5:ALS Complex, Rattus norvegicus" xref: Reactome:REACT_94522 "Formation of the IGF:IGFBP-5:ALS Complex, Taeniopygia guttata" xref: Reactome:REACT_94808 "Formation of the IGF:IGFBP-6 Complex, Mus musculus" xref: Reactome:REACT_95241 "Formation of the IGF:IGFBP-3:ALS Complex, Mus musculus" xref: Reactome:REACT_95561 "Formation of the IGF:IGFBP-5:ALS Complex, Xenopus tropicalis" xref: Reactome:REACT_95647 "Formation of the IGF:IGFBP-3:ALS Complex, Bos taurus" xref: Reactome:REACT_96236 "Formation of the IGF:IGFBP-2 Complex, Mus musculus" xref: Reactome:REACT_96264 "Formation of the IGF:IGFBP-2 Complex, Danio rerio" xref: Reactome:REACT_98028 "Formation of the IGF:IGFBP-1 Complex, Taeniopygia guttata" xref: Reactome:REACT_98807 "An anchoring protein, SARA, recruits SMAD2/3, Bos taurus" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005516 name: calmodulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0005520 name: insulin-like growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732] subset: goslim_chembl synonym: "IGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0005537 name: mannose binding namespace: molecular_function def: "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [CHEBI:37684, GOC:jl, ISBN:0192800981] subset: goslim_chembl synonym: "mannose binding lectin" RELATED [] xref: Reactome:REACT_25176 "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi, Homo sapiens" is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0005539 name: glycosaminoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0003674 ! molecular_function [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [GOC:pdt, NIF_Subcellular:sao-1337158144] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao-1337158144 xref: NIF_Subcellular:sao1337158144 [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0005575 ! cellular_component [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cell_wall is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0005622 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005623 ! cell [Term] id: GO:0005623 name: cell namespace: cellular_component def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao1813327414 xref: Wikipedia:Cell_(biology) is_a: GO:0005575 ! cellular_component property_value: IAO:0000589 "cell and encapsulating structures" xsd:string [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005654 name: nucleoplasm namespace: cellular_component def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao661522542 xref: Wikipedia:Nucleoplasm is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043226 ! organelle relationship: part_of GO:0005634 ! nucleus [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043226 ! organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0005773 ! vacuole [Term] id: GO:0005768 name: endosome namespace: cellular_component def: "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant xref: NIF_Subcellular:sao1720343330 xref: Wikipedia:Endosome is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043226 ! organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005777 name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "peroxisomal" RELATED [GOC:curators] synonym: "peroxisome vesicle" BROAD [] xref: NIF_Subcellular:sao499555322 xref: Wikipedia:Peroxisome is_a: GO:0043226 ! organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0043226 ! organelle relationship: part_of GO:0005623 ! cell [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043226 ! organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005811 name: lipid droplet namespace: cellular_component def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_chembl subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid particle" EXACT [] is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005856 ! cytoskeleton [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] subset: goslim_agr subset: goslim_aspergillus subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0032991 ! protein-containing complex is_a: GO:0043226 ! organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoskeleton is_a: GO:0043226 ! organelle relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane relationship: part_of GO:0005623 ! cell [Term] id: GO:0005929 name: cilium namespace: cellular_component alt_id: GO:0072372 def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043226 ! organelle relationship: has_part GO:0016020 ! membrane relationship: has_part GO:0032991 ! protein-containing complex [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process alt_id: GO:0044261 alt_id: GO:0044723 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate metabolic process" NARROW [] synonym: "single-organism carbohydrate metabolic process" RELATED [] xref: Reactome:REACT_102834 "Metabolism of carbohydrates, Mus musculus" xref: Reactome:REACT_103806 "Metabolism of carbohydrates, Mycobacterium tuberculosis" xref: Reactome:REACT_104502 "Metabolism of carbohydrates, Gallus gallus" xref: Reactome:REACT_105321 "Metabolism of carbohydrates, Escherichia coli" xref: Reactome:REACT_106046 "Metabolism of carbohydrates, Drosophila melanogaster" xref: Reactome:REACT_107409 "Metabolism of carbohydrates, Caenorhabditis elegans" xref: Reactome:REACT_115733 "Carbohydrate metabolism, Gallus gallus" xref: Reactome:REACT_28218 "Metabolism of carbohydrates, Xenopus tropicalis" xref: Reactome:REACT_32291 "Metabolism of carbohydrates, Staphylococcus aureus N315" xref: Reactome:REACT_33141 "Metabolism of carbohydrates, Taeniopygia guttata" xref: Reactome:REACT_33953 "Metabolism of carbohydrates, Rattus norvegicus" xref: Reactome:REACT_34800 "Metabolism of carbohydrates, Danio rerio" xref: Reactome:REACT_474 "Metabolism of carbohydrates, Homo sapiens" xref: Reactome:REACT_77669 "Metabolism of carbohydrates, Plasmodium falciparum" xref: Reactome:REACT_81945 "Metabolism of carbohydrates, Schizosaccharomyces pombe" xref: Reactome:REACT_83038 "Metabolism of carbohydrates, Arabidopsis thaliana" xref: Reactome:REACT_83329 "Metabolism of carbohydrates, Saccharomyces cerevisiae" xref: Reactome:REACT_88330 "Metabolism of carbohydrates, Bos taurus" xref: Reactome:REACT_88558 "Metabolism of carbohydrates, Canis familiaris" xref: Reactome:REACT_90099 "Metabolism of carbohydrates, Sus scrofa" xref: Reactome:REACT_96375 "Metabolism of carbohydrates, Dictyostelium discoideum" xref: Reactome:REACT_98394 "Metabolism of carbohydrates, Oryza sativa" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0006397 name: mRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "mRNA maturation" RELATED [] xref: Reactome:REACT_100203 "Processing of Capped Intronless Pre-mRNA, Dictyostelium discoideum" xref: Reactome:REACT_107308 "Processing of Capped Intronless Pre-mRNA, Xenopus tropicalis" xref: Reactome:REACT_109953 "Processing of Capped Intronless Pre-mRNA, Canis familiaris" xref: Reactome:REACT_113864 "Processing of Capped Intronless Pre-mRNA, Saccharomyces cerevisiae" xref: Reactome:REACT_114358 "Processing of Capped Intronless Pre-mRNA, Schizosaccharomyces pombe" xref: Reactome:REACT_115262 "Processing of Capped Intronless Pre-mRNA, Arabidopsis thaliana" xref: Reactome:REACT_1768 "Processing of Capped Intronless Pre-mRNA, Homo sapiens" xref: Reactome:REACT_32742 "Processing of Capped Intronless Pre-mRNA, Bos taurus" xref: Reactome:REACT_33642 "Processing of Capped Intronless Pre-mRNA, Caenorhabditis elegans" xref: Reactome:REACT_82691 "Processing of Capped Intronless Pre-mRNA, Gallus gallus" xref: Reactome:REACT_90366 "Processing of Capped Intronless Pre-mRNA, Drosophila melanogaster" xref: Reactome:REACT_91511 "Processing of Capped Intronless Pre-mRNA, Danio rerio" xref: Reactome:REACT_93186 "Processing of Capped Intronless Pre-mRNA, Sus scrofa" xref: Reactome:REACT_94083 "Processing of Capped Intronless Pre-mRNA, Taeniopygia guttata" xref: Reactome:REACT_96661 "Processing of Capped Intronless Pre-mRNA, Oryza sativa" xref: Reactome:REACT_97412 "Processing of Capped Intronless Pre-mRNA, Rattus norvegicus" xref: Reactome:REACT_97436 "Processing of Capped Intronless Pre-mRNA, Mus musculus" is_a: GO:0034641 ! cellular nitrogen compound metabolic process relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe synonym: "tRNA metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [GOC:curators] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:REACT_100338 "Translation, Sus scrofa" xref: Reactome:REACT_100851 "Translation, Saccharomyces cerevisiae" xref: Reactome:REACT_101045 "Translation, Dictyostelium discoideum" xref: Reactome:REACT_101324 "Translation, Canis familiaris" xref: Reactome:REACT_1014 "Translation, Homo sapiens" xref: Reactome:REACT_103420 "Translation, Plasmodium falciparum" xref: Reactome:REACT_105544 "Translation, Arabidopsis thaliana" xref: Reactome:REACT_29980 "Translation, Bos taurus" xref: Reactome:REACT_33559 "Translation, Rattus norvegicus" xref: Reactome:REACT_77710 "Translation, Drosophila melanogaster" xref: Reactome:REACT_79784 "Translation, Danio rerio" xref: Reactome:REACT_81734 "Translation, Schizosaccharomyces pombe" xref: Reactome:REACT_81833 "Translation, Caenorhabditis elegans" xref: Reactome:REACT_82171 "Translation, Xenopus tropicalis" xref: Reactome:REACT_83429 "Translation, Taeniopygia guttata" xref: Reactome:REACT_83530 "Translation, Gallus gallus" xref: Reactome:REACT_86996 "Translation, Oryza sativa" xref: Reactome:REACT_95535 "Translation, Mus musculus" xref: Reactome:REACT_96394 "Translation, Escherichia coli" xref: Wikipedia:Translation_(genetics) is_a: GO:0009058 ! biosynthetic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process relationship: has_part GO:0008150 ! biological_process [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Reactome:REACT_100411 "Chaperonin-mediated protein folding, Arabidopsis thaliana" xref: Reactome:REACT_104912 "Chaperonin-mediated protein folding, Caenorhabditis elegans" xref: Reactome:REACT_105663 "Chaperonin-mediated protein folding, Rattus norvegicus" xref: Reactome:REACT_106009 "Chaperonin-mediated protein folding, Canis familiaris" xref: Reactome:REACT_106427 "Chaperonin-mediated protein folding, Mus musculus" xref: Reactome:REACT_106894 "Formation of tubulin folding intermediates by CCT/TriC, Canis familiaris" xref: Reactome:REACT_106927 "Chaperonin-mediated protein folding, Drosophila melanogaster" xref: Reactome:REACT_107029 "Formation of tubulin folding intermediates by CCT/TriC, Drosophila melanogaster" xref: Reactome:REACT_108248 "Chaperonin-mediated protein folding, Gallus gallus" xref: Reactome:REACT_109411 "Formation of tubulin folding intermediates by CCT/TriC, Bos taurus" xref: Reactome:REACT_110417 "Formation of tubulin folding intermediates by CCT/TriC, Rattus norvegicus" xref: Reactome:REACT_16956 "Formation of tubulin folding intermediates by CCT/TriC, Homo sapiens" xref: Reactome:REACT_17001 "Formation of tubulin folding intermediates by CCT/TriC, Mus musculus" xref: Reactome:REACT_17004 "Chaperonin-mediated protein folding, Homo sapiens" xref: Reactome:REACT_17056 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Bos taurus" xref: Reactome:REACT_23878 "N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Homo sapiens" xref: Reactome:REACT_30906 "Chaperonin-mediated protein folding, Oryza sativa" xref: Reactome:REACT_32155 "Chaperonin-mediated protein folding, Saccharomyces cerevisiae" xref: Reactome:REACT_32255 "Chaperonin-mediated protein folding, Schizosaccharomyces pombe" xref: Reactome:REACT_33395 "Formation of tubulin folding intermediates by CCT/TriC, Mus musculus" xref: Reactome:REACT_77627 "Chaperonin-mediated protein folding, Plasmodium falciparum" xref: Reactome:REACT_77963 "Formation of tubulin folding intermediates by CCT/TriC, Saccharomyces cerevisiae" xref: Reactome:REACT_78530 "Formation of tubulin folding intermediates by CCT/TriC, Gallus gallus" xref: Reactome:REACT_81155 "Formation of tubulin folding intermediates by CCT/TriC, Caenorhabditis elegans" xref: Reactome:REACT_83906 "Chaperonin-mediated protein folding, Dictyostelium discoideum" xref: Reactome:REACT_85492 "Formation of tubulin folding intermediates by CCT/TriC, Sus scrofa" xref: Reactome:REACT_85496 "Formation of tubulin folding intermediates by CCT/TriC, Plasmodium falciparum" xref: Reactome:REACT_86318 "Formation of tubulin folding intermediates by CCT/TriC, Arabidopsis thaliana" xref: Reactome:REACT_91676 "Formation of tubulin folding intermediates by CCT/TriC, Schizosaccharomyces pombe" xref: Reactome:REACT_92785 "Formation of tubulin folding intermediates by CCT/TriC, Dictyostelium discoideum" xref: Reactome:REACT_92961 "Chaperonin-mediated protein folding, Xenopus tropicalis" xref: Reactome:REACT_92981 "Chaperonin-mediated protein folding, Taeniopygia guttata" xref: Reactome:REACT_94123 "Formation of tubulin folding intermediates by CCT/TriC, Taeniopygia guttata" xref: Reactome:REACT_94443 "Formation of tubulin folding intermediates by CCT/TriC, Danio rerio" xref: Reactome:REACT_94772 "Chaperonin-mediated protein folding, Sus scrofa" xref: Reactome:REACT_96773 "Chaperonin-mediated protein folding, Danio rerio" xref: Reactome:REACT_97016 "Chaperonin-mediated protein folding, Bos taurus" xref: Reactome:REACT_97220 "Formation of tubulin folding intermediates by CCT/TriC, Xenopus tropicalis" xref: Reactome:REACT_98132 "Formation of tubulin folding intermediates by CCT/TriC, Oryza sativa" xref: Wikipedia:Protein_folding is_a: GO:0008150 ! biological_process [Term] id: GO:0006464 name: cellular protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "process resulting in protein modification" RELATED [] synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] synonym: "protein tagging activity" RELATED [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Reactome:REACT_105459 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Gallus gallus" xref: Reactome:REACT_106013 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Canis familiaris" xref: Reactome:REACT_106377 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Mus musculus" xref: Reactome:REACT_107219 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Danio rerio" xref: Reactome:REACT_110326 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Bos taurus" xref: Reactome:REACT_733 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Homo sapiens" xref: Reactome:REACT_84556 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Xenopus tropicalis" xref: Reactome:REACT_92566 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Sus scrofa" xref: Reactome:REACT_95969 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Taeniopygia guttata" xref: Reactome:REACT_98959 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Rattus norvegicus" xref: Wikipedia:Proteolysis is_a: GO:0008152 ! metabolic process [Term] id: GO:0006520 name: cellular amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "amino acid and derivative metabolism" EXACT [GOC:curators] synonym: "amino acid metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid and derivative metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] xref: Reactome:REACT_116093 "Amino acid metabolism, Gallus gallus" is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006605 name: protein targeting namespace: biological_process def: "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] comment: Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "nascent polypeptide association" RELATED [] synonym: "protein sorting along secretory pathway" NARROW [] xref: Wikipedia:Protein_targeting is_a: GO:0006810 ! transport relationship: occurs_in GO:0005622 ! intracellular relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: Reactome:REACT_104930 "Lipid digestion, mobilization, and transport, Drosophila melanogaster" xref: Reactome:REACT_107479 "Lipid digestion, mobilization, and transport, Xenopus tropicalis" xref: Reactome:REACT_108775 "Lipid digestion, mobilization, and transport, Canis familiaris" xref: Reactome:REACT_114669 "Lipid digestion, mobilization, and transport, Staphylococcus aureus N315" xref: Reactome:REACT_115652 "Lipid metabolism, Gallus gallus" xref: Reactome:REACT_28745 "Lipid digestion, mobilization, and transport, Saccharomyces cerevisiae" xref: Reactome:REACT_31395 "Lipid digestion, mobilization, and transport, Sus scrofa" xref: Reactome:REACT_32539 "Lipid digestion, mobilization, and transport, Bos taurus" xref: Reactome:REACT_33836 "Lipid digestion, mobilization, and transport, Rattus norvegicus" xref: Reactome:REACT_602 "Lipid digestion, mobilization, and transport, Homo sapiens" xref: Reactome:REACT_77176 "Lipid digestion, mobilization, and transport, Danio rerio" xref: Reactome:REACT_77191 "Lipid digestion, mobilization, and transport, Arabidopsis thaliana" xref: Reactome:REACT_79244 "Lipid digestion, mobilization, and transport, Plasmodium falciparum" xref: Reactome:REACT_81778 "Lipid digestion, mobilization, and transport, Oryza sativa" xref: Reactome:REACT_82512 "Lipid digestion, mobilization, and transport, Taeniopygia guttata" xref: Reactome:REACT_82723 "Lipid digestion, mobilization, and transport, Escherichia coli" xref: Reactome:REACT_87884 "Lipid digestion, mobilization, and transport, Caenorhabditis elegans" xref: Reactome:REACT_90757 "Lipid digestion, mobilization, and transport, Mus musculus" xref: Reactome:REACT_94607 "Lipid digestion, mobilization, and transport, Mycobacterium tuberculosis" xref: Reactome:REACT_97906 "Lipid digestion, mobilization, and transport, Gallus gallus" xref: Reactome:REACT_98129 "Lipid digestion, mobilization, and transport, Schizosaccharomyces pombe" xref: Reactome:REACT_99706 "Lipid digestion, mobilization, and transport, Dictyostelium discoideum" xref: Wikipedia:Lipid_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Reactome:REACT_27247 "Sulfur compound metabolism, Mycobacterium tuberculosis" xref: Wikipedia:Sulfur_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0006805 name: xenobiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] subset: goslim_chembl subset: goslim_pir synonym: "xenobiotic metabolism" EXACT [] xref: Reactome:REACT_100124 "Conjugation of benzoate with glycine, Mus musculus" xref: Reactome:REACT_100325 "Conjugation of phenylacetate with glutamine, Mus musculus" xref: Reactome:REACT_100603 "Biological oxidations, Arabidopsis thaliana" xref: Reactome:REACT_101131 "Phase 1 - Functionalization of compounds, Dictyostelium discoideum" xref: Reactome:REACT_101207 "Phase II conjugation, Bos taurus" xref: Reactome:REACT_101609 "Conjugation of benzoate with glycine, Staphylococcus aureus N315" xref: Reactome:REACT_102115 "Phase 1 - Functionalization of compounds, Schizosaccharomyces pombe" xref: Reactome:REACT_102424 "Phase 1 - Functionalization of compounds, Danio rerio" xref: Reactome:REACT_102433 "Conjugation of salicylate with glycine, Sus scrofa" xref: Reactome:REACT_102710 "Phase II conjugation, Drosophila melanogaster" xref: Reactome:REACT_102875 "Conjugation of phenylacetate with glutamine, Bos taurus" xref: Reactome:REACT_103896 "Phase 1 - Functionalization of compounds, Saccharomyces cerevisiae" xref: Reactome:REACT_104199 "Phase II conjugation, Staphylococcus aureus N315" xref: Reactome:REACT_104666 "Phase 1 - Functionalization of compounds, Arabidopsis thaliana" xref: Reactome:REACT_104877 "Conjugation of carboxylic acids, Canis familiaris" xref: Reactome:REACT_105707 "Phase 1 - Functionalization of compounds, Canis familiaris" xref: Reactome:REACT_106111 "Phase II conjugation, Schizosaccharomyces pombe" xref: Reactome:REACT_106484 "Conjugation of salicylate with glycine, Danio rerio" xref: Reactome:REACT_106812 "Biological oxidations, Staphylococcus aureus N315" xref: Reactome:REACT_108383 "Phase 1 - Functionalization of compounds, Gallus gallus" xref: Reactome:REACT_110034 "Biological oxidations, Saccharomyces cerevisiae" xref: Reactome:REACT_110188 "Conjugation of phenylacetate with glutamine, Rattus norvegicus" xref: Reactome:REACT_110735 "Conjugation of salicylate with glycine, Canis familiaris" xref: Reactome:REACT_110771 "Phase II conjugation, Saccharomyces cerevisiae" xref: Reactome:REACT_110976 "Biological oxidations, Sus scrofa" xref: Reactome:REACT_112180 "Conjugation of phenylacetate with glutamine, Dictyostelium discoideum" xref: Reactome:REACT_112300 "Amino Acid conjugation, Dictyostelium discoideum" xref: Reactome:REACT_112424 "Conjugation of salicylate with glycine, Dictyostelium discoideum" xref: Reactome:REACT_114132 "Conjugation of benzoate with glycine, Dictyostelium discoideum" xref: Reactome:REACT_115263 "Phase 1 - Functionalization of compounds, Escherichia coli" xref: Reactome:REACT_115368 "Conjugation of carboxylic acids, Dictyostelium discoideum" xref: Reactome:REACT_13433 "Biological oxidations, Homo sapiens" xref: Reactome:REACT_13705 "Phase 1 - Functionalization of compounds, Homo sapiens" xref: Reactome:REACT_30367 "Conjugation of carboxylic acids, Danio rerio" xref: Reactome:REACT_30613 "Amino Acid conjugation, Canis familiaris" xref: Reactome:REACT_31665 "Phase II conjugation, Caenorhabditis elegans" xref: Reactome:REACT_32556 "Biological oxidations, Escherichia coli" xref: Reactome:REACT_32957 "Conjugation of phenylacetate with glutamine, Sus scrofa" xref: Reactome:REACT_33042 "Phase II conjugation, Xenopus tropicalis" xref: Reactome:REACT_33621 "Biological oxidations, Canis familiaris" xref: Reactome:REACT_33687 "Phase 1 - Functionalization of compounds, Drosophila melanogaster" xref: Reactome:REACT_34424 "Biological oxidations, Plasmodium falciparum" xref: Reactome:REACT_43989 "Phase II conjugation, Gallus gallus" xref: Reactome:REACT_6800 "Conjugation of phenylacetate with glutamine, Homo sapiens" xref: Reactome:REACT_6812 "Conjugation of salicylate with glycine, Homo sapiens" xref: Reactome:REACT_6889 "Conjugation of carboxylic acids, Homo sapiens" xref: Reactome:REACT_6933 "Conjugation of benzoate with glycine, Homo sapiens" xref: Reactome:REACT_6959 "Phase II conjugation, Homo sapiens" xref: Reactome:REACT_6971 "Amino Acid conjugation, Homo sapiens" xref: Reactome:REACT_76924 "Biological oxidations, Bos taurus" xref: Reactome:REACT_76938 "Phase II conjugation, Canis familiaris" xref: Reactome:REACT_77460 "Phase II conjugation, Danio rerio" xref: Reactome:REACT_77547 "Phase 1 - Functionalization of compounds, Oryza sativa" xref: Reactome:REACT_77582 "Biological oxidations, Taeniopygia guttata" xref: Reactome:REACT_77645 "Phase 1 - Functionalization of compounds, Mus musculus" xref: Reactome:REACT_78106 "Biological oxidations, Drosophila melanogaster" xref: Reactome:REACT_78563 "Phase 1 - Functionalization of compounds, Sus scrofa" xref: Reactome:REACT_78673 "Amino Acid conjugation, Staphylococcus aureus N315" xref: Reactome:REACT_78750 "Phase 1 - Functionalization of compounds, Taeniopygia guttata" xref: Reactome:REACT_79195 "Conjugation of salicylate with glycine, Mus musculus" xref: Reactome:REACT_80247 "Biological oxidations, Dictyostelium discoideum" xref: Reactome:REACT_80647 "Biological oxidations, Xenopus tropicalis" xref: Reactome:REACT_81143 "Biological oxidations, Mus musculus" xref: Reactome:REACT_81813 "Amino Acid conjugation, Mus musculus" xref: Reactome:REACT_82058 "Phase II conjugation, Escherichia coli" xref: Reactome:REACT_82657 "Biological oxidations, Rattus norvegicus" xref: Reactome:REACT_82846 "Phase II conjugation, Plasmodium falciparum" xref: Reactome:REACT_83594 "Phase II conjugation, Taeniopygia guttata" xref: Reactome:REACT_83912 "Amino Acid conjugation, Bos taurus" xref: Reactome:REACT_83999 "Biological oxidations, Oryza sativa" xref: Reactome:REACT_84336 "Phase 1 - Functionalization of compounds, Caenorhabditis elegans" xref: Reactome:REACT_84559 "Phase 1 - Functionalization of compounds, Xenopus tropicalis" xref: Reactome:REACT_84880 "Conjugation of carboxylic acids, Sus scrofa" xref: Reactome:REACT_86049 "Conjugation of carboxylic acids, Bos taurus" xref: Reactome:REACT_87255 "Phase II conjugation, Oryza sativa" xref: Reactome:REACT_87382 "Phase II conjugation, Mycobacterium tuberculosis" xref: Reactome:REACT_87394 "Amino Acid conjugation, Sus scrofa" xref: Reactome:REACT_87515 "Phase 1 - Functionalization of compounds, Bos taurus" xref: Reactome:REACT_87608 "Phase II conjugation, Mus musculus" xref: Reactome:REACT_88305 "Amino Acid conjugation, Danio rerio" xref: Reactome:REACT_88538 "Conjugation of salicylate with glycine, Rattus norvegicus" xref: Reactome:REACT_89162 "Biological oxidations, Gallus gallus" xref: Reactome:REACT_89167 "Phase II conjugation, Sus scrofa" xref: Reactome:REACT_89372 "Biological oxidations, Danio rerio" xref: Reactome:REACT_89381 "Conjugation of benzoate with glycine, Sus scrofa" xref: Reactome:REACT_89411 "Phase II conjugation, Arabidopsis thaliana" xref: Reactome:REACT_89902 "Biological oxidations, Mycobacterium tuberculosis" xref: Reactome:REACT_89981 "Conjugation of benzoate with glycine, Danio rerio" xref: Reactome:REACT_90526 "Biological oxidations, Caenorhabditis elegans" xref: Reactome:REACT_90693 "Conjugation of phenylacetate with glutamine, Canis familiaris" xref: Reactome:REACT_93150 "Amino Acid conjugation, Rattus norvegicus" xref: Reactome:REACT_93320 "Biological oxidations, Schizosaccharomyces pombe" xref: Reactome:REACT_93377 "Conjugation of carboxylic acids, Rattus norvegicus" xref: Reactome:REACT_94407 "Phase 1 - Functionalization of compounds, Mycobacterium tuberculosis" xref: Reactome:REACT_94419 "Conjugation of carboxylic acids, Staphylococcus aureus N315" xref: Reactome:REACT_95660 "Phase II conjugation, Rattus norvegicus" xref: Reactome:REACT_96794 "Phase II conjugation, Dictyostelium discoideum" xref: Reactome:REACT_96971 "Conjugation of carboxylic acids, Mus musculus" xref: Reactome:REACT_97920 "Conjugation of salicylate with glycine, Bos taurus" xref: Reactome:REACT_98166 "Conjugation of benzoate with glycine, Canis familiaris" xref: Reactome:REACT_98222 "Conjugation of benzoate with glycine, Rattus norvegicus" xref: Reactome:REACT_98651 "Conjugation of benzoate with glycine, Bos taurus" xref: Reactome:REACT_99593 "Conjugation of salicylate with glycine, Staphylococcus aureus N315" xref: Reactome:REACT_99671 "Conjugation of phenylacetate with glutamine, Staphylococcus aureus N315" xref: Reactome:REACT_99818 "Phase 1 - Functionalization of compounds, Rattus norvegicus" xref: Wikipedia:Xenobiotic_metabolism is_a: GO:0008152 ! metabolic process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "single-organism transport" RELATED [] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] is_a: GO:0008150 ! biological_process created_by: janelomax creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process alt_id: GO:0000063 def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0006810 ! transport relationship: occurs_in GO:0005622 ! intracellular relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe xref: Wikipedia:Autophagy_(cellular) is_a: GO:0009056 ! catabolic process relationship: has_part GO:0055085 ! transmembrane transport [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators] is_a: GO:0008150 ! biological_process [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "plasma membrane organisation" EXACT [GOC:curators] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [GOC:curators] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0008150 ! biological_process [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl subset: goslim_generic is_a: GO:0006810 ! transport [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "cell-division cycle" EXACT [] xref: Wikipedia:Cell_cycle is_a: GO:0008150 ! biological_process [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0008150 ! biological_process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process alt_id: GO:0098602 def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0008150 ! biological_process created_by: davidos creation_date: 2014-04-15T15:59:10Z [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023033 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: Reactome:REACT_100624 "EGFR interacts with phospholipase C-gamma, Gallus gallus" xref: Reactome:REACT_102354 "EGFR interacts with phospholipase C-gamma, Canis familiaris" xref: Reactome:REACT_112130 "EGFR interacts with phospholipase C-gamma, Oryza sativa" xref: Reactome:REACT_112549 "EGFR interacts with phospholipase C-gamma, Arabidopsis thaliana" xref: Reactome:REACT_113151 "EGFR interacts with phospholipase C-gamma, Mycobacterium tuberculosis" xref: Reactome:REACT_113601 "EGFR interacts with phospholipase C-gamma, Drosophila melanogaster" xref: Reactome:REACT_113964 "EGFR interacts with phospholipase C-gamma, Bos taurus" xref: Reactome:REACT_114657 "EGFR interacts with phospholipase C-gamma, Dictyostelium discoideum" xref: Reactome:REACT_114690 "EGFR interacts with phospholipase C-gamma, Saccharomyces cerevisiae" xref: Reactome:REACT_114820 "EGFR interacts with phospholipase C-gamma, Sus scrofa" xref: Reactome:REACT_114910 "EGFR interacts with phospholipase C-gamma, Caenorhabditis elegans" xref: Reactome:REACT_115037 "EGFR interacts with phospholipase C-gamma, Plasmodium falciparum" xref: Reactome:REACT_115147 "EGFR interacts with phospholipase C-gamma, Schizosaccharomyces pombe" xref: Reactome:REACT_12478 "EGFR interacts with phospholipase C-gamma, Homo sapiens" xref: Reactome:REACT_31232 "EGFR interacts with phospholipase C-gamma, Rattus norvegicus" xref: Reactome:REACT_78535 "EGFR interacts with phospholipase C-gamma, Xenopus tropicalis" xref: Reactome:REACT_89740 "EGFR interacts with phospholipase C-gamma, Taeniopygia guttata" xref: Reactome:REACT_93680 "EGFR interacts with phospholipase C-gamma, Danio rerio" xref: Reactome:REACT_98872 "EGFR interacts with phospholipase C-gamma, Mus musculus" xref: Wikipedia:Signal_transduction is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: goslim_chembl subset: goslim_plant is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0007565 name: female pregnancy namespace: biological_process def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] subset: goslim_chembl synonym: "carrying of young" RELATED [] synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0008150 ! biological_process relationship: part_of GO:0000003 ! reproduction [Term] id: GO:0007568 name: aging namespace: biological_process alt_id: GO:0016280 def: "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] subset: goslim_chembl subset: goslim_generic synonym: "ageing" EXACT [] xref: Wikipedia:Aging is_a: GO:0008150 ! biological_process [Term] id: GO:0007585 name: respiratory gaseous exchange namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732] subset: goslim_chembl synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] is_a: GO:0008150 ! biological_process [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir xref: Wikipedia:Digestion is_a: GO:0008150 ! biological_process [Term] id: GO:0008009 name: chemokine activity namespace: molecular_function def: "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, http://www.copewithcytokines.de/cope.cgi?key=Cytokines, PMID:12183377] comment: See also the molecular function terms 'cytokine activity ; GO:0005125' and 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl is_a: GO:0005125 ! cytokine activity relationship: part_of GO:0048870 ! cell motility [Term] id: GO:0008022 name: protein C-terminus binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732] subset: goslim_chembl synonym: "C-terminal binding" EXACT [] synonym: "C-terminal end binding" EXACT [GOC:sl] synonym: "carboxy-terminal binding" RELATED [GOC:jsg] synonym: "carboxy-terminus binding" RELATED [GOC:sl] synonym: "carboxyl-terminal binding" RELATED [GOC:jsg] synonym: "carboxyl-terminus binding" RELATED [GOC:sl] synonym: "carboxylate-terminal binding" RELATED [GOC:jsg] synonym: "carboxylate-terminus binding" NARROW [GOC:jsg] synonym: "COOH-terminal binding" NARROW [GOC:jsg] synonym: "COOH-terminus binding" NARROW [GOC:jsg, GOC:sl] is_a: GO:0005515 ! protein binding [Term] id: GO:0008081 name: phosphoric diester hydrolase activity namespace: molecular_function alt_id: GO:0004434 alt_id: GO:0016792 def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] subset: goslim_chembl synonym: "phosphodiesterase" NARROW [] xref: EC:3.1.4 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008083 name: growth factor activity namespace: molecular_function def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0008135 name: translation factor activity, RNA binding namespace: molecular_function def: "Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "translation factor activity, nucleic acid binding" BROAD [GOC:mah] is_a: GO:0003723 ! RNA binding relationship: part_of GO:0006412 ! translation [Term] id: GO:0008146 name: sulfotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] subset: goslim_chembl synonym: "sulphotransferase activity" EXACT [] xref: EC:2.8.2 xref: Reactome:REACT_104339 "lithocholate + PAPS => lithocholate sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_104527 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Bos taurus" xref: Reactome:REACT_113711 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Danio rerio" xref: Reactome:REACT_29304 "lithocholate + PAPS => lithocholate sulfate + PAP, Mus musculus" xref: Reactome:REACT_29933 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Mus musculus" xref: Reactome:REACT_6770 "lithocholate + PAPS => lithocholate sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6814 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6925 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Homo sapiens" xref: Reactome:REACT_77351 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_79428 "lithocholate + PAPS => lithocholate sulfate + PAP, Bos taurus" xref: Reactome:REACT_81801 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Canis familiaris" xref: Reactome:REACT_82640 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Bos taurus" xref: Reactome:REACT_87216 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Mus musculus" xref: Reactome:REACT_89499 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_90640 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_96373 "lithocholate + PAPS => lithocholate sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_98832 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP, Xenopus tropicalis" is_a: GO:0016740 ! transferase activity [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process created_by: janelomax creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] synonym: "multicellular organism metabolic process" NARROW [] synonym: "single-organism metabolic process" RELATED [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process created_by: janelomax creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0008168 name: methyltransferase activity namespace: molecular_function alt_id: GO:0004480 def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "methylase" BROAD [] xref: EC:2.1.1 xref: Reactome:REACT_100745 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Bos taurus" xref: Reactome:REACT_100863 "methylation of Dopamine to form 3-Methoxytyramine, Taeniopygia guttata" xref: Reactome:REACT_100884 "methylation of Dopamine to form 3-Methoxytyramine, Xenopus tropicalis" xref: Reactome:REACT_103958 "methylation of Dopamine to form 3-Methoxytyramine, Rattus norvegicus" xref: Reactome:REACT_104757 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Danio rerio" xref: Reactome:REACT_105478 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Bos taurus" xref: Reactome:REACT_105909 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Xenopus tropicalis" xref: Reactome:REACT_106465 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Sus scrofa" xref: Reactome:REACT_107676 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Schizosaccharomyces pombe" xref: Reactome:REACT_15531 "methylation of Dopamine to form 3-Methoxytyramine, Homo sapiens" xref: Reactome:REACT_15553 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Homo sapiens" xref: Reactome:REACT_2094 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Homo sapiens" xref: Reactome:REACT_29020 "methylation of Dopamine to form 3-Methoxytyramine, Bos taurus" xref: Reactome:REACT_29098 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Canis familiaris" xref: Reactome:REACT_33644 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Mycobacterium tuberculosis" xref: Reactome:REACT_33779 "methylation of Dopamine to form 3-Methoxytyramine, Mycobacterium tuberculosis" xref: Reactome:REACT_73401 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Rattus norvegicus" xref: Reactome:REACT_77286 "methylation of Dopamine to form 3-Methoxytyramine, Canis familiaris" xref: Reactome:REACT_78774 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Mus musculus" xref: Reactome:REACT_79799 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Mus musculus" xref: Reactome:REACT_83214 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Gallus gallus" xref: Reactome:REACT_84525 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Taeniopygia guttata" xref: Reactome:REACT_84974 "methylation of Dopamine to form 3-Methoxytyramine, Sus scrofa" xref: Reactome:REACT_86817 "methylation of Dopamine to form 3-Methoxytyramine, Schizosaccharomyces pombe" xref: Reactome:REACT_86905 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Rattus norvegicus" xref: Reactome:REACT_87169 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Taeniopygia guttata" xref: Reactome:REACT_93379 "methylation of Dopamine to form 3-Methoxytyramine, Gallus gallus" xref: Reactome:REACT_93809 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Xenopus tropicalis" xref: Reactome:REACT_94274 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Canis familiaris" xref: Reactome:REACT_96444 "methylation of Dopamine to form 3-Methoxytyramine, Mus musculus" xref: Reactome:REACT_99316 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Gallus gallus" is_a: GO:0016740 ! transferase activity relationship: part_of GO:0032259 ! methylation [Term] id: GO:0008218 name: bioluminescence namespace: biological_process def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Bioluminescence is_a: GO:0008152 ! metabolic process [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_plant synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4 xref: Reactome:REACT_106748 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Rattus norvegicus" xref: Reactome:REACT_110349 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Mus musculus" xref: Reactome:REACT_13710 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Homo sapiens" xref: Reactome:REACT_19284 "Proteolytic processing of Slit, Homo sapiens" xref: Reactome:REACT_93020 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Bos taurus" xref: Reactome:REACT_99630 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Gallus gallus" is_a: GO:0016787 ! hydrolase activity relationship: part_of GO:0006508 ! proteolysis [Term] id: GO:0008283 name: cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid." [GOC:ai] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast is_a: GO:0003674 ! molecular_function [Term] id: GO:0008474 name: palmitoyl-(protein) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] subset: goslim_chembl synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] synonym: "palmitoyl-protein hydrolase activity" EXACT [] synonym: "palmitoyl-protein thioesterase activity" EXACT [] synonym: "palmitoyl-protein thiolesterase activity" EXACT [] xref: EC:3.1.2.22 xref: MetaCyc:3.1.2.22-RXN xref: Reactome:REACT_106471 "depalmitoylation of eNOS, Rattus norvegicus" xref: Reactome:REACT_106834 "depalmitoylation of eNOS, Bos taurus" xref: Reactome:REACT_12463 "depalmitoylation of eNOS, Homo sapiens" xref: Reactome:REACT_85636 "depalmitoylation of eNOS, Canis familiaris" xref: Reactome:REACT_88738 "depalmitoylation of eNOS, Xenopus tropicalis" xref: Reactome:REACT_95011 "depalmitoylation of eNOS, Mus musculus" xref: Reactome:REACT_97399 "depalmitoylation of eNOS, Sus scrofa" is_a: GO:0016788 ! hydrolase activity, acting on ester bonds relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0008476 name: protein-tyrosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20] synonym: "protein-tyrosine sulphotransferase activity" EXACT [] synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20] xref: EC:2.8.2.20 xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0008565 name: protein transporter activity namespace: molecular_function alt_id: GO:0015463 def: "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "enzyme transporter activity" NARROW [] synonym: "holin" RELATED [] synonym: "protein carrier activity" EXACT [] synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "secretin" RELATED [] is_a: GO:0005215 ! transporter activity relationship: part_of GO:0006810 ! transport [Term] id: GO:0008963 name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: goslim_chembl synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13] synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13] xref: EC:2.7.8.13 xref: MetaCyc:RXN-8975 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0008970 name: phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] subset: goslim_chembl synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [] xref: EC:3.1.1.32 xref: MetaCyc:PHOSPHOLIPASE-A1-RXN is_a: GO:0004620 ! phospholipase activity [Term] id: GO:0009056 name: catabolic process namespace: biological_process alt_id: GO:0044243 alt_id: GO:0044712 def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "breakdown" EXACT [] synonym: "catabolism" EXACT [] synonym: "degradation" EXACT [] synonym: "multicellular organismal catabolic process" NARROW [] synonym: "single-organism catabolic process" RELATED [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process created_by: janelomax creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0009405 name: pathogenesis namespace: biological_process def: "The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism." [GOC:go_curators] comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics synonym: "virulence" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant xref: Wikipedia:Plastid is_a: GO:0043226 ! organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0009579 name: thylakoid namespace: cellular_component def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732] comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005622 ! intracellular [Term] id: GO:0009636 name: response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] subset: goslim_chembl synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0009690 name: cytokinin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] subset: goslim_chembl synonym: "cytokinin metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0009820 name: alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] subset: goslim_chembl synonym: "alkaloid metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0010951 name: negative regulation of endopeptidase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] subset: goslim_chembl is_a: GO:0050790 ! regulation of catalytic activity relationship: negatively_regulates GO:0008233 ! peptidase activity relationship: regulates GO:0008233 ! peptidase activity created_by: tanyaberardini creation_date: 2009-04-27T11:47:01Z [Term] id: GO:0015976 name: carbon utilization namespace: biological_process alt_id: GO:0015978 def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: goslim_chembl subset: goslim_pir synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah] synonym: "heterotrophy" EXACT [] xref: Wikipedia:Heterotroph is_a: GO:0008150 ! biological_process relationship: has_part GO:0006810 ! transport relationship: has_part GO:0008152 ! metabolic process [Term] id: GO:0015979 name: photosynthesis namespace: biological_process def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant xref: Wikipedia:Photosynthesis is_a: GO:0008152 ! metabolic process [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Biological_membrane is_a: GO:0005575 ! cellular_component [Term] id: GO:0016021 name: integral component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] subset: goslim_chembl synonym: "integral to membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] xref: Wikipedia:Transmembrane_protein is_a: GO:0005575 ! cellular_component relationship: part_of GO:0016020 ! membrane [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport [Term] id: GO:0016290 name: palmitoyl-CoA hydrolase activity namespace: molecular_function alt_id: GO:0016293 def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2] subset: goslim_chembl synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2] synonym: "long-chain fatty-acyl-CoA hydrolase activity" BROAD [] synonym: "palmitoyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl-CoA deacylase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2] synonym: "palmityl-CoA deacylase activity" EXACT [EC:3.1.2.2] xref: EC:3.1.2.2 xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN xref: MetaCyc:PWY-5148 xref: RHEA:16645 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0016298 name: lipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] subset: goslim_aspergillus subset: goslim_chembl xref: EC:3.1.1 xref: Reactome:REACT_100499 "cholesterol ester + H2O -> cholesterol + fatty acid, Mus musculus" xref: Reactome:REACT_112065 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Danio rerio" xref: Reactome:REACT_114396 "cholesterol ester + H2O -> cholesterol + fatty acid, Danio rerio" xref: Reactome:REACT_1867 "cholesterol ester + H2O -> cholesterol + fatty acid, Rattus norvegicus" xref: Reactome:REACT_413 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Rattus norvegicus" xref: Reactome:REACT_731 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Homo sapiens" xref: Reactome:REACT_764 "cholesterol ester + H2O -> cholesterol + fatty acid, Homo sapiens" xref: Reactome:REACT_81298 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Caenorhabditis elegans" xref: Reactome:REACT_85531 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Mus musculus" xref: Reactome:REACT_87294 "cholesterol ester + H2O -> cholesterol + fatty acid, Canis familiaris" xref: Reactome:REACT_90239 "cholesterol ester + H2O -> cholesterol + fatty acid, Bos taurus" xref: Reactome:REACT_91590 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Bos taurus" xref: Reactome:REACT_94613 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Canis familiaris" xref: Reactome:REACT_95662 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid, Xenopus tropicalis" xref: Reactome:REACT_96515 "cholesterol ester + H2O -> cholesterol + fatty acid, Xenopus tropicalis" xref: Reactome:REACT_97125 "cholesterol ester + H2O -> cholesterol + fatty acid, Caenorhabditis elegans" is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: Reactome:REACT_100073 "Activation of S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_100078 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_100159 "Inactivation of Myt1 kinase, Mus musculus" xref: Reactome:REACT_100260 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Taeniopygia guttata" xref: Reactome:REACT_100298 "Phosphorylation of L1 by CK-II, Rattus norvegicus" xref: Reactome:REACT_100305 "Regulation of NUDC by phosphorylation, Caenorhabditis elegans" xref: Reactome:REACT_100311 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Canis familiaris" xref: Reactome:REACT_100390 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Canis familiaris" xref: Reactome:REACT_100465 "Phosphorylation and inactivation of eEF2K by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_100495 "Cdc6 protein is phosphorylated by CDK, Xenopus tropicalis" xref: Reactome:REACT_100519 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Bos taurus" xref: Reactome:REACT_100636 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Canis familiaris" xref: Reactome:REACT_100637 "Phosphorylation of the Scc1:Cohesion Complex, Mus musculus" xref: Reactome:REACT_101024 "Phosphorylation and inactivation of eEF2K by activated S6K1, Bos taurus" xref: Reactome:REACT_101170 "Phosphorylation of APC component of the destruction complex, Drosophila melanogaster" xref: Reactome:REACT_101303 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Mus musculus" xref: Reactome:REACT_101431 "Mcm2-7 is phosphorylated by DDK, Danio rerio" xref: Reactome:REACT_101543 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Canis familiaris" xref: Reactome:REACT_101596 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Canis familiaris" xref: Reactome:REACT_101638 "Phosphorylation and activation of CHK2 by ATM, Bos taurus" xref: Reactome:REACT_101667 "Down Regulation of Emi1 through Phosphorylation of Emi1, Bos taurus" xref: Reactome:REACT_101841 "Phosphorylation of Cdc25C at Ser216, Rattus norvegicus" xref: Reactome:REACT_101862 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Xenopus tropicalis" xref: Reactome:REACT_101914 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_102090 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_102093 "Phosphorylation and activation of eIF4G by activated S6K1, Danio rerio" xref: Reactome:REACT_102154 "Autophosphorylation of PAK-2p34 in the activation loop, Schizosaccharomyces pombe" xref: Reactome:REACT_102322 "RAF1 phosphorylates MEK2, Danio rerio" xref: Reactome:REACT_102330 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Xenopus tropicalis" xref: Reactome:REACT_102380 "Regulation of KIF23 (MKLP1) by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_102475 "Inactivation of Myt1 kinase, Rattus norvegicus" xref: Reactome:REACT_102499 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_102552 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Canis familiaris" xref: Reactome:REACT_102607 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Drosophila melanogaster" xref: Reactome:REACT_102711 "Phosphorylation of L1 by CK-II, Caenorhabditis elegans" xref: Reactome:REACT_102729 "RAF1 phosphorylates MEK1, Xenopus tropicalis" xref: Reactome:REACT_102817 "Phosphorylation of L1 by ERK, Mus musculus" xref: Reactome:REACT_102887 "Mcm2-7 is phosphorylated by DDK, Rattus norvegicus" xref: Reactome:REACT_102908 "Phosphorylation of the Scc1:Cohesion Complex, Rattus norvegicus" xref: Reactome:REACT_102915 "Activation of S6K1, Arabidopsis thaliana" xref: Reactome:REACT_103060 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Arabidopsis thaliana" xref: Reactome:REACT_103291 "Phosphorylation of complexed TSC2 by PKB, Drosophila melanogaster" xref: Reactome:REACT_103327 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Rattus norvegicus" xref: Reactome:REACT_103359 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Danio rerio" xref: Reactome:REACT_103468 "Activation of Cdc25C, Drosophila melanogaster" xref: Reactome:REACT_103691 "Phosphorylation of COP1 at Ser-387 by ATM, Xenopus tropicalis" xref: Reactome:REACT_103727 "Phosphorylation of NBS1 by ATM, Drosophila melanogaster" xref: Reactome:REACT_103804 "Phosphorylation of AKT2 by PDK1, Canis familiaris" xref: Reactome:REACT_103989 "Phosphorylation of NBS1 by ATM, Danio rerio" xref: Reactome:REACT_104022 "Phosphorylation of p53 at ser-15 by ATM kinase, Xenopus tropicalis" xref: Reactome:REACT_104044 "Phosphorylation and activation of Chk1 by ATM, Sus scrofa" xref: Reactome:REACT_104109 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Danio rerio" xref: Reactome:REACT_104209 "Activation of S6K1, Caenorhabditis elegans" xref: Reactome:REACT_104323 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_104386 "Phosphorylation and activation of eIF4B by activated S6K1, Bos taurus" xref: Reactome:REACT_104523 "Inactivation of Wee1 kinase, Bos taurus" xref: Reactome:REACT_104644 "Regulation of KIF20A (MKL2) by phosphorylation, Bos taurus" xref: Reactome:REACT_104687 "Phosphorylation of L1 by CK-II, Canis familiaris" xref: Reactome:REACT_104730 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Schizosaccharomyces pombe" xref: Reactome:REACT_104822 "Phosphorylation of COP1 at Ser-387 by ATM, Rattus norvegicus" xref: Reactome:REACT_104837 "SOS phosphorylation and dissociation (SHC), Mus musculus" xref: Reactome:REACT_104878 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Xenopus tropicalis" xref: Reactome:REACT_105254 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Danio rerio" xref: Reactome:REACT_105274 "Regulation of KIF20A (MKL2) by phosphorylation, Danio rerio" xref: Reactome:REACT_105345 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_105373 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Gallus gallus" xref: Reactome:REACT_105503 "Phosphorylation of L1 by ERK, Bos taurus" xref: Reactome:REACT_105561 "Phosphorylation of complexed TSC2 by PKB, Xenopus tropicalis" xref: Reactome:REACT_105569 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_105589 "Phosphorylation of p53 at ser-15 by ATM kinase, Canis familiaris" xref: Reactome:REACT_105664 "Akt1 phosphorylates BAD protein, Rattus norvegicus" xref: Reactome:REACT_105700 "Phosphorylation of PDE3B, Rattus norvegicus" xref: Reactome:REACT_105971 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Xenopus tropicalis" xref: Reactome:REACT_105976 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Xenopus tropicalis" xref: Reactome:REACT_106075 "Akt1 phosphorylates BAD protein, Canis familiaris" xref: Reactome:REACT_106144 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Xenopus tropicalis" xref: Reactome:REACT_106159 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_106186 "Phosphorylation of TSC2 by PKB, Drosophila melanogaster" xref: Reactome:REACT_106225 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Canis familiaris" xref: Reactome:REACT_1063 "Phosphorylation of Wee1 kinase by Chk1, Schizosaccharomyces pombe" xref: Reactome:REACT_106324 "Activation of Cdc25C, Mus musculus" xref: Reactome:REACT_106383 "Phosphorylation of L1 by ERK, Xenopus tropicalis" xref: Reactome:REACT_106411 "Phosphorylation and inactivation of eEF2K by activated S6K1, Gallus gallus" xref: Reactome:REACT_106420 "Regulation of KIF23 (MKLP1) by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_106500 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Drosophila melanogaster" xref: Reactome:REACT_106505 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Rattus norvegicus" xref: Reactome:REACT_106514 "Phosphorylation of NBS1 by ATM, Mus musculus" xref: Reactome:REACT_106567 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Mus musculus" xref: Reactome:REACT_106599 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Xenopus tropicalis" xref: Reactome:REACT_106681 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Rattus norvegicus" xref: Reactome:REACT_106722 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_106738 "SOS phosphorylation and dissociation (IRS, Crk), Canis familiaris" xref: Reactome:REACT_106897 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Danio rerio" xref: Reactome:REACT_107009 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Arabidopsis thaliana" xref: Reactome:REACT_107055 "Phosphorylation of Cdc25C at Ser216, Bos taurus" xref: Reactome:REACT_107102 "SOS phosphorylation and dissociation (IRS, Crk), Danio rerio" xref: Reactome:REACT_107243 "Phosphorylation of APC component of the destruction complex, Mus musculus" xref: Reactome:REACT_107247 "Phosphorylation of TSC2 by PKB, Mus musculus" xref: Reactome:REACT_107310 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Danio rerio" xref: Reactome:REACT_107424 "Inactivation of Myt1 kinase, Canis familiaris" xref: Reactome:REACT_107623 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Mus musculus" xref: Reactome:REACT_107685 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Sus scrofa" xref: Reactome:REACT_107732 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Danio rerio" xref: Reactome:REACT_107736 "Phosphorylation of Cdc25C at Ser216, Sus scrofa" xref: Reactome:REACT_107787 "Phosphorylation and activation of CHK2 by ATM, Drosophila melanogaster" xref: Reactome:REACT_107849 "Phosphorylation of DLC2 by MAPK-8, Bos taurus" xref: Reactome:REACT_107854 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Canis familiaris" xref: Reactome:REACT_108002 "Plk1-mediated phosphorylation of Nlp, Bos taurus" xref: Reactome:REACT_108096 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Rattus norvegicus" xref: Reactome:REACT_108132 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Gallus gallus" xref: Reactome:REACT_108362 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Mus musculus" xref: Reactome:REACT_108394 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Danio rerio" xref: Reactome:REACT_108520 "Phosphorylation and activation of Chk1 by ATM, Danio rerio" xref: Reactome:REACT_108578 "Inactivation of Myt1 kinase, Xenopus tropicalis" xref: Reactome:REACT_108776 "Free APC/C phosphorylated by Plk1, Taeniopygia guttata" xref: Reactome:REACT_108840 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Canis familiaris" xref: Reactome:REACT_108871 "Free APC/C phosphorylated by Plk1, Mus musculus" xref: Reactome:REACT_108971 "Phosphorylation of Cyclin B1 in the CRS domain, Xenopus tropicalis" xref: Reactome:REACT_108985 "Phosphorylation of cPLA2 by ERK-2, Gallus gallus" xref: Reactome:REACT_109045 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Danio rerio" xref: Reactome:REACT_109065 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Taeniopygia guttata" xref: Reactome:REACT_109117 "Phosphorylation of 4E-BP1 by activated mTORC1, Dictyostelium discoideum" xref: Reactome:REACT_109197 "SOS phosphorylation and dissociation (IRS), Mus musculus" xref: Reactome:REACT_109244 "Inactivation of Myt1 kinase, Schizosaccharomyces pombe" xref: Reactome:REACT_109260 "Free APC/C phosphorylated by Plk1, Xenopus tropicalis" xref: Reactome:REACT_109264 "SOS phosphorylation and dissociation (IRS), Canis familiaris" xref: Reactome:REACT_109331 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Drosophila melanogaster" xref: Reactome:REACT_109367 "Phosphorylation of APC component of the destruction complex, Gallus gallus" xref: Reactome:REACT_109549 "Regulation of KIF20A (MKL2) by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_109641 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Sus scrofa" xref: Reactome:REACT_109769 "Free APC/C phosphorylated by Plk1, Gallus gallus" xref: Reactome:REACT_109799 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Mus musculus" xref: Reactome:REACT_110175 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Mus musculus" xref: Reactome:REACT_110254 "Phosphorylation of APC component of the destruction complex, Rattus norvegicus" xref: Reactome:REACT_110296 "Phosphorylation and activation of Chk1 by ATM, Schizosaccharomyces pombe" xref: Reactome:REACT_110351 "Phosphorylation and inactivation of eEF2K by activated S6K1, Canis familiaris" xref: Reactome:REACT_110382 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Oryza sativa" xref: Reactome:REACT_110530 "Down Regulation of Emi1 through Phosphorylation of Emi1, Mus musculus" xref: Reactome:REACT_110583 "Phosphorylation of DLC2 by MAPK-8, Mus musculus" xref: Reactome:REACT_110643 "Mcm2-7 is phosphorylated by DDK, Xenopus tropicalis" xref: Reactome:REACT_110679 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Danio rerio" xref: Reactome:REACT_110774 "Inactivation of Myt1 kinase, Drosophila melanogaster" xref: Reactome:REACT_110775 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Rattus norvegicus" xref: Reactome:REACT_110947 "Regulation of KIF23 (MKLP1) by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_110995 "Phosphorylation and activation of eIF4G by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_111124 "FGFR associated PI3K phosphorylates PIP2 to PIP3, Homo sapiens" xref: Reactome:REACT_111171 "FGFR-associated PI3K phosphorylates PIP2 to PIP3, Homo sapiens" xref: Reactome:REACT_1116 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Homo sapiens" xref: Reactome:REACT_111930 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Caenorhabditis elegans" xref: Reactome:REACT_1120 "Regulation of KIF20A (MKL2) by phosphorylation, Homo sapiens" xref: Reactome:REACT_112075 "Mcm2-7 is phosphorylated by DDK, Drosophila melanogaster" xref: Reactome:REACT_112101 "Phosphorylation of L1 by CK-II, Xenopus tropicalis" xref: Reactome:REACT_112156 "Phosphorylation of AKT2 by PDK1, Saccharomyces cerevisiae" xref: Reactome:REACT_112214 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Schizosaccharomyces pombe" xref: Reactome:REACT_112270 "Akt1 phosphorylates BAD protein, Xenopus tropicalis" xref: Reactome:REACT_112298 "Autophosphorylation of DNA-PKcs, Dictyostelium discoideum" xref: Reactome:REACT_112324 "Phosphorylation and activation of eIF4G by activated S6K1, Oryza sativa" xref: Reactome:REACT_112360 "Regulation of KIF23 (MKLP1) by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_112413 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Saccharomyces cerevisiae" xref: Reactome:REACT_112480 "Inactivation of Wee1 kinase, Dictyostelium discoideum" xref: Reactome:REACT_112545 "Phosphorylation and activation of eIF4G by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_112633 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Saccharomyces cerevisiae" xref: Reactome:REACT_112709 "Phosphorylation of L1 by ERK, Saccharomyces cerevisiae" xref: Reactome:REACT_112722 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Drosophila melanogaster" xref: Reactome:REACT_112790 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Caenorhabditis elegans" xref: Reactome:REACT_112846 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Saccharomyces cerevisiae" xref: Reactome:REACT_112892 "Phosphorylation of BRCA1 at multiple sites by ATM, Oryza sativa" xref: Reactome:REACT_112948 "Autophosphorylation of DNA-PKcs, Rattus norvegicus" xref: Reactome:REACT_113022 "Phosphorylation of Cyclin B1 in the CRS domain, Schizosaccharomyces pombe" xref: Reactome:REACT_113051 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Arabidopsis thaliana" xref: Reactome:REACT_113121 "Phosphorylation and activation of eIF4B by activated S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_113227 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Saccharomyces cerevisiae" xref: Reactome:REACT_113244 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_113269 "Activation of S6K1, Saccharomyces cerevisiae" xref: Reactome:REACT_113435 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Oryza sativa" xref: Reactome:REACT_113527 "Autophosphorylation of DNA-PKcs, Bos taurus" xref: Reactome:REACT_113569 "Activation of Cdc25C, Saccharomyces cerevisiae" xref: Reactome:REACT_113811 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Bos taurus" xref: Reactome:REACT_113820 "Phosphorylation of Cyclin B1 in the CRS domain, Saccharomyces cerevisiae" xref: Reactome:REACT_113894 "PIP2 conversion to PIP3, Caenorhabditis elegans" xref: Reactome:REACT_113929 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Caenorhabditis elegans" xref: Reactome:REACT_113990 "Activation of Cdc25C, Schizosaccharomyces pombe" xref: Reactome:REACT_114160 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Saccharomyces cerevisiae" xref: Reactome:REACT_114198 "Phosphorylation of the Scc1:Cohesion Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_114207 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Schizosaccharomyces pombe" xref: Reactome:REACT_114227 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Schizosaccharomyces pombe" xref: Reactome:REACT_114233 "Autophosphorylation of DNA-PKcs, Sus scrofa" xref: Reactome:REACT_114255 "Autophosphorylation of DNA-PKcs, Mus musculus" xref: Reactome:REACT_114268 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Schizosaccharomyces pombe" xref: Reactome:REACT_114280 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Saccharomyces cerevisiae" xref: Reactome:REACT_114319 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Caenorhabditis elegans" xref: Reactome:REACT_114323 "Activation of Cdc25C, Caenorhabditis elegans" xref: Reactome:REACT_114395 "Phosphorylation of DLC1 by MAPK 8, Xenopus tropicalis" xref: Reactome:REACT_114434 "Autophosphorylation of DNA-PKcs, Taeniopygia guttata" xref: Reactome:REACT_114461 "Phosphorylation of AKT2 by PDK1, Schizosaccharomyces pombe" xref: Reactome:REACT_114522 "Phosphorylation of BRCA1 at multiple sites by ATM, Arabidopsis thaliana" xref: Reactome:REACT_114553 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Saccharomyces cerevisiae" xref: Reactome:REACT_114599 "Phosphorylation of TSC2 by PKB, Schizosaccharomyces pombe" xref: Reactome:REACT_114624 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Drosophila melanogaster" xref: Reactome:REACT_114771 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Canis familiaris" xref: Reactome:REACT_114906 "Phosphorylation and activation of eIF4G by activated S6K1, Arabidopsis thaliana" xref: Reactome:REACT_114984 "Autophosphorylation of DNA-PKcs, Xenopus tropicalis" xref: Reactome:REACT_115006 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Caenorhabditis elegans" xref: Reactome:REACT_115135 "Phosphorylation and activation of eIF4G by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_115168 "Autophosphorylation of DNA-PKcs, Gallus gallus" xref: Reactome:REACT_115199 "Autophosphorylation of DNA-PKcs, Canis familiaris" xref: Reactome:REACT_115358 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Drosophila melanogaster" xref: Reactome:REACT_115384 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Schizosaccharomyces pombe" xref: Reactome:REACT_115440 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Danio rerio" xref: Reactome:REACT_115472 "Phosphorylation of the SA2 Cohesin Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_115475 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Schizosaccharomyces pombe" xref: Reactome:REACT_115521 "Autophosphorylation of DNA-PKcs, Danio rerio" xref: Reactome:REACT_115527 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Schizosaccharomyces pombe" xref: Reactome:REACT_115747 "Phosphorylation of H2AX at S139 by ATM at the site of DSB, Gallus gallus" xref: Reactome:REACT_116149 "Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members, Gallus gallus" xref: Reactome:REACT_118137 "Phosphorylation of the Scc1:Cohesion Complex, Taeniopygia guttata" xref: Reactome:REACT_118229 "Phosphorylation of the SA2 Cohesin Complex, Taeniopygia guttata" xref: Reactome:REACT_118284 "Phosphorylation of the Scc1:Cohesion Complex, Saccharomyces cerevisiae" xref: Reactome:REACT_118307 "Phosphorylation of the SA2 Cohesin Complex, Gallus gallus" xref: Reactome:REACT_118367 "Phosphorylation of the Scc1:Cohesion Complex, Gallus gallus" xref: Reactome:REACT_118462 "Phosphorylation of the SA2 Cohesin Complex, Saccharomyces cerevisiae" xref: Reactome:REACT_1185 "Phosphorylation (Ser5) of RNA pol II CTD, Homo sapiens" xref: Reactome:REACT_1279 "Cdc6 protein is phosphorylated by CDK, Homo sapiens" xref: Reactome:REACT_128 "Phosphorylation of Cdc25C at Ser216, Homo sapiens" xref: Reactome:REACT_132 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Homo sapiens" xref: Reactome:REACT_1326 "Regulation of NUDC by phosphorylation, Homo sapiens" xref: Reactome:REACT_13431 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Homo sapiens" xref: Reactome:REACT_13581 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Oryctolagus cuniculus" xref: Reactome:REACT_1362 "Phosphorylation of the Scc1:Cohesion Complex, Homo sapiens" xref: Reactome:REACT_13817 "Autophosphorylation of PAK-2p34, Oryctolagus cuniculus" xref: Reactome:REACT_1382 "Phosphorylation of PDE3B by AKT-1, Mus musculus" xref: Reactome:REACT_13820 "Autophosphorylation of PAK-2p34 in the activation loop, Homo sapiens" xref: Reactome:REACT_1420 "SOS phosphorylation and dissociation (SHC), Homo sapiens" xref: Reactome:REACT_1481 "Phosphorylation of the SA2 Cohesin Complex, Homo sapiens" xref: Reactome:REACT_1517 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Homo sapiens" xref: Reactome:REACT_15386 "Plk1-mediated phosphorylation of Nlp, Homo sapiens" xref: Reactome:REACT_1603 "Phosphorylation and activation of CHK2 by ATM, Homo sapiens" xref: Reactome:REACT_1657 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Homo sapiens" xref: Reactome:REACT_1680 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Homo sapiens" xref: Reactome:REACT_169 "SOS phosphorylation and dissociation (IRS), Homo sapiens" xref: Reactome:REACT_1727 "RAF1 phosphorylates MEK2, Homo sapiens" xref: Reactome:REACT_1756 "Phosphorylation of p53 at ser-15 by ATM kinase, Homo sapiens" xref: Reactome:REACT_1782 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Homo sapiens" xref: Reactome:REACT_1808 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Homo sapiens" xref: Reactome:REACT_1878 "Phosphorylation of PDE3B, Homo sapiens" xref: Reactome:REACT_188 "Akt1 phosphorylates BAD protein, Homo sapiens" xref: Reactome:REACT_1888 "Phosphorylation of DLC1 by MAPK 8, Homo sapiens" xref: Reactome:REACT_1930 "Regulation of KIF23 (MKLP1) by phosphorylation, Homo sapiens" xref: Reactome:REACT_19312 "Phosphorylation of PD-1, Homo sapiens" xref: Reactome:REACT_1944 "Inactivation of Wee1 kinase, Homo sapiens" xref: Reactome:REACT_1981 "Phosphorylation of DLC2 by MAPK-8, Homo sapiens" xref: Reactome:REACT_2009 "Phosphorylation of NBS1 by ATM, Homo sapiens" xref: Reactome:REACT_203 "Raf1 phosphorylates MEK1, Rattus norvegicus" xref: Reactome:REACT_20503 "Phosphorylation of CREB by ribosomal protein S6 kinase, Homo sapiens" xref: Reactome:REACT_20543 "Phosphorylation of COP1 at Ser-387 by ATM, Homo sapiens" xref: Reactome:REACT_20562 "Phosphorylation by MAPK/ERK, Homo sapiens" xref: Reactome:REACT_20578 "Raf activation, Homo sapiens" xref: Reactome:REACT_20583 "Phosphorylation of CREB by PKA, Homo sapiens" xref: Reactome:REACT_20631 "Activation of MAPK, Homo sapiens" xref: Reactome:REACT_20640 "Phophorylation by PDK1, Homo sapiens" xref: Reactome:REACT_2066 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Homo sapiens" xref: Reactome:REACT_2111 "Orc1 is phosphorylated by cyclin A/CDK2, Homo sapiens" xref: Reactome:REACT_2119 "Activation of Cdc25C, Homo sapiens" xref: Reactome:REACT_215 "Autophosphorylation of DNA-PKcs, Homo sapiens" xref: Reactome:REACT_22099 "Phosphorylation of L1 by ERK, Homo sapiens" xref: Reactome:REACT_22378 "Phosphorylation of L1 by CK-II, Homo sapiens" xref: Reactome:REACT_23976 "Raf1 phosphorylates MEK2, Rattus norvegicus" xref: Reactome:REACT_23990 "Phosphorylation of cPLA2 by ERK-2, Homo sapiens" xref: Reactome:REACT_244 "PIP2 conversion to PIP3, Homo sapiens" xref: Reactome:REACT_26 "SOS phosphorylation and dissociation (IRS, Crk), Homo sapiens" xref: Reactome:REACT_264 "Phosphorylation of Wee1 kinase by Chk1, Homo sapiens" xref: Reactome:REACT_28054 "Phosphorylation of BRCA1 at multiple sites by ATM, Mus musculus" xref: Reactome:REACT_28091 "Inactivation of Wee1 kinase, Canis familiaris" xref: Reactome:REACT_28113 "RAF1 phosphorylates MEK1, Taeniopygia guttata" xref: Reactome:REACT_28163 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Canis familiaris" xref: Reactome:REACT_28264 "Phosphorylation of Wee1 kinase by Chk1, Arabidopsis thaliana" xref: Reactome:REACT_28480 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Danio rerio" xref: Reactome:REACT_28555 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Xenopus tropicalis" xref: Reactome:REACT_28681 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Rattus norvegicus" xref: Reactome:REACT_28719 "Phosphorylation and activation of eIF4B by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_28743 "RAF1 phosphorylates MEK2, Mus musculus" xref: Reactome:REACT_28746 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Danio rerio" xref: Reactome:REACT_28824 "Down Regulation of Emi1 through Phosphorylation of Emi1, Danio rerio" xref: Reactome:REACT_29029 "Phosphorylation of L1 by ERK, Caenorhabditis elegans" xref: Reactome:REACT_29168 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Canis familiaris" xref: Reactome:REACT_29201 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Saccharomyces cerevisiae" xref: Reactome:REACT_29213 "Activation of Cdc25C, Rattus norvegicus" xref: Reactome:REACT_29277 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_29284 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Xenopus tropicalis" xref: Reactome:REACT_29289 "Activation of S6K1, Gallus gallus" xref: Reactome:REACT_29300 "Phosphorylation of L1 by ERK, Drosophila melanogaster" xref: Reactome:REACT_29334 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_29395 "Phosphorylation of AKT2 by PDK1, Xenopus tropicalis" xref: Reactome:REACT_29396 "Orc1 is phosphorylated by cyclin A/CDK2, Canis familiaris" xref: Reactome:REACT_29410 "Regulation of KIF20A (MKL2) by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_29451 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Bos taurus" xref: Reactome:REACT_29588 "Phosphorylation of 4E-BP1 by activated mTORC1, Taeniopygia guttata" xref: Reactome:REACT_29614 "Regulation of NUDC by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_29689 "Cdc6 protein is phosphorylated by CDK, Bos taurus" xref: Reactome:REACT_29694 "Phosphorylation of PDE3B, Canis familiaris" xref: Reactome:REACT_29759 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Bos taurus" xref: Reactome:REACT_29788 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_29873 "Phosphorylation of APC component of the destruction complex, Taeniopygia guttata" xref: Reactome:REACT_29914 "Down Regulation of Emi1 through Phosphorylation of Emi1, Canis familiaris" xref: Reactome:REACT_30020 "Phosphorylation (Ser5) of RNA pol II CTD, Rattus norvegicus" xref: Reactome:REACT_30023 "Phosphorylation (Ser5) of RNA pol II CTD, Xenopus tropicalis" xref: Reactome:REACT_30052 "Phosphorylation of BRCA1 at multiple sites by ATM, Bos taurus" xref: Reactome:REACT_30070 "Phosphorylation of L1 by CK-II, Mus musculus" xref: Reactome:REACT_30084 "PIP2 conversion to PIP3, Canis familiaris" xref: Reactome:REACT_30113 "SOS phosphorylation and dissociation (IRS, Crk), Drosophila melanogaster" xref: Reactome:REACT_30116 "Phosphorylation and activation of eIF4B by activated S6K1, Canis familiaris" xref: Reactome:REACT_30165 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Gallus gallus" xref: Reactome:REACT_302 "Phosphorylation and activation of Chk1 by ATM, Homo sapiens" xref: Reactome:REACT_30230 "Phosphorylation of the SA2 Cohesin Complex, Caenorhabditis elegans" xref: Reactome:REACT_30345 "RAF1 phosphorylates MEK1, Gallus gallus" xref: Reactome:REACT_30490 "Inactivation of Myt1 kinase, Danio rerio" xref: Reactome:REACT_30496 "Phosphorylation of the Scc1:Cohesion Complex, Xenopus tropicalis" xref: Reactome:REACT_30679 "Phosphorylation and inactivation of eEF2K by activated S6K1, Mus musculus" xref: Reactome:REACT_30700 "Phosphorylation of BRCA1 at multiple sites by ATM, Gallus gallus" xref: Reactome:REACT_30836 "Inactivation of Myt1 kinase, Bos taurus" xref: Reactome:REACT_30921 "Phosphorylation and activation of Chk1 by ATM, Xenopus tropicalis" xref: Reactome:REACT_30938 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Canis familiaris" xref: Reactome:REACT_30948 "PIP2 conversion to PIP3, Gallus gallus" xref: Reactome:REACT_30985 "Plk1-mediated phosphorylation of Nlp, Canis familiaris" xref: Reactome:REACT_30997 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Rattus norvegicus" xref: Reactome:REACT_31081 "Phosphorylation of TSC2 by PKB, Canis familiaris" xref: Reactome:REACT_31149 "Phosphorylation of the Scc1:Cohesion Complex, Danio rerio" xref: Reactome:REACT_31196 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Canis familiaris" xref: Reactome:REACT_31227 "Regulation of KIF20A (MKL2) by phosphorylation, Gallus gallus" xref: Reactome:REACT_31273 "Phosphorylation of the Scc1:Cohesion Complex, Canis familiaris" xref: Reactome:REACT_31290 "Orc1 is phosphorylated by cyclin A/CDK2, Rattus norvegicus" xref: Reactome:REACT_31293 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Danio rerio" xref: Reactome:REACT_31449 "Phosphorylation and activation of CHK2 by ATM, Danio rerio" xref: Reactome:REACT_31466 "Activation of S6K1, Bos taurus" xref: Reactome:REACT_31519 "Phosphorylation of the SA2 Cohesin Complex, Danio rerio" xref: Reactome:REACT_31536 "Phosphorylation of NBS1 by ATM, Taeniopygia guttata" xref: Reactome:REACT_31571 "Autophosphorylation of PAK-2p34 in the activation loop, Gallus gallus" xref: Reactome:REACT_31625 "Phosphorylation of L1 by ERK, Taeniopygia guttata" xref: Reactome:REACT_31639 "SOS phosphorylation and dissociation (SHC), Rattus norvegicus" xref: Reactome:REACT_31868 "Phosphorylation and activation of CHK2 by ATM, Canis familiaris" xref: Reactome:REACT_31915 "Phosphorylation of L1 by CK-II, Drosophila melanogaster" xref: Reactome:REACT_31935 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Sus scrofa" xref: Reactome:REACT_31984 "Phosphorylation (Ser5) of RNA pol II CTD, Arabidopsis thaliana" xref: Reactome:REACT_32009 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Mus musculus" xref: Reactome:REACT_32077 "Inactivation of Myt1 kinase, Dictyostelium discoideum" xref: Reactome:REACT_32079 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Danio rerio" xref: Reactome:REACT_32145 "Phosphorylation of COP1 at Ser-387 by ATM, Canis familiaris" xref: Reactome:REACT_32150 "Phosphorylation of NBS1 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_32271 "Phosphorylation of cPLA2 by ERK-2, Taeniopygia guttata" xref: Reactome:REACT_32358 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Canis familiaris" xref: Reactome:REACT_32374 "Mcm2-7 is phosphorylated by DDK, Canis familiaris" xref: Reactome:REACT_32438 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Sus scrofa" xref: Reactome:REACT_32492 "Phosphorylation of BRCA1 at multiple sites by ATM, Rattus norvegicus" xref: Reactome:REACT_32565 "Phosphorylation of NBS1 by ATM, Gallus gallus" xref: Reactome:REACT_32598 "Phosphorylation and activation of eIF4B by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_32620 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Bos taurus" xref: Reactome:REACT_32845 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Rattus norvegicus" xref: Reactome:REACT_32906 "Phosphorylation and inactivation of eEF2K by activated S6K1, Sus scrofa" xref: Reactome:REACT_32956 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Mus musculus" xref: Reactome:REACT_33003 "Phosphorylation of the SA2 Cohesin Complex, Dictyostelium discoideum" xref: Reactome:REACT_33009 "Phosphorylation of L1 by ERK, Danio rerio" xref: Reactome:REACT_33080 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Taeniopygia guttata" xref: Reactome:REACT_33369 "Phosphorylation of NBS1 by ATM, Rattus norvegicus" xref: Reactome:REACT_33385 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Canis familiaris" xref: Reactome:REACT_33519 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Mus musculus" xref: Reactome:REACT_33532 "Phosphorylation of complexed TSC2 by PKB, Bos taurus" xref: Reactome:REACT_33692 "Phosphorylation of BRCA1 at multiple sites by ATM, Taeniopygia guttata" xref: Reactome:REACT_33840 "Regulation of KIF23 (MKLP1) by phosphorylation, Schizosaccharomyces pombe" xref: Reactome:REACT_33928 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Sus scrofa" xref: Reactome:REACT_33979 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Rattus norvegicus" xref: Reactome:REACT_34080 "Phosphorylation of PD-1, Mus musculus" xref: Reactome:REACT_34111 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Canis familiaris" xref: Reactome:REACT_34145 "Phosphorylation of cPLA2 by ERK-2, Xenopus tropicalis" xref: Reactome:REACT_34222 "Phosphorylation of L1 by ERK, Rattus norvegicus" xref: Reactome:REACT_34285 "Activation of Cdc25C, Bos taurus" xref: Reactome:REACT_34310 "Phosphorylation and activation of Chk1 by ATM, Bos taurus" xref: Reactome:REACT_34403 "Phosphorylation (Ser5) of RNA pol II CTD, Danio rerio" xref: Reactome:REACT_34514 "Phosphorylation and inactivation of eEF2K by activated S6K1, Danio rerio" xref: Reactome:REACT_34516 "Cdc6 protein is phosphorylated by CDK, Canis familiaris" xref: Reactome:REACT_34607 "Phosphorylation of 4E-BP1 by activated mTORC1, Bos taurus" xref: Reactome:REACT_34741 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Rattus norvegicus" xref: Reactome:REACT_34788 "Phosphorylation and inactivation of eEF2K by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_34804 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Gallus gallus" xref: Reactome:REACT_384 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Homo sapiens" xref: Reactome:REACT_414 "Inactivation of Myt1 kinase, Homo sapiens" xref: Reactome:REACT_41715 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Mus musculus" xref: Reactome:REACT_43 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Homo sapiens" xref: Reactome:REACT_496 "Down Regulation of Emi1 through Phosphorylation of Emi1, Homo sapiens" xref: Reactome:REACT_54449 "Phosphorylation and activation of eIF4G by activated S6K1, Mus musculus" xref: Reactome:REACT_545 "RAF1 phosphorylates MEK1, Homo sapiens" xref: Reactome:REACT_559 "Phosphorylation and activation of Chk1 by ATM kinase, Mus musculus" xref: Reactome:REACT_58131 "PIP2 conversion to PIP3, Mus musculus" xref: Reactome:REACT_6139 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6170 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex, Homo sapiens" xref: Reactome:REACT_6178 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6234 "Phosphorylation (Ser5) of RNA pol II CTD, Homo sapiens" xref: Reactome:REACT_6297 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Homo sapiens" xref: Reactome:REACT_6311 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex, Homo sapiens" xref: Reactome:REACT_6314 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6316 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex, Human immunodeficiency virus 1" xref: Reactome:REACT_6327 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6342 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Homo sapiens" xref: Reactome:REACT_6353 "Phosphorylation of Cyclin B1 in the CRS domain, Homo sapiens" xref: Reactome:REACT_6725 "Phosphorylation of TSC2 by PKB, Homo sapiens" xref: Reactome:REACT_6778 "Phosphorylation and activation of eIF4B by activated S6K1, Homo sapiens" xref: Reactome:REACT_6859 "Free APC/C phosphorylated by Plk1, Homo sapiens" xref: Reactome:REACT_6861 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Homo sapiens" xref: Reactome:REACT_6870 "Phosphorylation and activation of eIF4G by activated S6K1, Homo sapiens" xref: Reactome:REACT_6873 "Phosphorylation of 4E-BP1 by activated mTORC1, Homo sapiens" xref: Reactome:REACT_6883 "Phosphorylation and inactivation of eEF2K by activated S6K1, Homo sapiens" xref: Reactome:REACT_6912 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Homo sapiens" xref: Reactome:REACT_6948 "Activation of S6K1, Homo sapiens" xref: Reactome:REACT_6952 "Phosphorylation of complexed TSC2 by PKB, Homo sapiens" xref: Reactome:REACT_76979 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Danio rerio" xref: Reactome:REACT_77040 "Phosphorylation of COP1 at Ser-387 by ATM, Oryza sativa" xref: Reactome:REACT_77074 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Mus musculus" xref: Reactome:REACT_77179 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Bos taurus" xref: Reactome:REACT_77231 "Phosphorylation of DLC2 by MAPK-8, Gallus gallus" xref: Reactome:REACT_77234 "Plk1-mediated phosphorylation of Nlp, Gallus gallus" xref: Reactome:REACT_773 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Homo sapiens" xref: Reactome:REACT_77326 "RAF1 phosphorylates MEK2, Taeniopygia guttata" xref: Reactome:REACT_77362 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Rattus norvegicus" xref: Reactome:REACT_77365 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Xenopus tropicalis" xref: Reactome:REACT_77397 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Mus musculus" xref: Reactome:REACT_77407 "Regulation of NUDC by phosphorylation, Bos taurus" xref: Reactome:REACT_77443 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Danio rerio" xref: Reactome:REACT_77450 "Phosphorylation of L1 by CK-II, Sus scrofa" xref: Reactome:REACT_77535 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Mus musculus" xref: Reactome:REACT_77550 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_77566 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Gallus gallus" xref: Reactome:REACT_77606 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Canis familiaris" xref: Reactome:REACT_77615 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Gallus gallus" xref: Reactome:REACT_77654 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_77660 "Regulation of KIF23 (MKLP1) by phosphorylation, Caenorhabditis elegans" xref: Reactome:REACT_77733 "Phosphorylation of PDE3B, Danio rerio" xref: Reactome:REACT_77834 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Rattus norvegicus" xref: Reactome:REACT_77857 "Phosphorylation (Ser5) of RNA pol II CTD, Drosophila melanogaster" xref: Reactome:REACT_77897 "Phosphorylation of Wee1 kinase by Chk1, Taeniopygia guttata" xref: Reactome:REACT_77911 "Mcm2-7 is phosphorylated by DDK, Taeniopygia guttata" xref: Reactome:REACT_77928 "Autophosphorylation of PAK-2p34 in the activation loop, Sus scrofa" xref: Reactome:REACT_77949 "Phosphorylation of Wee1 kinase by Chk1, Drosophila melanogaster" xref: Reactome:REACT_77977 "Phosphorylation of Cyclin B1 in the CRS domain, Bos taurus" xref: Reactome:REACT_78014 "Plk1-mediated phosphorylation of Nlp, Taeniopygia guttata" xref: Reactome:REACT_78035 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_78087 "Phosphorylation of TSC2 by PKB, Xenopus tropicalis" xref: Reactome:REACT_78121 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Gallus gallus" xref: Reactome:REACT_78226 "Regulation of NUDC by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_78281 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_78427 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Danio rerio" xref: Reactome:REACT_78450 "Phosphorylation and activation of eIF4B by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_78451 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Taeniopygia guttata" xref: Reactome:REACT_78503 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Bos taurus" xref: Reactome:REACT_78533 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Danio rerio" xref: Reactome:REACT_78539 "Down Regulation of Emi1 through Phosphorylation of Emi1, Xenopus tropicalis" xref: Reactome:REACT_78556 "Free APC/C phosphorylated by Plk1, Drosophila melanogaster" xref: Reactome:REACT_78625 "Phosphorylation and inactivation of eEF2K by activated S6K1, Caenorhabditis elegans" xref: Reactome:REACT_78651 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_78696 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_78748 "Cdc6 protein is phosphorylated by CDK, Drosophila melanogaster" xref: Reactome:REACT_78901 "Phosphorylation (Ser5) of RNA pol II CTD, Mus musculus" xref: Reactome:REACT_79012 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Schizosaccharomyces pombe" xref: Reactome:REACT_79039 "Autophosphorylation of PAK-2p34 in the activation loop, Caenorhabditis elegans" xref: Reactome:REACT_79087 "Phosphorylation of Wee1 kinase by Chk1, Oryza sativa" xref: Reactome:REACT_79125 "SOS phosphorylation and dissociation (IRS), Bos taurus" xref: Reactome:REACT_79182 "Phosphorylation of Cyclin B1 in the CRS domain, Canis familiaris" xref: Reactome:REACT_79208 "Mcm2-7 is phosphorylated by DDK, Bos taurus" xref: Reactome:REACT_79220 "Phosphorylation of 4E-BP1 by activated mTORC1, Canis familiaris" xref: Reactome:REACT_79255 "Phosphorylation of p53 at ser-15 by ATM kinase, Danio rerio" xref: Reactome:REACT_79372 "Cdc6 protein is phosphorylated by CDK, Danio rerio" xref: Reactome:REACT_79573 "Phosphorylation of p53 at ser-15 by ATM kinase, Mus musculus" xref: Reactome:REACT_79686 "Phosphorylation of the Scc1:Cohesion Complex, Drosophila melanogaster" xref: Reactome:REACT_79694 "Autophosphorylation of PAK-2p34 in the activation loop, Xenopus tropicalis" xref: Reactome:REACT_79700 "Activation of S6K1, Taeniopygia guttata" xref: Reactome:REACT_79709 "Orc1 is phosphorylated by cyclin A/CDK2, Mus musculus" xref: Reactome:REACT_79720 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Danio rerio" xref: Reactome:REACT_80110 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_80144 "Phosphorylation of complexed TSC2 by PKB, Sus scrofa" xref: Reactome:REACT_80185 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Mus musculus" xref: Reactome:REACT_80213 "Activation of S6K1, Canis familiaris" xref: Reactome:REACT_80218 "Phosphorylation of the Scc1:Cohesion Complex, Dictyostelium discoideum" xref: Reactome:REACT_80239 "Regulation of KIF20A (MKL2) by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_80255 "Mcm2-7 is phosphorylated by DDK, Mus musculus" xref: Reactome:REACT_80591 "Regulation of KIF20A (MKL2) by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_80606 "Phosphorylation of NBS1 by ATM, Oryza sativa" xref: Reactome:REACT_80617 "Inactivation of Wee1 kinase, Xenopus tropicalis" xref: Reactome:REACT_80632 "Phosphorylation of L1 by ERK, Schizosaccharomyces pombe" xref: Reactome:REACT_80665 "Down Regulation of Emi1 through Phosphorylation of Emi1, Taeniopygia guttata" xref: Reactome:REACT_80684 "Phosphorylation of COP1 at Ser-387 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_80689 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Oryza sativa" xref: Reactome:REACT_80699 "PIP2 conversion to PIP3, Danio rerio" xref: Reactome:REACT_80700 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Sus scrofa" xref: Reactome:REACT_80714 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_80804 "Phosphorylation of PDE3B, Bos taurus" xref: Reactome:REACT_80853 "Phosphorylation (Ser5) of RNA pol II CTD, Dictyostelium discoideum" xref: Reactome:REACT_80860 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Rattus norvegicus" xref: Reactome:REACT_80909 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Drosophila melanogaster" xref: Reactome:REACT_81027 "PIP2 conversion to PIP3, Sus scrofa" xref: Reactome:REACT_81148 "Phosphorylation and activation of CHK2 by ATM, Taeniopygia guttata" xref: Reactome:REACT_81218 "Phosphorylation and activation of CHK2 by ATM, Rattus norvegicus" xref: Reactome:REACT_81439 "Phosphorylation of APC component of the destruction complex, Xenopus tropicalis" xref: Reactome:REACT_81458 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Bos taurus" xref: Reactome:REACT_81490 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_81590 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Bos taurus" xref: Reactome:REACT_81616 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Canis familiaris" xref: Reactome:REACT_81647 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Rattus norvegicus" xref: Reactome:REACT_81652 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Rattus norvegicus" xref: Reactome:REACT_81693 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Drosophila melanogaster" xref: Reactome:REACT_81715 "Orc1 is phosphorylated by cyclin A/CDK2, Drosophila melanogaster" xref: Reactome:REACT_81727 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Danio rerio" xref: Reactome:REACT_81864 "Phosphorylation of Cx43 by c-src, Bos taurus" xref: Reactome:REACT_81941 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Bos taurus" xref: Reactome:REACT_82037 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Mus musculus" xref: Reactome:REACT_82115 "Phosphorylation and activation of Chk1 by ATM, Saccharomyces cerevisiae" xref: Reactome:REACT_82125 "Phosphorylation of complexed TSC2 by PKB, Danio rerio" xref: Reactome:REACT_82128 "PIP2 conversion to PIP3, Taeniopygia guttata" xref: Reactome:REACT_82261 "Phosphorylation of DLC2 by MAPK-8, Xenopus tropicalis" xref: Reactome:REACT_82270 "Autophosphorylation of PAK-2p34 in the activation loop, Rattus norvegicus" xref: Reactome:REACT_82303 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Xenopus tropicalis" xref: Reactome:REACT_82310 "Phosphorylation and activation of Chk1 by ATM, Gallus gallus" xref: Reactome:REACT_82361 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_82456 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Bos taurus" xref: Reactome:REACT_82473 "Phosphorylation of the SA2 Cohesin Complex, Canis familiaris" xref: Reactome:REACT_82616 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Mus musculus" xref: Reactome:REACT_82678 "Phosphorylation of complexed TSC2 by PKB, Rattus norvegicus" xref: Reactome:REACT_82728 "Plk1-mediated phosphorylation of Nlp, Mus musculus" xref: Reactome:REACT_82751 "Down Regulation of Emi1 through Phosphorylation of Emi1, Rattus norvegicus" xref: Reactome:REACT_82824 "Inactivation of Wee1 kinase, Rattus norvegicus" xref: Reactome:REACT_82901 "Phosphorylation of DLC2 by MAPK-8, Canis familiaris" xref: Reactome:REACT_82927 "PIP2 conversion to PIP3, Rattus norvegicus" xref: Reactome:REACT_83006 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Caenorhabditis elegans" xref: Reactome:REACT_83089 "Inactivation of Myt1 kinase, Saccharomyces cerevisiae" xref: Reactome:REACT_83110 "Phosphorylation (Ser5) of RNA pol II CTD, Schizosaccharomyces pombe" xref: Reactome:REACT_83178 "Phosphorylation and activation of Chk1 by ATM, Oryza sativa" xref: Reactome:REACT_83187 "Phosphorylation of the SA2 Cohesin Complex, Mus musculus" xref: Reactome:REACT_83239 "Phosphorylation and activation of eIF4G by activated S6K1, Gallus gallus" xref: Reactome:REACT_83279 "Phosphorylation of NBS1 by ATM, Canis familiaris" xref: Reactome:REACT_83297 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Danio rerio" xref: Reactome:REACT_83436 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Arabidopsis thaliana" xref: Reactome:REACT_83476 "Phosphorylation and activation of CHK2 by ATM, Mus musculus" xref: Reactome:REACT_83529 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_83533 "Phosphorylation and activation of Chk1 by ATM, Rattus norvegicus" xref: Reactome:REACT_83579 "Phosphorylation of Wee1 kinase by Chk1, Gallus gallus" xref: Reactome:REACT_83582 "Plk1-mediated phosphorylation of Nlp, Danio rerio" xref: Reactome:REACT_83671 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Taeniopygia guttata" xref: Reactome:REACT_83696 "Free APC/C phosphorylated by Plk1, Bos taurus" xref: Reactome:REACT_83709 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Mus musculus" xref: Reactome:REACT_83727 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Gallus gallus" xref: Reactome:REACT_83899 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Sus scrofa" xref: Reactome:REACT_83979 "Phosphorylation of COP1 at Ser-387 by ATM, Mus musculus" xref: Reactome:REACT_84080 "Phosphorylation of the SA2 Cohesin Complex, Xenopus tropicalis" xref: Reactome:REACT_84082 "Phosphorylation of Wee1 kinase by Chk1, Rattus norvegicus" xref: Reactome:REACT_84208 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Mus musculus" xref: Reactome:REACT_84273 "Phosphorylation of L1 by ERK, Sus scrofa" xref: Reactome:REACT_84348 "Phosphorylation of COP1 at Ser-387 by ATM, Taeniopygia guttata" xref: Reactome:REACT_84405 "Phosphorylation of p53 at ser-15 by ATM kinase, Rattus norvegicus" xref: Reactome:REACT_845 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Homo sapiens" xref: Reactome:REACT_84560 "Cdc6 protein is phosphorylated by CDK, Saccharomyces cerevisiae" xref: Reactome:REACT_84656 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Bos taurus" xref: Reactome:REACT_84932 "Phosphorylation of Wee1 kinase by Chk1, Sus scrofa" xref: Reactome:REACT_85009 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Taeniopygia guttata" xref: Reactome:REACT_85017 "Activation of S6K1, Dictyostelium discoideum" xref: Reactome:REACT_85044 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Canis familiaris" xref: Reactome:REACT_85066 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Taeniopygia guttata" xref: Reactome:REACT_85256 "Phosphorylation of Cdc25C at Ser216, Mus musculus" xref: Reactome:REACT_85328 "Regulation of KIF20A (MKL2) by phosphorylation, Mus musculus" xref: Reactome:REACT_85379 "Phosphorylation of Cx43 by c-src, Sus scrofa" xref: Reactome:REACT_85449 "Phosphorylation and activation of eIF4G by activated S6K1, Bos taurus" xref: Reactome:REACT_85586 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Gallus gallus" xref: Reactome:REACT_85699 "Phosphorylation of Cyclin B1 in the CRS domain, Rattus norvegicus" xref: Reactome:REACT_85720 "Phosphorylation of L1 by ERK, Canis familiaris" xref: Reactome:REACT_85745 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_85751 "Phosphorylation of BRCA1 at multiple sites by ATM, Canis familiaris" xref: Reactome:REACT_85812 "Phosphorylation and activation of Chk1 by ATM, Drosophila melanogaster" xref: Reactome:REACT_85836 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Gallus gallus" xref: Reactome:REACT_85871 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Mus musculus" xref: Reactome:REACT_86014 "Phosphorylation of the SA2 Cohesin Complex, Bos taurus" xref: Reactome:REACT_86033 "Phosphorylation and activation of CHK2 by ATM, Schizosaccharomyces pombe" xref: Reactome:REACT_86061 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Bos taurus" xref: Reactome:REACT_86092 "Phosphorylation of COP1 at Ser-387 by ATM, Bos taurus" xref: Reactome:REACT_86211 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Saccharomyces cerevisiae" xref: Reactome:REACT_86252 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Drosophila melanogaster" xref: Reactome:REACT_86261 "Regulation of NUDC by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_86277 "Phosphorylation of TSC2 by PKB, Bos taurus" xref: Reactome:REACT_86365 "Phosphorylation and activation of eIF4G by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_86372 "Akt1 phosphorylates BAD protein, Mus musculus" xref: Reactome:REACT_86415 "Phosphorylation of Cx43 by c-src, Xenopus tropicalis" xref: Reactome:REACT_86422 "Phosphorylation of PD-1, Rattus norvegicus" xref: Reactome:REACT_86533 "Cdc6 protein is phosphorylated by CDK, Sus scrofa" xref: Reactome:REACT_86736 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Rattus norvegicus" xref: Reactome:REACT_86800 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Danio rerio" xref: Reactome:REACT_86867 "Phosphorylation of p53 at ser-15 by ATM kinase, Bos taurus" xref: Reactome:REACT_86952 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Sus scrofa" xref: Reactome:REACT_86967 "Phosphorylation (Ser5) of RNA pol II CTD, Gallus gallus" xref: Reactome:REACT_87010 "Regulation of NUDC by phosphorylation, Danio rerio" xref: Reactome:REACT_87121 "Phosphorylation of cPLA2 by ERK-2, Bos taurus" xref: Reactome:REACT_87149 "Phosphorylation of L1 by CK-II, Danio rerio" xref: Reactome:REACT_87212 "Phosphorylation of Cx43 by c-src, Mus musculus" xref: Reactome:REACT_87222 "Cdc6 protein is phosphorylated by CDK, Schizosaccharomyces pombe" xref: Reactome:REACT_87298 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Sus scrofa" xref: Reactome:REACT_87329 "Regulation of KIF23 (MKLP1) by phosphorylation, Mus musculus" xref: Reactome:REACT_87391 "Phosphorylation of Cx43 by c-src, Rattus norvegicus" xref: Reactome:REACT_87424 "SOS phosphorylation and dissociation (SHC), Danio rerio" xref: Reactome:REACT_87437 "Phosphorylation of AKT2 by PDK1, Caenorhabditis elegans" xref: Reactome:REACT_87485 "Activation of S6K1, Xenopus tropicalis" xref: Reactome:REACT_87497 "Akt1 phosphorylates BAD protein, Bos taurus" xref: Reactome:REACT_87503 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Xenopus tropicalis" xref: Reactome:REACT_87523 "Phosphorylation of Cyclin B1 in the CRS domain, Mus musculus" xref: Reactome:REACT_87534 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Gallus gallus" xref: Reactome:REACT_87593 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Gallus gallus" xref: Reactome:REACT_87650 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_87679 "Phosphorylation of PDE3B, Xenopus tropicalis" xref: Reactome:REACT_87753 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Bos taurus" xref: Reactome:REACT_87880 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Danio rerio" xref: Reactome:REACT_87967 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Xenopus tropicalis" xref: Reactome:REACT_88025 "Activation of S6K1, Mus musculus" xref: Reactome:REACT_88055 "Phosphorylation of NBS1 by ATM, Sus scrofa" xref: Reactome:REACT_88091 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Xenopus tropicalis" xref: Reactome:REACT_88220 "Regulation of KIF23 (MKLP1) by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_88298 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Taeniopygia guttata" xref: Reactome:REACT_88326 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Canis familiaris" xref: Reactome:REACT_88374 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_88421 "Phosphorylation and inactivation of eEF2K by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_88430 "Orc1 is phosphorylated by cyclin A/CDK2, Bos taurus" xref: Reactome:REACT_88440 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Caenorhabditis elegans" xref: Reactome:REACT_88458 "Phosphorylation of cPLA2 by ERK-2, Danio rerio" xref: Reactome:REACT_88486 "Inactivation of Wee1 kinase, Taeniopygia guttata" xref: Reactome:REACT_88516 "Cdc6 protein is phosphorylated by CDK, Rattus norvegicus" xref: Reactome:REACT_88548 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Taeniopygia guttata" xref: Reactome:REACT_88564 "Plk1-mediated phosphorylation of Nlp, Xenopus tropicalis" xref: Reactome:REACT_88590 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Rattus norvegicus" xref: Reactome:REACT_88665 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Danio rerio" xref: Reactome:REACT_88668 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Drosophila melanogaster" xref: Reactome:REACT_88766 "Phosphorylation (Ser5) of RNA pol II CTD, Oryza sativa" xref: Reactome:REACT_88871 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Rattus norvegicus" xref: Reactome:REACT_88928 "Autophosphorylation of PAK-2p34 in the activation loop, Drosophila melanogaster" xref: Reactome:REACT_88987 "Free APC/C phosphorylated by Plk1, Canis familiaris" xref: Reactome:REACT_89001 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Gallus gallus" xref: Reactome:REACT_89026 "Phosphorylation of PD-1, Gallus gallus" xref: Reactome:REACT_89122 "Activation of Cdc25C, Canis familiaris" xref: Reactome:REACT_89366 "Phosphorylation of APC component of the destruction complex, Canis familiaris" xref: Reactome:REACT_89427 "Phosphorylation of AKT2 by PDK1, Bos taurus" xref: Reactome:REACT_89464 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_89547 "Phosphorylation of NBS1 by ATM, Xenopus tropicalis" xref: Reactome:REACT_89579 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_89769 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Taeniopygia guttata" xref: Reactome:REACT_89794 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Mus musculus" xref: Reactome:REACT_89879 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Mus musculus" xref: Reactome:REACT_89988 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_9007 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Homo sapiens" xref: Reactome:REACT_90132 "Phosphorylation of AKT2 by PDK1, Sus scrofa" xref: Reactome:REACT_90167 "Phosphorylation of Wee1 kinase by Chk1, Bos taurus" xref: Reactome:REACT_90220 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_90227 "Phosphorylation of AKT2 by PDK1, Mus musculus" xref: Reactome:REACT_90290 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Taeniopygia guttata" xref: Reactome:REACT_90364 "Regulation of NUDC by phosphorylation, Canis familiaris" xref: Reactome:REACT_90426 "Phosphorylation of Wee1 kinase by Chk1, Mus musculus" xref: Reactome:REACT_90449 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Canis familiaris" xref: Reactome:REACT_90562 "Regulation of NUDC by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_9057 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Homo sapiens" xref: Reactome:REACT_9067 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Homo sapiens" xref: Reactome:REACT_90675 "Phosphorylation (Ser5) of RNA pol II CTD, Caenorhabditis elegans" xref: Reactome:REACT_907 "Mcm2-7 is phosphorylated by DDK, Homo sapiens" xref: Reactome:REACT_9070 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Homo sapiens" xref: Reactome:REACT_908 "Phosphorylation of AKT2 by PDK1, Homo sapiens" xref: Reactome:REACT_90917 "Phosphorylation of Wee1 kinase by Chk1, Canis familiaris" xref: Reactome:REACT_91050 "SOS phosphorylation and dissociation (IRS, Crk), Mus musculus" xref: Reactome:REACT_91062 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Bos taurus" xref: Reactome:REACT_91085 "Inactivation of Wee1 kinase, Danio rerio" xref: Reactome:REACT_91156 "Phosphorylation and activation of CHK2 by ATM, Gallus gallus" xref: Reactome:REACT_91157 "Phosphorylation (Ser5) of RNA pol II CTD, Saccharomyces cerevisiae" xref: Reactome:REACT_91196 "Phosphorylation of 4E-BP1 by activated mTORC1, Mus musculus" xref: Reactome:REACT_91197 "Phosphorylation and activation of eIF4B by activated S6K1, Mus musculus" xref: Reactome:REACT_91240 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Xenopus tropicalis" xref: Reactome:REACT_91263 "Down Regulation of Emi1 through Phosphorylation of Emi1, Gallus gallus" xref: Reactome:REACT_91382 "SOS phosphorylation and dissociation (IRS), Danio rerio" xref: Reactome:REACT_91470 "Regulation of KIF20A (MKL2) by phosphorylation, Canis familiaris" xref: Reactome:REACT_91501 "PIP2 conversion to PIP3, Bos taurus" xref: Reactome:REACT_91541 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_91574 "Phosphorylation of DLC2 by MAPK-8, Rattus norvegicus" xref: Reactome:REACT_91643 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Drosophila melanogaster" xref: Reactome:REACT_91684 "Phosphorylation of the SA2 Cohesin Complex, Drosophila melanogaster" xref: Reactome:REACT_91760 "Regulation of KIF23 (MKLP1) by phosphorylation, Danio rerio" xref: Reactome:REACT_91937 "Phosphorylation of APC component of the destruction complex, Bos taurus" xref: Reactome:REACT_92033 "Inactivation of Myt1 kinase, Caenorhabditis elegans" xref: Reactome:REACT_92108 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Rattus norvegicus" xref: Reactome:REACT_92126 "Activation of S6K1, Oryza sativa" xref: Reactome:REACT_92148 "Autophosphorylation of PAK-2p34 in the activation loop, Danio rerio" xref: Reactome:REACT_92219 "Phosphorylation of PDE3B, Caenorhabditis elegans" xref: Reactome:REACT_92247 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Canis familiaris" xref: Reactome:REACT_92407 "Regulation of KIF23 (MKLP1) by phosphorylation, Canis familiaris" xref: Reactome:REACT_92735 "Autophosphorylation of PAK-2p34 in the activation loop, Taeniopygia guttata" xref: Reactome:REACT_92736 "Phosphorylation of L1 by ERK, Gallus gallus" xref: Reactome:REACT_92804 "Phosphorylation of Wee1 kinase by Chk1, Danio rerio" xref: Reactome:REACT_92852 "SOS phosphorylation and dissociation (SHC), Canis familiaris" xref: Reactome:REACT_92889 "Phosphorylation of TSC2 by PKB, Sus scrofa" xref: Reactome:REACT_92915 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Danio rerio" xref: Reactome:REACT_92929 "RAF1 phosphorylates MEK1, Danio rerio" xref: Reactome:REACT_92951 "Phosphorylation and activation of Chk1 by ATM, Canis familiaris" xref: Reactome:REACT_93018 "RAF1 phosphorylates MEK1, Bos taurus" xref: Reactome:REACT_93105 "Phosphorylation of cPLA2 by ERK-2, Rattus norvegicus" xref: Reactome:REACT_93124 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Mus musculus" xref: Reactome:REACT_93149 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_93166 "Phosphorylation and activation of Chk1 by ATM, Taeniopygia guttata" xref: Reactome:REACT_93219 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Xenopus tropicalis" xref: Reactome:REACT_93221 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_93346 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Mus musculus" xref: Reactome:REACT_93366 "Phosphorylation of cPLA2 by ERK-2, Canis familiaris" xref: Reactome:REACT_93414 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_93440 "Regulation of KIF20A (MKL2) by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_93441 "Regulation of KIF23 (MKLP1) by phosphorylation, Gallus gallus" xref: Reactome:REACT_93613 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Rattus norvegicus" xref: Reactome:REACT_93615 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Bos taurus" xref: Reactome:REACT_937 "Phosphorylation of BRCA1 at multiple sites by ATM, Homo sapiens" xref: Reactome:REACT_93706 "RAF1 phosphorylates MEK1, Canis familiaris" xref: Reactome:REACT_93746 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Mus musculus" xref: Reactome:REACT_93878 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Gallus gallus" xref: Reactome:REACT_94017 "SOS phosphorylation and dissociation (IRS, Crk), Bos taurus" xref: Reactome:REACT_94113 "Phosphorylation of Cx43 by c-src, Canis familiaris" xref: Reactome:REACT_94151 "Phosphorylation of Wee1 kinase by Chk1, Xenopus tropicalis" xref: Reactome:REACT_94248 "SOS phosphorylation and dissociation (SHC), Bos taurus" xref: Reactome:REACT_94258 "Phosphorylation of p53 at ser-15 by ATM kinase, Sus scrofa" xref: Reactome:REACT_94298 "Phosphorylation of Cyclin B1 in the CRS domain, Danio rerio" xref: Reactome:REACT_94397 "Orc1 is phosphorylated by cyclin A/CDK2, Danio rerio" xref: Reactome:REACT_94428 "Phosphorylation of PD-1, Bos taurus" xref: Reactome:REACT_94452 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Bos taurus" xref: Reactome:REACT_94464 "Phosphorylation and activation of eIF4B by activated S6K1, Danio rerio" xref: Reactome:REACT_94562 "Phosphorylation of the Scc1:Cohesion Complex, Caenorhabditis elegans" xref: Reactome:REACT_94615 "SOS phosphorylation and dissociation (IRS, Crk), Rattus norvegicus" xref: Reactome:REACT_94784 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Rattus norvegicus" xref: Reactome:REACT_94817 "Phosphorylation of the SA2 Cohesin Complex, Rattus norvegicus" xref: Reactome:REACT_94947 "Autophosphorylation of PAK-2p34 in the activation loop, Canis familiaris" xref: Reactome:REACT_95052 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Oryza sativa" xref: Reactome:REACT_95087 "Phosphorylation of the Scc1:Cohesion Complex, Bos taurus" xref: Reactome:REACT_95088 "Inactivation of Wee1 kinase, Mus musculus" xref: Reactome:REACT_95089 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Bos taurus" xref: Reactome:REACT_95155 "Regulation of NUDC by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_95163 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Mus musculus" xref: Reactome:REACT_95437 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_95461 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Bos taurus" xref: Reactome:REACT_95504 "Phosphorylation of Cdc25C at Ser216, Xenopus tropicalis" xref: Reactome:REACT_95769 "PIP2 conversion to PIP3, Xenopus tropicalis" xref: Reactome:REACT_96 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Homo sapiens" xref: Reactome:REACT_96039 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Canis familiaris" xref: Reactome:REACT_96088 "Phosphorylation of PDE3B, Sus scrofa" xref: Reactome:REACT_96097 "SOS phosphorylation and dissociation (IRS), Rattus norvegicus" xref: Reactome:REACT_96102 "Phosphorylation of Cx43 by c-src, Gallus gallus" xref: Reactome:REACT_96129 "Phosphorylation and activation of eIF4G by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_96200 "Regulation of NUDC by phosphorylation, Gallus gallus" xref: Reactome:REACT_96208 "Phosphorylation of COP1 at Ser-387 by ATM, Sus scrofa" xref: Reactome:REACT_96218 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_96356 "Free APC/C phosphorylated by Plk1, Rattus norvegicus" xref: Reactome:REACT_96461 "Phosphorylation of L1 by CK-II, Bos taurus" xref: Reactome:REACT_96468 "Autophosphorylation of PAK-2p34 in the activation loop, Mus musculus" xref: Reactome:REACT_96483 "Phosphorylation of COP1 at Ser-387 by ATM, Gallus gallus" xref: Reactome:REACT_96500 "RAF1 phosphorylates MEK2, Gallus gallus" xref: Reactome:REACT_96524 "Activation of Cdc25C, Xenopus tropicalis" xref: Reactome:REACT_96656 "Plk1-mediated phosphorylation of Nlp, Rattus norvegicus" xref: Reactome:REACT_96666 "Phosphorylation and activation of CHK2 by ATM, Saccharomyces cerevisiae" xref: Reactome:REACT_96758 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Canis familiaris" xref: Reactome:REACT_96793 "Activation of S6K1, Danio rerio" xref: Reactome:REACT_96797 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Rattus norvegicus" xref: Reactome:REACT_96877 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Sus scrofa" xref: Reactome:REACT_96899 "Phosphorylation of TSC2 by PKB, Rattus norvegicus" xref: Reactome:REACT_96968 "Cdc6 protein is phosphorylated by CDK, Mus musculus" xref: Reactome:REACT_97193 "Phosphorylation and activation of eIF4G by activated S6K1, Canis familiaris" xref: Reactome:REACT_97218 "Orc1 is phosphorylated by cyclin A/CDK2, Xenopus tropicalis" xref: Reactome:REACT_97282 "Activation of S6K1, Sus scrofa" xref: Reactome:REACT_97299 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Mus musculus" xref: Reactome:REACT_97458 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Dictyostelium discoideum" xref: Reactome:REACT_97577 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Bos taurus" xref: Reactome:REACT_97661 "Mcm2-7 is phosphorylated by DDK, Gallus gallus" xref: Reactome:REACT_97667 "Phosphorylation of complexed TSC2 by PKB, Canis familiaris" xref: Reactome:REACT_97748 "Phosphorylation of cPLA2 by ERK-2, Mus musculus" xref: Reactome:REACT_97759 "Phosphorylation of Cx43 by c-src, Danio rerio" xref: Reactome:REACT_97847 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Mus musculus" xref: Reactome:REACT_97905 "Phosphorylation of BRCA1 at multiple sites by ATM, Xenopus tropicalis" xref: Reactome:REACT_98024 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Mus musculus" xref: Reactome:REACT_98050 "Phosphorylation of Cdc25C at Ser216, Canis familiaris" xref: Reactome:REACT_98066 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Saccharomyces cerevisiae" xref: Reactome:REACT_98109 "Regulation of NUDC by phosphorylation, Mus musculus" xref: Reactome:REACT_98176 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Bos taurus" xref: Reactome:REACT_98213 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Xenopus tropicalis" xref: Reactome:REACT_98253 "RAF1 phosphorylates MEK2, Bos taurus" xref: Reactome:REACT_98296 "Phosphorylation of Cyclin B1 in the CRS domain, Drosophila melanogaster" xref: Reactome:REACT_98373 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Drosophila melanogaster" xref: Reactome:REACT_98378 "Phosphorylation of COP1 at Ser-387 by ATM, Danio rerio" xref: Reactome:REACT_98395 "Phosphorylation and activation of Chk1 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_98434 "Phosphorylation and inactivation of eEF2K by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_98436 "Phosphorylation of 4E-BP1 by activated mTORC1, Gallus gallus" xref: Reactome:REACT_98443 "Inactivation of Wee1 kinase, Gallus gallus" xref: Reactome:REACT_98493 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Drosophila melanogaster" xref: Reactome:REACT_98558 "Autophosphorylation of PAK-2p34 in the activation loop, Saccharomyces cerevisiae" xref: Reactome:REACT_98560 "Phosphorylation and activation of CHK2 by ATM, Xenopus tropicalis" xref: Reactome:REACT_98663 "Regulation of KIF23 (MKLP1) by phosphorylation, Bos taurus" xref: Reactome:REACT_98708 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_98731 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Danio rerio" xref: Reactome:REACT_98738 "Phosphorylation of TSC2 by PKB, Danio rerio" xref: Reactome:REACT_98741 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Bos taurus" xref: Reactome:REACT_98779 "Phosphorylation of Cx43 by c-src, Taeniopygia guttata" xref: Reactome:REACT_988 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Homo sapiens" xref: Reactome:REACT_98847 "Phosphorylation of complexed TSC2 by PKB, Mus musculus" xref: Reactome:REACT_98908 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_98913 "Phosphorylation of PD-1, Canis familiaris" xref: Reactome:REACT_98971 "Phosphorylation of AKT2 by PDK1, Rattus norvegicus" xref: Reactome:REACT_98996 "Free APC/C phosphorylated by Plk1, Danio rerio" xref: Reactome:REACT_99025 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Taeniopygia guttata" xref: Reactome:REACT_99053 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Sus scrofa" xref: Reactome:REACT_99141 "Phosphorylation of NBS1 by ATM, Bos taurus" xref: Reactome:REACT_99158 "Inactivation of Wee1 kinase, Drosophila melanogaster" xref: Reactome:REACT_99207 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_99231 "Phosphorylation of AKT2 by PDK1, Danio rerio" xref: Reactome:REACT_99266 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Caenorhabditis elegans" xref: Reactome:REACT_99302 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Sus scrofa" xref: Reactome:REACT_99311 "RAF1 phosphorylates MEK1, Mus musculus" xref: Reactome:REACT_9955 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Homo sapiens" xref: Reactome:REACT_99556 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Mus musculus" xref: Reactome:REACT_99560 "RAF1 phosphorylates MEK2, Canis familiaris" xref: Reactome:REACT_9959 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Homo sapiens" xref: Reactome:REACT_99595 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Bos taurus" xref: Reactome:REACT_99713 "Phosphorylation of DLC2 by MAPK-8, Taeniopygia guttata" xref: Reactome:REACT_9978 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Homo sapiens" xref: Reactome:REACT_99785 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Canis familiaris" xref: Reactome:REACT_9983 "Phosphorylation of APC component of the destruction complex, Homo sapiens" xref: Reactome:REACT_9987 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Homo sapiens" xref: Reactome:REACT_99929 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Gallus gallus" xref: Reactome:REACT_99966 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Schizosaccharomyces pombe" xref: Reactome:REACT_9997 "Phosphorylation of Cx43 by c-src, Homo sapiens" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups relationship: part_of GO:0016310 ! phosphorylation [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0016485 name: protein processing namespace: biological_process alt_id: GO:0051605 def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] subset: goslim_chembl synonym: "peptidolysis during protein maturation" RELATED [GOC:mah] synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf] synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah] synonym: "protein maturation by proteolysis" RELATED [GOC:mah] is_a: GO:0006508 ! proteolysis is_a: GO:0051604 ! protein maturation [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1 xref: Reactome:REACT_102858 "Diiodinated tyrosine can be deiodinated, Mus musculus" xref: Reactome:REACT_102973 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Canis familiaris" xref: Reactome:REACT_103874 "Monoiodinated tyrosine can be deiodinated, Canis familiaris" xref: Reactome:REACT_104604 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Danio rerio" xref: Reactome:REACT_105062 "Monoiodinated tyrosine can be deiodinated, Danio rerio" xref: Reactome:REACT_105121 "Monoiodinated tyrosine can be deiodinated, Caenorhabditis elegans" xref: Reactome:REACT_106088 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Rattus norvegicus" xref: Reactome:REACT_106276 "Monoiodinated tyrosine can be deiodinated, Rattus norvegicus" xref: Reactome:REACT_107002 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Sus scrofa" xref: Reactome:REACT_107467 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Rattus norvegicus" xref: Reactome:REACT_108745 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Taeniopygia guttata" xref: Reactome:REACT_109500 "Monoiodinated tyrosine can be deiodinated, Bos taurus" xref: Reactome:REACT_110582 "Diiodinated tyrosine can be deiodinated, Rattus norvegicus" xref: Reactome:REACT_115316 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Drosophila melanogaster" xref: Reactome:REACT_15389 "Monoiodinated tyrosine can be deiodinated, Homo sapiens" xref: Reactome:REACT_15410 "Diiodinated tyrosine can be deiodinated, Homo sapiens" xref: Reactome:REACT_17006 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Homo sapiens" xref: Reactome:REACT_17042 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Homo sapiens" xref: Reactome:REACT_29212 "Diiodinated tyrosine can be deiodinated, Canis familiaris" xref: Reactome:REACT_30160 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Mus musculus" xref: Reactome:REACT_31762 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Gallus gallus" xref: Reactome:REACT_32960 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Bos taurus" xref: Reactome:REACT_34705 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Mus musculus" xref: Reactome:REACT_44470 "Monoiodinated tyrosine can be deiodinated, Mus musculus" xref: Reactome:REACT_78923 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Taeniopygia guttata" xref: Reactome:REACT_84842 "Diiodinated tyrosine can be deiodinated, Gallus gallus" xref: Reactome:REACT_86178 "Monoiodinated tyrosine can be deiodinated, Xenopus tropicalis" xref: Reactome:REACT_88304 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Bos taurus" xref: Reactome:REACT_89057 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Gallus gallus" xref: Reactome:REACT_90394 "Diiodinated tyrosine can be deiodinated, Xenopus tropicalis" xref: Reactome:REACT_91638 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Arabidopsis thaliana" xref: Reactome:REACT_91952 "Monoiodinated tyrosine can be deiodinated, Gallus gallus" xref: Reactome:REACT_92075 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Xenopus tropicalis" xref: Reactome:REACT_92434 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Canis familiaris" xref: Reactome:REACT_93539 "Diiodinated tyrosine can be deiodinated, Drosophila melanogaster" xref: Reactome:REACT_93974 "Diiodinated tyrosine can be deiodinated, Taeniopygia guttata" xref: Reactome:REACT_95169 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Danio rerio" xref: Reactome:REACT_95558 "Monoiodinated tyrosine can be deiodinated, Sus scrofa" xref: Reactome:REACT_95573 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Caenorhabditis elegans" xref: Reactome:REACT_97234 "Diiodinated tyrosine can be deiodinated, Caenorhabditis elegans" xref: Reactome:REACT_97568 "Diiodinated tyrosine can be deiodinated, Sus scrofa" xref: Reactome:REACT_97851 "Diiodinated tyrosine can be deiodinated, Bos taurus" xref: Reactome:REACT_98022 "Monoiodinated tyrosine can be deiodinated, Drosophila melanogaster" xref: Reactome:REACT_99085 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Oryza sativa" xref: Reactome:REACT_99794 "Diiodinated tyrosine can be deiodinated, Danio rerio" xref: Reactome:REACT_99989 "Monoiodinated tyrosine can be deiodinated, Taeniopygia guttata" is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0016540 name: protein autoprocessing namespace: biological_process def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337] subset: goslim_chembl is_a: GO:0016485 ! protein processing [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:2 xref: Reactome:REACT_25050 "Molybdenum ion transfer onto molybdopterin, Homo sapiens" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016746 name: transferase activity, transferring acyl groups namespace: molecular_function alt_id: GO:0008415 def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic synonym: "acyltransferase activity" EXACT [] xref: EC:2.3 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016757 name: transferase activity, transferring glycosyl groups namespace: molecular_function alt_id: GO:0016932 def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term. subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "glycosyltransferase activity" EXACT [] synonym: "transferase activity, transferring other glycosyl groups" NARROW [] synonym: "transglycosidase activity" EXACT [] synonym: "transglycosylase activity" EXACT [] xref: EC:2.4 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016765 name: transferase activity, transferring alkyl or aryl (other than methyl) groups namespace: molecular_function alt_id: GO:0016766 def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] xref: EC:2.5 xref: EC:2.5.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl xref: EC:2.7 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast xref: EC:2.7.7 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:3 xref: Reactome:REACT_110436 "Hydrolysis of phosphatidylcholine, Bos taurus" xref: Reactome:REACT_111159 "Partial proteolysis of antigen in phagolysosomes, Homo sapiens" xref: Reactome:REACT_15331 "Hydrolysis of phosphatidylcholine, Homo sapiens" xref: Reactome:REACT_83734 "Hydrolysis of phosphatidylcholine, Danio rerio" xref: Reactome:REACT_84047 "Hydrolysis of phosphatidylcholine, Xenopus tropicalis" xref: Reactome:REACT_87959 "Hydrolysis of phosphatidylcholine, Gallus gallus" xref: Reactome:REACT_88159 "Hydrolysis of phosphatidylcholine, Canis familiaris" xref: Reactome:REACT_90118 "Hydrolysis of phosphatidylcholine, Mus musculus" xref: Reactome:REACT_91045 "Hydrolysis of phosphatidylcholine, Taeniopygia guttata" xref: Reactome:REACT_98572 "Hydrolysis of phosphatidylcholine, Rattus norvegicus" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016788 name: hydrolase activity, acting on ester bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] subset: goslim_chembl synonym: "esterase activity" EXACT [] xref: EC:3.1 xref: Reactome:REACT_106563 "Deacylation of Acyl Ghrelin, Mus musculus" xref: Reactome:REACT_109748 "Deacylation of Acyl Ghrelin, Bos taurus" xref: Reactome:REACT_112177 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Xenopus tropicalis" xref: Reactome:REACT_19294 "Deacylation of Acyl Ghrelin, Homo sapiens" xref: Reactome:REACT_1978 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Homo sapiens" xref: Reactome:REACT_45174 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Mus musculus" xref: Reactome:REACT_77112 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Danio rerio" xref: Reactome:REACT_81282 "Deacylation of Acyl Ghrelin, Rattus norvegicus" xref: Reactome:REACT_83347 "Deacylation of Acyl Ghrelin, Gallus gallus" xref: Reactome:REACT_88228 "Deacylation of Acyl Ghrelin, Canis familiaris" xref: Reactome:REACT_88314 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Sus scrofa" xref: Reactome:REACT_89615 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Rattus norvegicus" xref: Reactome:REACT_92446 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Canis familiaris" xref: Reactome:REACT_94475 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Bos taurus" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016791 name: phosphatase activity namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "4-nitrophenylphosphatase activity" NARROW [] synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "NPPase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] synonym: "PNPPase activity" NARROW [EC:3.1.3.41] xref: EC:3.1.3 xref: EC:3.1.3.41 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: RHEA:21664 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0016798 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "glycosidase activity" EXACT [] synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016810 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term. subset: goslim_chembl subset: goslim_generic synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] xref: EC:3.5 xref: Reactome:REACT_27208 "acetylglucosamine-inositol is deacetylated by Mca, Mycobacterium tuberculosis" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "other lyase activity" NARROW [] xref: EC:4 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "other isomerase activity" NARROW [] xref: EC:5 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6 xref: Reactome:REACT_115603 "Ligation of DNA at sites of patch replacement, Gallus gallus" xref: Reactome:REACT_116018 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Gallus gallus" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016887 name: ATPase activity namespace: molecular_function alt_id: GO:0004002 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3] synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3] synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3] synonym: "ATP phosphohydrolase activity" EXACT [] synonym: "complex V (mitochondrial electron transport)" RELATED [EC:3.6.1.3] synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3] synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3] xref: EC:3.6.1.3 xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN xref: Reactome:REACT_100141 "Trafficking of GluR2-containing AMPA receptors to synapse, Canis familiaris" xref: Reactome:REACT_108873 "Trafficking of GluR2-containing AMPA receptors to synapse, Bos taurus" xref: Reactome:REACT_110992 "Trafficking of GluR2-containing AMPA receptors to synapse, Danio rerio" xref: Reactome:REACT_113271 "Trafficking of GluR2-containing AMPA receptors to synapse, Xenopus tropicalis" xref: Reactome:REACT_18320 "Trafficking of GluR2-containing AMPA receptors to synapse, Homo sapiens" xref: Reactome:REACT_27184 "ESCRT Disassembly, Homo sapiens" xref: Reactome:REACT_33329 "Trafficking of GluR2-containing AMPA receptors to synapse, Gallus gallus" xref: Reactome:REACT_79964 "Trafficking of GluR2-containing AMPA receptors to synapse, Mus musculus" xref: Reactome:REACT_84196 "Trafficking of GluR2-containing AMPA receptors to synapse, Drosophila melanogaster" xref: Reactome:REACT_87020 "Trafficking of GluR2-containing AMPA receptors to synapse, Rattus norvegicus" xref: Reactome:REACT_89934 "Trafficking of GluR2-containing AMPA receptors to synapse, Taeniopygia guttata" xref: RHEA:13065 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0016936 name: galactoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose." [CHEBI:24163, GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0003674 ! molecular_function [Term] id: GO:0017111 name: nucleoside-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] subset: goslim_chembl subset: goslim_metagenomics synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" EXACT [] synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: RHEA:23680 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0017144 name: drug metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2] subset: goslim_chembl subset: goslim_pir synonym: "drug metabolism" EXACT [] xref: Reactome:REACT_100188 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Danio rerio" xref: Reactome:REACT_106588 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Canis familiaris" xref: Reactome:REACT_109592 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Taeniopygia guttata" xref: Reactome:REACT_110347 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Gallus gallus" xref: Reactome:REACT_163 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Homo sapiens" xref: Reactome:REACT_54870 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Bos taurus" xref: Reactome:REACT_85142 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Mus musculus" xref: Reactome:REACT_88376 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Rattus norvegicus" xref: Reactome:REACT_92052 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI), Sus scrofa" xref: Wikipedia:Drug_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0017147 name: Wnt-protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0018738 name: S-formylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14961] subset: goslim_chembl xref: EC:3.1.2.12 xref: KEGG:R00527 xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN xref: RHEA:14961 xref: UM-BBD_reactionID:r0241 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0019012 name: virion namespace: cellular_component def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "complete virus particle" EXACT [] xref: Wikipedia:Virus is_a: GO:0005575 ! cellular_component [Term] id: GO:0019013 name: viral nucleocapsid namespace: cellular_component alt_id: GO:0019014 def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] subset: goslim_chembl synonym: "core" BROAD [] synonym: "nucleocapsid" EXACT [] is_a: GO:0005575 ! cellular_component relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0019028 name: viral capsid namespace: cellular_component alt_id: GO:0046728 def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_chembl xref: Wikipedia:Capsid is_a: GO:0005575 ! cellular_component relationship: part_of GO:0019012 ! virion [Term] id: GO:0019031 name: viral envelope namespace: cellular_component def: "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] subset: goslim_chembl synonym: "viral glycoprotein" RELATED [] synonym: "viral outside membrane" EXACT [] xref: Wikipedia:Viral_envelope is_a: GO:0005575 ! cellular_component relationship: part_of GO:0019012 ! virion [Term] id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "secondary metabolism" EXACT [] synonym: "secondary metabolite metabolic process" EXACT [] synonym: "secondary metabolite metabolism" EXACT [] xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0019835 name: cytolysis namespace: biological_process def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] subset: goslim_chembl synonym: "autolysin activity" RELATED [] synonym: "bacteriocin activity" RELATED [] synonym: "bacteriolytic toxin activity" RELATED [] synonym: "holin" RELATED [] synonym: "lysin activity" RELATED [] synonym: "lysis" BROAD [] synonym: "necrosis" RELATED [] xref: Wikipedia:Cytolysis is_a: GO:0008150 ! biological_process [Term] id: GO:0019838 name: growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators] subset: goslim_chembl synonym: "neurotrophin TRK receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019843 name: rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast is_a: GO:0003723 ! RNA binding [Term] id: GO:0019864 name: IgG binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149] subset: goslim_chembl is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0019899 name: enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with any enzyme." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0019904 name: protein domain specific binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators] subset: goslim_chembl synonym: "protein domain-specific binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. subset: goslim_chembl subset: goslim_generic is_a: GO:0008150 ! biological_process [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0022618 name: ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic synonym: "protein-RNA complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function alt_id: GO:0005386 alt_id: GO:0015563 alt_id: GO:0015646 alt_id: GO:0022891 alt_id: GO:0022892 def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "substrate-specific transmembrane transporter activity" RELATED [] synonym: "substrate-specific transporter activity" NARROW [] synonym: "uptake permease activity" RELATED [] synonym: "uptake transmembrane transporter activity" RELATED [] xref: Reactome:REACT_100033 "GLUT9 transports glucose, fructose and urate, Gallus gallus" xref: Reactome:REACT_106735 "GLUT9 transports glucose, fructose and urate, Xenopus tropicalis" xref: Reactome:REACT_111088 "Egress of internalized antigen to the cytosol via sec61, Homo sapiens" xref: Reactome:REACT_111933 "GLUT9 transports glucose, fructose and urate, Plasmodium falciparum" xref: Reactome:REACT_113047 "GLUT9 transports glucose, fructose and urate, Dictyostelium discoideum" xref: Reactome:REACT_113116 "GLUT9 transports glucose, fructose and urate, Mycobacterium tuberculosis" xref: Reactome:REACT_113829 "GLUT9 transports glucose, fructose and urate, Arabidopsis thaliana" xref: Reactome:REACT_114161 "GLUT9 transports glucose, fructose and urate, Oryza sativa" xref: Reactome:REACT_19288 "GLUT9 transports glucose, fructose and urate, Homo sapiens" xref: Reactome:REACT_77235 "GLUT9 transports glucose, fructose and urate, Canis familiaris" xref: Reactome:REACT_81225 "GLUT9 transports glucose, fructose and urate, Bos taurus" xref: Reactome:REACT_88503 "GLUT9 transports glucose, fructose and urate, Taeniopygia guttata" xref: Reactome:REACT_91849 "GLUT9 transports glucose, fructose and urate, Mus musculus" xref: Reactome:REACT_94185 "GLUT9 transports glucose, fructose and urate, Rattus norvegicus" is_a: GO:0005215 ! transporter activity relationship: part_of GO:0055085 ! transmembrane transport [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: Wikipedia:Cellular_differentiation is_a: GO:0008150 ! biological_process [Term] id: GO:0030169 name: low-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah] subset: goslim_chembl synonym: "LDL binding" EXACT [] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "extracellular matrix organisation" EXACT [GOC:curators] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0030234 name: enzyme regulator activity namespace: molecular_function alt_id: GO:0010576 def: "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] comment: GO:0030234 is reserved for cases when the regulator directly interacts with the enzyme. When regulation of enzyme activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'regulation of catalytic activity ; GO:0050790'. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "catalytic regulator activity" EXACT [GOC:dph] synonym: "enzyme modulator" EXACT [] synonym: "metalloenzyme regulator activity" NARROW [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0050790 ! regulation of catalytic activity relationship: regulates GO:0003824 ! catalytic activity [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function alt_id: GO:0005529 def: "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators] comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005623 ! cell [Term] id: GO:0030533 name: triplet codon-amino acid adaptor activity namespace: molecular_function def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732] comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "transfer RNA" RELATED [] synonym: "tRNA" RELATED [] is_a: GO:0003723 ! RNA binding relationship: part_of GO:0006412 ! translation [Term] id: GO:0030554 name: adenyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0030674 name: protein binding, bridging namespace: molecular_function def: "The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "protein-protein adaptor" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_generic is_a: GO:0006810 ! transport relationship: occurs_in GO:0005622 ! intracellular relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0030881 name: beta-2-microglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-2-microglobulin." [GOC:mah] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component alt_id: GO:0005578 def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "proteinaceous extracellular matrix" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090513 xref: Wikipedia:Extracellular_matrix is_a: GO:0005575 ! cellular_component relationship: part_of GO:0005576 ! extracellular region [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0043226 ! organelle relationship: part_of GO:0005737 ! cytoplasm [Term] id: GO:0031638 name: zymogen activation namespace: biological_process def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] subset: goslim_chembl synonym: "zymogen activation by proteolytic cleavage" EXACT [] is_a: GO:0016485 ! protein processing [Term] id: GO:0031639 name: plasminogen activation namespace: biological_process def: "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [PMID:9548733] subset: goslim_chembl synonym: "cleavage of plasminogen to plasmin" EXACT [] is_a: GO:0031638 ! zymogen activation [Term] id: GO:0031994 name: insulin-like growth factor I binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin-like growth factor I." [GOC:mah] subset: goslim_chembl synonym: "IGF-I binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0031995 name: insulin-like growth factor II binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin-like growth factor II." [GOC:mah] subset: goslim_chembl synonym: "IGF-II binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0032182 name: ubiquitin-like protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "small conjugating protein binding" EXACT [GOC:dph] is_a: GO:0005515 ! protein binding [Term] id: GO:0032196 name: transposition namespace: biological_process def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast xref: Wikipedia:Transposon is_a: GO:0008150 ! biological_process [Term] id: GO:0032259 name: methylation namespace: biological_process def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] subset: goslim_chembl xref: Reactome:REACT_100463 "Methylation, Rattus norvegicus" xref: Reactome:REACT_104378 "Methylation, Staphylococcus aureus N315" xref: Reactome:REACT_106986 "Methylation, Schizosaccharomyces pombe" xref: Reactome:REACT_107353 "Methylation, Taeniopygia guttata" xref: Reactome:REACT_107808 "Methylation, Caenorhabditis elegans" xref: Reactome:REACT_110691 "Methylation, Gallus gallus" xref: Reactome:REACT_34638 "Methylation, Mus musculus" xref: Reactome:REACT_6946 "Methylation, Homo sapiens" xref: Reactome:REACT_77304 "Methylation, Oryza sativa" xref: Reactome:REACT_78116 "Methylation, Xenopus tropicalis" xref: Reactome:REACT_87183 "Methylation, Drosophila melanogaster" xref: Reactome:REACT_88148 "Methylation, Canis familiaris" xref: Reactome:REACT_90436 "Methylation, Danio rerio" xref: Reactome:REACT_92149 "Methylation, Sus scrofa" xref: Reactome:REACT_92596 "Methylation, Escherichia coli" xref: Reactome:REACT_93357 "Methylation, Mycobacterium tuberculosis" xref: Reactome:REACT_95391 "Methylation, Saccharomyces cerevisiae" xref: Reactome:REACT_98332 "Methylation, Arabidopsis thaliana" xref: Reactome:REACT_99471 "Methylation, Bos taurus" xref: Reactome:REACT_99529 "Methylation, Dictyostelium discoideum" xref: Wikipedia:Methylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component [Term] id: GO:0033961 name: cis-stilbene-oxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol." [EC:3.3.2.9] subset: goslim_chembl synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "benzo(a)pyrene-4,5-epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "benzo[a]pyrene-4,5-oxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "cis-epoxide hydrolase activity" EXACT [EC:3.3.2.9] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.9] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.9] synonym: "mEH" RELATED [EC:3.3.2.9] synonym: "microsomal epoxide hydrase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydratase activity" NARROW [EC:3.3.2.9] synonym: "microsomal epoxide hydrolase activity" NARROW [EC:3.3.2.9] xref: EC:3.3.2.9 xref: MetaCyc:3.3.2.9-RXN xref: RHEA:23900 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0034330 name: cell junction organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cell junction assembly and maintenance" EXACT [] synonym: "cell junction biogenesis" RELATED [] synonym: "cell junction organisation" EXACT [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cellular nitrogen compound metabolism" EXACT [] xref: Reactome:REACT_102000 "Metabolism of amino acids and derivatives, Mycobacterium tuberculosis" xref: Reactome:REACT_103710 "Metabolism of amino acids and derivatives, Escherichia coli" xref: Reactome:REACT_107293 "Metabolism of amino acids and derivatives, Arabidopsis thaliana" xref: Reactome:REACT_108179 "Metabolism of amino acids and derivatives, Xenopus tropicalis" xref: Reactome:REACT_109042 "Metabolism of amino acids and derivatives, Sus scrofa" xref: Reactome:REACT_13 "Metabolism of amino acids and derivatives, Homo sapiens" xref: Reactome:REACT_28699 "Metabolism of amino acids and derivatives, Saccharomyces cerevisiae" xref: Reactome:REACT_29108 "Metabolism of amino acids and derivatives, Caenorhabditis elegans" xref: Reactome:REACT_32429 "Metabolism of amino acids and derivatives, Rattus norvegicus" xref: Reactome:REACT_33347 "Metabolism of amino acids and derivatives, Mus musculus" xref: Reactome:REACT_34326 "Metabolism of amino acids and derivatives, Staphylococcus aureus N315" xref: Reactome:REACT_55564 "Metabolism of amino acids and derivatives, Gallus gallus" xref: Reactome:REACT_77741 "Metabolism of amino acids and derivatives, Taeniopygia guttata" xref: Reactome:REACT_82379 "Metabolism of amino acids and derivatives, Bos taurus" xref: Reactome:REACT_86268 "Metabolism of amino acids and derivatives, Drosophila melanogaster" xref: Reactome:REACT_90299 "Metabolism of amino acids and derivatives, Oryza sativa" xref: Reactome:REACT_91959 "Metabolism of amino acids and derivatives, Plasmodium falciparum" xref: Reactome:REACT_93580 "Metabolism of amino acids and derivatives, Danio rerio" xref: Reactome:REACT_95666 "Metabolism of amino acids and derivatives, Canis familiaris" xref: Reactome:REACT_98086 "Metabolism of amino acids and derivatives, Dictyostelium discoideum" xref: Reactome:REACT_99241 "Metabolism of amino acids and derivatives, Schizosaccharomyces pombe" is_a: GO:0008152 ! metabolic process [Term] id: GO:0034655 name: nucleobase-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0035254 name: glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glutamate receptor." [GOC:bf] subset: goslim_chembl is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0035634 name: response to stilbenoid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones." [CHEBI:26776, GOC:yaf, Wikipedia:Stilbenoid] subset: goslim_chembl is_a: GO:0008150 ! biological_process created_by: rfoulger creation_date: 2011-01-12T10:37:33Z [Term] id: GO:0035690 name: cellular response to drug namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:sl] subset: goslim_chembl is_a: GO:0008150 ! biological_process created_by: rfoulger creation_date: 2011-02-24T03:37:26Z [Term] id: GO:0038023 name: signaling receptor activity namespace: molecular_function alt_id: GO:0004872 alt_id: GO:0019041 def: "Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling] subset: goslim_agr subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "receptor activity" BROAD [] synonym: "receptor activity involved in signal transduction" EXACT [GOC:bf] is_a: GO:0003674 ! molecular_function created_by: rfoulger creation_date: 2011-08-01T02:45:27Z [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process [Term] id: GO:0040011 name: locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another." [GOC:dgh] subset: goslim_chembl subset: goslim_generic subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0042056 name: chemoattractant activity namespace: molecular_function def: "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "attractant" BROAD [] is_a: GO:0048018 ! receptor ligand activity relationship: part_of GO:0040011 ! locomotion [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma, PMID:26404467, Wikipedia:Ribosome_biogenesis] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "ribosome biogenesis and assembly" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042277 name: peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0003674 ! molecular_function [Term] id: GO:0042393 name: histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "histone-specific chaperone activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042562 name: hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl] subset: goslim_chembl subset: goslim_pir is_a: GO:0003674 ! molecular_function [Term] id: GO:0042592 name: homeostatic process namespace: biological_process alt_id: GO:0032844 alt_id: GO:0032845 alt_id: GO:0032846 def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse synonym: "activation of homeostatic process" NARROW [] synonym: "homeostasis" EXACT [] synonym: "inhibition of homeostatic process" NARROW [] synonym: "negative regulation of homeostatic process" RELATED [] synonym: "positive regulation of homeostatic process" RELATED [] synonym: "regulation of homeostatic process" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0042605 name: peptide antigen binding namespace: molecular_function alt_id: GO:0042606 alt_id: GO:0042607 def: "Interacting selectively and non-covalently with an antigen peptide." [GOC:add, GOC:jl, GOC:rv] comment: Note that this term can be used to describe the binding of a peptide to an MHC molecule. subset: goslim_chembl synonym: "endogenous peptide antigen binding" NARROW [] synonym: "exogenous peptide antigen binding" NARROW [] is_a: GO:0003823 ! antigen binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0042802 name: identical protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with an identical protein or proteins." [GOC:jl] subset: goslim_chembl synonym: "isoform-specific homophilic binding" EXACT [PMID:17889655] synonym: "protein homopolymerization" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0042803 name: protein homodimerization activity namespace: molecular_function def: "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl] subset: goslim_chembl synonym: "dimerization activity" BROAD [] is_a: GO:0042802 ! identical protein binding [Term] id: GO:0042813 name: Wnt-activated receptor activity namespace: molecular_function def: "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators] subset: goslim_chembl synonym: "frizzled receptor activity" RELATED [] synonym: "frizzled-2 receptor activity" RELATED [] synonym: "Wnt receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0038023 ! signaling receptor activity relationship: has_part GO:0017147 ! Wnt-protein binding relationship: part_of GO:0007165 ! signal transduction relationship: part_of GO:0007267 ! cell-cell signaling [Term] id: GO:0043008 name: ATP-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0043065 name: positive regulation of apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis] comment: This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. subset: goslim_chembl synonym: "activation of apoptosis" NARROW [] synonym: "positive regulation of apoptosis" NARROW [] synonym: "pro-apoptosis" RELATED [] synonym: "stimulation of apoptosis" NARROW [] synonym: "up regulation of apoptosis" EXACT [] synonym: "up-regulation of apoptosis" EXACT [] synonym: "upregulation of apoptosis" EXACT [] is_a: GO:0008150 ! biological_process relationship: positively_regulates GO:0008219 ! cell death relationship: regulates GO:0008219 ! cell death [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process alt_id: GO:0048554 def: "Any process that activates or increases the activity of an enzyme." [GOC:ebc, GOC:jl, GOC:tb, GOC:vw] subset: goslim_chembl synonym: "activation of enzyme activity" NARROW [] synonym: "activation of metalloenzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "positive regulation of metalloenzyme activity" NARROW [] synonym: "stimulation of enzyme activity" NARROW [] synonym: "stimulation of metalloenzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up regulation of metalloenzyme activity" NARROW [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "up-regulation of metalloenzyme activity" NARROW [] synonym: "upregulation of enzyme activity" EXACT [] synonym: "upregulation of metalloenzyme activity" NARROW [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0008150 ! biological_process intersection_of: positively_regulates GO:0003824 ! catalytic activity relationship: positively_regulates GO:0003824 ! catalytic activity [Term] id: GO:0043167 name: ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with ions, charged atoms or groups of atoms." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "atom binding" RELATED [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0005575 ! cellular_component [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0043621 name: protein self-association namespace: molecular_function def: "Interacting selectively and non-covalently with a domain within the same polypeptide." [GOC:jl] subset: goslim_chembl synonym: "intramolecular protein binding" EXACT [] synonym: "protein self association" EXACT [] synonym: "protein self binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0044179 name: hemolysis in other organism namespace: biological_process def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl] subset: goslim_chembl synonym: "hemolysis of cells in other organism" EXACT [GOC:bf] synonym: "hemolysis of erythrocytes in other organism" EXACT [] synonym: "hemolysis of RBCs in other organism" EXACT [] synonym: "hemolysis of red blood cells in other organism" EXACT [] is_a: GO:0019835 ! cytolysis created_by: jane creation_date: 2009-09-04T03:36:00Z [Term] id: GO:0044183 name: protein binding involved in protein folding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding." [GOC:mtg_cambridge_2009] subset: goslim_chembl synonym: "chaperone activity" BROAD [] is_a: GO:0005515 ! protein binding intersection_of: GO:0005515 ! protein binding intersection_of: part_of GO:0006457 ! protein folding relationship: part_of GO:0006457 ! protein folding created_by: jane creation_date: 2009-09-25T11:33:48Z [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] xref: Reactome:REACT_111217 "Metabolism, Homo sapiens" xref: Reactome:REACT_112077 "Metabolism, Xenopus tropicalis" xref: Reactome:REACT_112140 "Metabolism, Dictyostelium discoideum" xref: Reactome:REACT_112621 "Metabolism, Mus musculus" xref: Reactome:REACT_112912 "Metabolism, Arabidopsis thaliana" xref: Reactome:REACT_113131 "Metabolism, Schizosaccharomyces pombe" xref: Reactome:REACT_113305 "Metabolism, Canis familiaris" xref: Reactome:REACT_113457 "Metabolism, Mycobacterium tuberculosis" xref: Reactome:REACT_113568 "Metabolism, Rattus norvegicus" xref: Reactome:REACT_113610 "Metabolism, Caenorhabditis elegans" xref: Reactome:REACT_113934 "Metabolism, Escherichia coli" xref: Reactome:REACT_114081 "Metabolism, Gallus gallus" xref: Reactome:REACT_114137 "Metabolism, Sus scrofa" xref: Reactome:REACT_114421 "Metabolism, Saccharomyces cerevisiae" xref: Reactome:REACT_114473 "Metabolism, Danio rerio" xref: Reactome:REACT_114495 "Metabolism, Staphylococcus aureus N315" xref: Reactome:REACT_114668 "Metabolism, Plasmodium falciparum" xref: Reactome:REACT_114983 "Metabolism, Drosophila melanogaster" xref: Reactome:REACT_115063 "Metabolism, Taeniopygia guttata" xref: Reactome:REACT_115388 "Metabolism, Oryza sativa" xref: Reactome:REACT_115420 "Metabolism, Bos taurus" xref: Reactome:REACT_115655 "Metabolism, Gallus gallus" is_a: GO:0008152 ! metabolic process created_by: jane creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044325 name: ion channel binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:BHF, GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding created_by: janelomax creation_date: 2010-08-04T12:52:59Z [Term] id: GO:0044403 name: symbiont process namespace: biological_process alt_id: GO:0043298 alt_id: GO:0044404 alt_id: GO:0072519 alt_id: GO:0085031 def: "A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts." [GOC:cc, https://study.com/academy/lesson/symbiont-definition-lesson-quiz.html] comment: Changed term, definition see https://github.com/geneontology/go-ontology/issues/14807 subset: goslim_chembl subset: goslim_generic synonym: "commensalism" NARROW [] synonym: "host-pathogen interaction" NARROW [] synonym: "parasitism" NARROW [] synonym: "symbiosis" RELATED [] synonym: "symbiosis, encompassing mutualism through parasitism" RELATED [] synonym: "symbiotic interaction" RELATED [] synonym: "symbiotic interaction between host and organism" RELATED [] synonym: "symbiotic interaction between organisms" RELATED [] synonym: "symbiotic interaction between species" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0044877 name: protein-containing complex binding namespace: molecular_function alt_id: GO:0032403 def: "Interacting selectively and non-covalently with a macromolecular complex." [GOC:jl] subset: goslim_chembl synonym: "macromolecular complex binding" RELATED [] synonym: "protein complex binding" EXACT [] is_a: GO:0003674 ! molecular_function created_by: janelomax creation_date: 2014-12-16T11:38:58Z [Term] id: GO:0045569 name: TRAIL binding namespace: molecular_function def: "Interacting selectively and non-covalently with TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines." [GOC:go_curators, PMID:9082980] subset: goslim_chembl synonym: "Apo-2L binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0046677 name: response to antibiotic namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms." [GOC:ai, GOC:ef] subset: goslim_chembl synonym: "antibiotic susceptibility/resistance" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0046789 name: host cell surface receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor on the host cell surface." [GOC:ai, PMID:11511370] subset: goslim_chembl synonym: "cell surface antigen activity, host-interacting" RELATED [] synonym: "cell surface receptor ligand" RELATED [] is_a: GO:0003674 ! molecular_function relationship: part_of GO:0044403 ! symbiont process [Term] id: GO:0046982 name: protein heterodimerization activity namespace: molecular_function def: "Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer." [GOC:ai] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0047372 name: acylglycerol lipase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol." [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] subset: goslim_chembl synonym: "fatty acyl monoester lipase activity" EXACT [EC:3.1.1.23] synonym: "glycerol-ester acylhydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerol hydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerol lipase activity" EXACT [EC:3.1.1.23] synonym: "monoacylglycerolipase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceridase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceride hydrolase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceride lipase activity" EXACT [EC:3.1.1.23] synonym: "monoglyceridyllipase activity" EXACT [EC:3.1.1.23] xref: EC:3.1.1.23 xref: MetaCyc:3.1.1.23-RXN xref: Reactome:REACT_100140 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Gallus gallus" xref: Reactome:REACT_100448 "Digestion of diacylglycerols by extracellular PTL:colipase, Taeniopygia guttata" xref: Reactome:REACT_100782 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Bos taurus" xref: Reactome:REACT_101036 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Danio rerio" xref: Reactome:REACT_102360 "2-acylglycerol + H2O -> glycerol + fatty acid, Canis familiaris" xref: Reactome:REACT_103536 "2-AG hydrolysis to arachidonate by MAGL, Schizosaccharomyces pombe" xref: Reactome:REACT_103689 "Digestion of diacylglycerols by extracellular PTL:colipase, Mus musculus" xref: Reactome:REACT_104272 "2-acylglycerol + H2O -> glycerol + fatty acid, Dictyostelium discoideum" xref: Reactome:REACT_104481 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Rattus norvegicus" xref: Reactome:REACT_105008 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Rattus norvegicus" xref: Reactome:REACT_106113 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Mus musculus" xref: Reactome:REACT_106352 "2-AG hydrolysis to arachidonate by MAGL, Xenopus tropicalis" xref: Reactome:REACT_106907 "2-AG hydrolysis to arachidonate by MAGL, Gallus gallus" xref: Reactome:REACT_107190 "2-acylglycerol + H2O -> glycerol + fatty acid, Mycobacterium tuberculosis" xref: Reactome:REACT_107266 "Digestion of triacylglycerols by extracellular PTL:colipase, Bos taurus" xref: Reactome:REACT_107746 "2-AG hydrolysis to arachidonate by MAGL, Rattus norvegicus" xref: Reactome:REACT_107847 "Digestion of diacylglycerols by extracellular PTL:colipase, Canis familiaris" xref: Reactome:REACT_107870 "DAG is metabolized by DAGL to 2-AG, Mus musculus" xref: Reactome:REACT_108459 "DAG is metabolized by DAGL to 2-AG, Bos taurus" xref: Reactome:REACT_108633 "Digestion of diacylglycerols by extracellular PTL:colipase, Rattus norvegicus" xref: Reactome:REACT_109762 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Danio rerio" xref: Reactome:REACT_109931 "2-AG hydrolysis to arachidonate by MAGL, Saccharomyces cerevisiae" xref: Reactome:REACT_112247 "Digestion of diacylglycerols by extracellular PTL:colipase, Xenopus tropicalis" xref: Reactome:REACT_112520 "DAG is metabolized by DAGL to 2-AG, Arabidopsis thaliana" xref: Reactome:REACT_112608 "2-AG hydrolysis to arachidonate by MAGL, Arabidopsis thaliana" xref: Reactome:REACT_112674 "DAG is metabolized by DAGL to 2-AG, Oryza sativa" xref: Reactome:REACT_113210 "Digestion of triacylglycerols by extracellular PTL:colipase, Gallus gallus" xref: Reactome:REACT_113735 "2-acylglycerol + H2O -> glycerol + fatty acid, Arabidopsis thaliana" xref: Reactome:REACT_114438 "2-acylglycerol + H2O -> glycerol + fatty acid, Staphylococcus aureus N315" xref: Reactome:REACT_114496 "Digestion of triacylglycerols by extracellular PTL:colipase, Xenopus tropicalis" xref: Reactome:REACT_114762 "Digestion of diacylglycerols by extracellular PTL:colipase, Gallus gallus" xref: Reactome:REACT_114842 "2-acylglycerol + H2O -> glycerol + fatty acid, Oryza sativa" xref: Reactome:REACT_115057 "2-AG hydrolysis to arachidonate by MAGL, Staphylococcus aureus N315" xref: Reactome:REACT_115200 "2-AG hydrolysis to arachidonate by MAGL, Oryza sativa" xref: Reactome:REACT_115325 "DAG is metabolized by DAGL to 2-AG, Caenorhabditis elegans" xref: Reactome:REACT_19135 "DAG is metabolized by DAGL to 2-AG, Homo sapiens" xref: Reactome:REACT_19155 "2-AG hydrolysis to arachidonate by MAGL, Homo sapiens" xref: Reactome:REACT_2017 "2-acylglycerol + H2O -> glycerol + fatty acid, Rattus norvegicus" xref: Reactome:REACT_28317 "DAG is metabolized by DAGL to 2-AG, Canis familiaris" xref: Reactome:REACT_28378 "Digestion of triacylglycerols by extracellular PTL:colipase, Taeniopygia guttata" xref: Reactome:REACT_28451 "2-AG hydrolysis to arachidonate by MAGL, Bos taurus" xref: Reactome:REACT_29329 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Bos taurus" xref: Reactome:REACT_30437 "Digestion of triacylglycerols by extracellular PTL:colipase, Mus musculus" xref: Reactome:REACT_30947 "Digestion of triacylglycerols by extracellular PTL:colipase, Canis familiaris" xref: Reactome:REACT_31803 "2-AG hydrolysis to arachidonate by MAGL, Danio rerio" xref: Reactome:REACT_31882 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Canis familiaris" xref: Reactome:REACT_33472 "2-acylglycerol + H2O -> glycerol + fatty acid, Xenopus tropicalis" xref: Reactome:REACT_33717 "DAG is metabolized by DAGL to 2-AG, Drosophila melanogaster" xref: Reactome:REACT_33722 "Digestion of diacylglycerols by extracellular PTL:colipase, Sus scrofa" xref: Reactome:REACT_34461 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Mus musculus" xref: Reactome:REACT_594 "2-acylglycerol + H2O -> glycerol + fatty acid, Homo sapiens" xref: Reactome:REACT_77077 "2-AG hydrolysis to arachidonate by MAGL, Taeniopygia guttata" xref: Reactome:REACT_78957 "2-acylglycerol + H2O -> glycerol + fatty acid, Mus musculus" xref: Reactome:REACT_79441 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Taeniopygia guttata" xref: Reactome:REACT_79543 "2-acylglycerol + H2O -> glycerol + fatty acid, Taeniopygia guttata" xref: Reactome:REACT_81812 "2-AG hydrolysis to arachidonate by MAGL, Dictyostelium discoideum" xref: Reactome:REACT_81944 "Digestion of triacylglycerols by extracellular PTL:colipase, Rattus norvegicus" xref: Reactome:REACT_82735 "DAG is metabolized by DAGL to 2-AG, Rattus norvegicus" xref: Reactome:REACT_83703 "2-acylglycerol + H2O -> glycerol + fatty acid, Danio rerio" xref: Reactome:REACT_85221 "DAG is metabolized by DAGL to 2-AG, Gallus gallus" xref: Reactome:REACT_85539 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Gallus gallus" xref: Reactome:REACT_87188 "Digestion of triacylglycerols by extracellular PTL:colipase, Sus scrofa" xref: Reactome:REACT_87496 "DAG is metabolized by DAGL to 2-AG, Sus scrofa" xref: Reactome:REACT_88280 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Xenopus tropicalis" xref: Reactome:REACT_90857 "2-acylglycerol + H2O -> glycerol + fatty acid, Schizosaccharomyces pombe" xref: Reactome:REACT_91226 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Taeniopygia guttata" xref: Reactome:REACT_92458 "DAG is metabolized by DAGL to 2-AG, Xenopus tropicalis" xref: Reactome:REACT_92811 "DAG is metabolized by DAGL to 2-AG, Danio rerio" xref: Reactome:REACT_9389 "Digestion of triacylglycerols by extracellular pancreatic lipase-related protein 2, Homo sapiens" xref: Reactome:REACT_9412 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Homo sapiens" xref: Reactome:REACT_94131 "2-acylglycerol + H2O -> glycerol + fatty acid, Saccharomyces cerevisiae" xref: Reactome:REACT_9457 "Digestion of diacylglycerols by extracellular PTL:colipase, Homo sapiens" xref: Reactome:REACT_9501 "Digestion of triacylglycerols by extracellular PTL:colipase, Homo sapiens" xref: Reactome:REACT_9502 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Homo sapiens" xref: Reactome:REACT_96506 "Digestion of monoacylglycerols by extracellular CEL (bile salt-dependent lipase), Xenopus tropicalis" xref: Reactome:REACT_97548 "DAG is metabolized by DAGL to 2-AG, Taeniopygia guttata" xref: Reactome:REACT_97648 "Digestion of triacylglycerols by extracellular CEL (bile salt-dependent lipase), Canis familiaris" xref: Reactome:REACT_97903 "2-AG hydrolysis to arachidonate by MAGL, Mus musculus" xref: Reactome:REACT_98049 "2-acylglycerol + H2O -> glycerol + fatty acid, Bos taurus" xref: Reactome:REACT_98154 "2-AG hydrolysis to arachidonate by MAGL, Mycobacterium tuberculosis" xref: Reactome:REACT_98390 "2-acylglycerol + H2O -> glycerol + fatty acid, Gallus gallus" xref: Reactome:REACT_99097 "2-AG hydrolysis to arachidonate by MAGL, Canis familiaris" xref: Reactome:REACT_99807 "Digestion of diacylglycerols by extracellular PTL:colipase, Bos taurus" is_a: GO:0016298 ! lipase activity [Term] id: GO:0047499 name: calcium-independent phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+." [EC:3.1.1.4] subset: goslim_chembl synonym: "calcium-independent cytosolic phospholipase A2 activity" NARROW [] is_a: GO:0004623 ! phospholipase A2 activity [Term] id: GO:0047704 name: bile-salt sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate." [EC:2.8.2.14, MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "BAST I activity" NARROW [EC:2.8.2.14] synonym: "bile acid sulfotransferase I activity" NARROW [EC:2.8.2.14] synonym: "bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity" EXACT [EC:2.8.2.14] synonym: "bile-salt sulphotransferase activity" EXACT [] synonym: "glycolithocholate sulfotransferase activity" NARROW [EC:2.8.2.14] xref: EC:2.8.2.14 xref: MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0047894 name: flavonol 3-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate." [EC:2.8.2.25, RHEA:13453] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity" EXACT systematic_synonym [EC:2.8.2.25] synonym: "flavonol 3-sulphotransferase activity" EXACT [] xref: EC:2.8.2.25 xref: KEGG:R02159 xref: MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN xref: RHEA:13453 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0048018 name: receptor ligand activity namespace: molecular_function alt_id: GO:0071884 def: "The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands)." [GOC:kv, GOC:molecular_function_refactoring, GOC:pdt] comment: Definition discussed in https://github.com/geneontology/go-ontology/issues/14220 subset: goslim_chembl synonym: "receptor agonist activity" BROAD [GOC:molecular_function_refactoring] synonym: "signaling molecule" EXACT [] synonym: "vitamin D receptor activator activity" NARROW [] is_a: GO:0005102 ! signaling receptor binding relationship: part_of GO:0008150 ! biological_process relationship: regulates GO:0038023 ! signaling receptor activity created_by: midori creation_date: 2010-09-13T04:51:59Z [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl subset: goslim_generic synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0008150 ! biological_process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. subset: goslim_chembl subset: goslim_generic synonym: "development of an anatomical structure" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0048870 name: cell motility namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg] subset: goslim_chembl subset: goslim_generic synonym: "cell locomotion" EXACT [] synonym: "cell movement" RELATED [] synonym: "movement of a cell" EXACT [] is_a: GO:0040011 ! locomotion relationship: part_of GO:0008150 ! biological_process [Term] id: GO:0050294 name: steroid sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity" EXACT [EC:2.8.2.15] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.15] synonym: "steroid sulphotransferase activity" EXACT [] xref: EC:2.8.2.15 xref: MetaCyc:STEROID-SULFOTRANSFERASE-RXN xref: Reactome:REACT_100713 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_101023 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_101639 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Canis familiaris" xref: Reactome:REACT_102701 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Gallus gallus" xref: Reactome:REACT_104351 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Danio rerio" xref: Reactome:REACT_106171 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Bos taurus" xref: Reactome:REACT_107395 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Gallus gallus" xref: Reactome:REACT_110277 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_112914 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Danio rerio" xref: Reactome:REACT_115144 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Gallus gallus" xref: Reactome:REACT_29849 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_30410 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_6805 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6949 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Homo sapiens" xref: Reactome:REACT_6969 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Homo sapiens" xref: Reactome:REACT_79278 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_80906 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Mus musculus" xref: Reactome:REACT_81388 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Rattus norvegicus" xref: Reactome:REACT_85290 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Canis familiaris" xref: Reactome:REACT_85350 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Taeniopygia guttata" xref: Reactome:REACT_85457 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Mus musculus" xref: Reactome:REACT_87765 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Canis familiaris" xref: Reactome:REACT_89252 "dehydroepiandrosterone (DHEA) + PAPS => DHEA sulfate + PAP, Bos taurus" xref: Reactome:REACT_93059 "pregnenolone + PAPS => pregnenolone sulfate + PAP, Danio rerio" xref: Reactome:REACT_97439 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Mus musculus" xref: Reactome:REACT_98750 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Xenopus tropicalis" xref: Reactome:REACT_99329 "beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP, Bos taurus" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process alt_id: GO:0048552 def: "Any process that modulates the activity of an enzyme." [GOC:ai, GOC:ebc, GOC:vw] subset: goslim_chembl synonym: "regulation of enzyme activity" EXACT [] synonym: "regulation of metalloenzyme activity" NARROW [] is_a: GO:0008150 ! biological_process intersection_of: GO:0008150 ! biological_process intersection_of: regulates GO:0003824 ! catalytic activity relationship: regulates GO:0003824 ! catalytic activity [Term] id: GO:0050821 name: protein stabilization namespace: biological_process def: "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai] subset: goslim_chembl synonym: "lysosomal protein stabilization" NARROW [] synonym: "positive regulation of protein stability" EXACT [] synonym: "protein sequestering" RELATED [] synonym: "protein stabilisation" EXACT [GOC:ah] synonym: "protein stabilization activity" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0050840 name: extracellular matrix binding namespace: molecular_function def: "Interacting selectively and non-covalently with a component of the extracellular matrix." [GOC:ai] subset: goslim_chembl subset: goslim_pir synonym: "adhesive extracellular matrix constituent" RELATED [] synonym: "extracellular matrix constituent binding" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0050877 name: nervous system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio] comment: Discussion of class label and synonyms: https://github.com/geneontology/go-ontology/issues/13824 subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "neurological system process" EXACT [] synonym: "neurophysiological process" EXACT [] synonym: "pan-neural process" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051082 name: unfolded protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with an unfolded protein." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "binding unfolded ER proteins" NARROW [] synonym: "chaperone activity" RELATED [] synonym: "fimbrium-specific chaperone activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "histone-specific chaperone activity" RELATED [] synonym: "ribosomal chaperone activity" RELATED [] synonym: "tubulin-specific chaperone activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051186 name: cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "cofactor metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0051219 name: phosphoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated protein." [GOC:ai] subset: goslim_chembl synonym: "phosphorylated protein binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0051287 name: NAD binding namespace: molecular_function alt_id: GO:0051288 def: "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai] subset: goslim_chembl synonym: "NAD or NADH binding" RELATED [GOC:mah] synonym: "NAD+ or NADH binding" RELATED [] synonym: "nicotinamide adenine dinucleotide binding" EXACT [] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_generic subset: goslim_pir xref: Wikipedia:Cell_division is_a: GO:0008150 ! biological_process [Term] id: GO:0051400 name: BH domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Bcl-2 homology (BH) domain of a protein. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] subset: goslim_chembl synonym: "Bcl-2 homology domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0051428 name: peptide hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for peptide hormones." [GOC:ai] subset: goslim_chembl synonym: "polypeptide hormone receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0051434 name: BH3 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the BH3 domain of a protein of the Bcl-2 family. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death." [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] subset: goslim_chembl is_a: GO:0051400 ! BH domain binding [Term] id: GO:0051604 name: protein maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast is_a: GO:0008152 ! metabolic process relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0051992 name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13, MetaCyc:PHOSNACMURPENTATRANS-RXN] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: goslim_chembl xref: EC:2.7.8.13 xref: MetaCyc:PHOSNACMURPENTATRANS-RXN is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups created_by: gwg creation_date: 2010-07-06T12:10:01Z [Term] id: GO:0052654 name: L-leucine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN] subset: goslim_chembl synonym: "L-leucine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG:R01090 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN is_a: GO:0016740 ! transferase activity [Term] id: GO:0052655 name: L-valine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN] subset: goslim_chembl synonym: "L-valine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG:R01214 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN is_a: GO:0016740 ! transferase activity [Term] id: GO:0052656 name: L-isoleucine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid." [EC:2.6.1.42, MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN] subset: goslim_chembl synonym: "L-isoleucine aminotransferase activity" EXACT [] xref: EC:2.6.1.42 xref: KEGG:R02199 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN is_a: GO:0016740 ! transferase activity [Term] id: GO:0055036 name: virion membrane namespace: cellular_component def: "The lipid bilayer surrounding a virion." [GOC:jid, GOC:rph, PMID:213106] subset: goslim_chembl is_a: GO:0016020 ! membrane relationship: part_of GO:0019012 ! virion [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process def: "The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:dph, GOC:jid] comment: Transmembrane transport requires transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "membrane transport" EXACT [] xref: Reactome:REACT_100480 "SLC-mediated transmembrane transport, Taeniopygia guttata" xref: Reactome:REACT_101577 "SLC-mediated transmembrane transport, Caenorhabditis elegans" xref: Reactome:REACT_101877 "SLC-mediated transmembrane transport, Escherichia coli" xref: Reactome:REACT_101975 "SLC-mediated transmembrane transport, Sus scrofa" xref: Reactome:REACT_102348 "Transmembrane transport of small molecules, Staphylococcus aureus N315" xref: Reactome:REACT_102897 "Transmembrane transport of small molecules, Caenorhabditis elegans" xref: Reactome:REACT_102974 "SLC-mediated transmembrane transport, Canis familiaris" xref: Reactome:REACT_104555 "SLC-mediated transmembrane transport, Xenopus tropicalis" xref: Reactome:REACT_108243 "SLC-mediated transmembrane transport, Staphylococcus aureus N315" xref: Reactome:REACT_109832 "Transmembrane transport of small molecules, Plasmodium falciparum" xref: Reactome:REACT_110770 "ABC-family proteins mediated transport, Mus musculus" xref: Reactome:REACT_114546 "ABC-family proteins mediated transport, Staphylococcus aureus N315" xref: Reactome:REACT_114763 "ABC-family proteins mediated transport, Escherichia coli" xref: Reactome:REACT_114890 "ABC-family proteins mediated transport, Plasmodium falciparum" xref: Reactome:REACT_115378 "ABC-family proteins mediated transport, Mycobacterium tuberculosis" xref: Reactome:REACT_15480 "ABC-family proteins mediated transport, Homo sapiens" xref: Reactome:REACT_15518 "Transmembrane transport of small molecules, Homo sapiens" xref: Reactome:REACT_19118 "SLC-mediated transmembrane transport, Homo sapiens" xref: Reactome:REACT_29093 "ABC-family proteins mediated transport, Taeniopygia guttata" xref: Reactome:REACT_29184 "SLC-mediated transmembrane transport, Gallus gallus" xref: Reactome:REACT_29635 "Transmembrane transport of small molecules, Canis familiaris" xref: Reactome:REACT_30969 "ABC-family proteins mediated transport, Canis familiaris" xref: Reactome:REACT_32055 "Transmembrane transport of small molecules, Saccharomyces cerevisiae" xref: Reactome:REACT_32223 "Transmembrane transport of small molecules, Rattus norvegicus" xref: Reactome:REACT_32423 "SLC-mediated transmembrane transport, Bos taurus" xref: Reactome:REACT_32713 "ABC-family proteins mediated transport, Sus scrofa" xref: Reactome:REACT_33571 "SLC-mediated transmembrane transport, Danio rerio" xref: Reactome:REACT_61245 "Transmembrane transport of small molecules, Bos taurus" xref: Reactome:REACT_79086 "SLC-mediated transmembrane transport, Plasmodium falciparum" xref: Reactome:REACT_79921 "SLC-mediated transmembrane transport, Saccharomyces cerevisiae" xref: Reactome:REACT_80022 "ABC-family proteins mediated transport, Bos taurus" xref: Reactome:REACT_80510 "ABC-family proteins mediated transport, Rattus norvegicus" xref: Reactome:REACT_80848 "ABC-family proteins mediated transport, Schizosaccharomyces pombe" xref: Reactome:REACT_80977 "ABC-family proteins mediated transport, Caenorhabditis elegans" xref: Reactome:REACT_81024 "Transmembrane transport of small molecules, Oryza sativa" xref: Reactome:REACT_81153 "SLC-mediated transmembrane transport, Mus musculus" xref: Reactome:REACT_82725 "SLC-mediated transmembrane transport, Rattus norvegicus" xref: Reactome:REACT_83770 "Transmembrane transport of small molecules, Escherichia coli" xref: Reactome:REACT_86135 "ABC-family proteins mediated transport, Oryza sativa" xref: Reactome:REACT_86409 "Transmembrane transport of small molecules, Drosophila melanogaster" xref: Reactome:REACT_86576 "Transmembrane transport of small molecules, Schizosaccharomyces pombe" xref: Reactome:REACT_87124 "SLC-mediated transmembrane transport, Oryza sativa" xref: Reactome:REACT_88059 "ABC-family proteins mediated transport, Xenopus tropicalis" xref: Reactome:REACT_88521 "Transmembrane transport of small molecules, Taeniopygia guttata" xref: Reactome:REACT_88894 "Transmembrane transport of small molecules, Gallus gallus" xref: Reactome:REACT_89376 "SLC-mediated transmembrane transport, Schizosaccharomyces pombe" xref: Reactome:REACT_91272 "ABC-family proteins mediated transport, Arabidopsis thaliana" xref: Reactome:REACT_91803 "SLC-mediated transmembrane transport, Mycobacterium tuberculosis" xref: Reactome:REACT_92006 "Transmembrane transport of small molecules, Mycobacterium tuberculosis" xref: Reactome:REACT_92624 "ABC-family proteins mediated transport, Gallus gallus" xref: Reactome:REACT_93747 "Transmembrane transport of small molecules, Dictyostelium discoideum" xref: Reactome:REACT_94160 "Transmembrane transport of small molecules, Mus musculus" xref: Reactome:REACT_94393 "ABC-family proteins mediated transport, Drosophila melanogaster" xref: Reactome:REACT_94944 "ABC-family proteins mediated transport, Danio rerio" xref: Reactome:REACT_94972 "SLC-mediated transmembrane transport, Dictyostelium discoideum" xref: Reactome:REACT_96633 "Transmembrane transport of small molecules, Sus scrofa" xref: Reactome:REACT_96636 "SLC-mediated transmembrane transport, Arabidopsis thaliana" xref: Reactome:REACT_97365 "Transmembrane transport of small molecules, Arabidopsis thaliana" xref: Reactome:REACT_97867 "ABC-family proteins mediated transport, Saccharomyces cerevisiae" xref: Reactome:REACT_98509 "Transmembrane transport of small molecules, Xenopus tropicalis" xref: Reactome:REACT_98716 "SLC-mediated transmembrane transport, Drosophila melanogaster" xref: Reactome:REACT_99579 "Transmembrane transport of small molecules, Danio rerio" xref: Reactome:REACT_99829 "ABC-family proteins mediated transport, Dictyostelium discoideum" is_a: GO:0006810 ! transport [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 alt_id: GO:0044802 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "cellular membrane organisation" EXACT [GOC:curators] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] synonym: "single-organism membrane organization" RELATED [] xref: Reactome:REACT_101524 "Membrane Trafficking, Dictyostelium discoideum" xref: Reactome:REACT_103082 "Membrane Trafficking, Schizosaccharomyces pombe" xref: Reactome:REACT_11123 "Membrane Trafficking, Homo sapiens" xref: Reactome:REACT_29278 "Membrane Trafficking, Sus scrofa" xref: Reactome:REACT_32337 "Membrane Trafficking, Taeniopygia guttata" xref: Reactome:REACT_33741 "Membrane Trafficking, Bos taurus" xref: Reactome:REACT_34084 "Membrane Trafficking, Caenorhabditis elegans" xref: Reactome:REACT_78213 "Membrane Trafficking, Plasmodium falciparum" xref: Reactome:REACT_78288 "Membrane Trafficking, Xenopus tropicalis" xref: Reactome:REACT_83546 "Membrane Trafficking, Oryza sativa" xref: Reactome:REACT_86557 "Membrane Trafficking, Arabidopsis thaliana" xref: Reactome:REACT_87431 "Membrane Trafficking, Drosophila melanogaster" xref: Reactome:REACT_88307 "Membrane Trafficking, Mus musculus" xref: Reactome:REACT_91154 "Membrane Trafficking, Saccharomyces cerevisiae" xref: Reactome:REACT_93714 "Membrane Trafficking, Danio rerio" xref: Reactome:REACT_95586 "Membrane Trafficking, Gallus gallus" xref: Reactome:REACT_96516 "Membrane Trafficking, Canis familiaris" xref: Reactome:REACT_97881 "Membrane Trafficking, Rattus norvegicus" is_a: GO:0008150 ! biological_process created_by: janelomax creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0065003 name: protein-containing complex assembly namespace: biological_process alt_id: GO:0006461 def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "chaperone activity" RELATED [] synonym: "macromolecular complex assembly" RELATED [] synonym: "macromolecule complex assembly" RELATED [] synonym: "protein complex assembly" RELATED [] synonym: "protein complex formation" RELATED [] is_a: GO:0022607 ! cellular component assembly [Term] id: GO:0070290 name: N-acylphosphatidylethanolamine-specific phospholipase D activity namespace: molecular_function def: "Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE)." [GOC:elh, PMID:14634025, PMID:15878693] subset: goslim_chembl synonym: "N-acyl-phosphatidylethanolamine-specific phospholipase D activity" EXACT [] synonym: "NAPE-specific phospholipase D activity" EXACT [] xref: EC:3.1.4.4 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0070324 name: thyroid hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland." [GOC:rph] subset: goslim_chembl synonym: "thyroxine binding" NARROW [GOC:mah] synonym: "triiodothyronine binding" NARROW [GOC:mah] is_a: GO:0042562 ! hormone binding [Term] id: GO:0070628 name: proteasome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation." [GOC:mah] subset: goslim_chembl is_a: GO:0044877 ! protein-containing complex binding created_by: midori creation_date: 2009-05-01T04:38:58Z [Term] id: GO:0070976 name: TIR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components." [GOC:mah, InterPro:IPR000157] subset: goslim_chembl synonym: "Toll-Interleukin receptor domain binding" EXACT [InterPro:IPR000157] is_a: GO:0019904 ! protein domain specific binding created_by: midori creation_date: 2009-10-02T01:17:29Z [Term] id: GO:0070989 name: oxidative demethylation namespace: biological_process def: "The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate." [GOC:BHF, GOC:mah, GOC:rl] subset: goslim_chembl is_a: GO:0008152 ! metabolic process created_by: midori creation_date: 2009-10-29T03:33:25Z [Term] id: GO:0071554 name: cell wall organization or biogenesis namespace: biological_process alt_id: GO:0070882 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular cell wall organization or biogenesis" EXACT [] is_a: GO:0008150 ! biological_process created_by: midori creation_date: 2010-01-13T03:19:38Z [Term] id: GO:0071941 name: nitrogen cycle metabolic process namespace: biological_process def: "A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization." [GOC:mah, PMID:16675690, Wikipedia:Nitrogen_cycle] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe xref: Wikipedia:Nitrogen_cycle is_a: GO:0008152 ! metabolic process created_by: midori creation_date: 2010-09-30T05:21:03Z [Term] id: GO:0140014 name: mitotic nuclear division namespace: biological_process def: "A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic is_a: GO:0008150 ! biological_process relationship: part_of GO:0000278 ! mitotic cell cycle created_by: pg creation_date: 2017-03-23T14:44:23Z [Typedef] id: ends_during name: ends_during namespace: external xref: RO:0002093 [Typedef] id: happens_during name: happens_during namespace: external xref: RO:0002092 is_transitive: true is_a: ends_during ! ends_during [Typedef] id: has_part name: has_part namespace: external xref: BFO:0000051 is_transitive: true [Typedef] id: negatively_regulates name: negatively regulates namespace: external xref: RO:0002212 is_a: regulates ! regulates transitive_over: part_of ! part of [Typedef] id: never_in_taxon name: never_in_taxon namespace: external xref: RO:0002161 expand_assertion_to: "Class: ?X DisjointWith: RO_0002162 some ?Y" [] is_metadata_tag: true is_class_level: true [Typedef] id: occurs_in name: occurs in namespace: external xref: BFO:0000066 holds_over_chain: part_of occurs_in transitive_over: part_of ! part of [Typedef] id: part_of name: part of namespace: external xref: BFO:0000050 is_transitive: true inverse_of: has_part ! has_part [Typedef] id: positively_regulates name: positively regulates namespace: external xref: RO:0002213 holds_over_chain: negatively_regulates negatively_regulates is_a: regulates ! regulates transitive_over: part_of ! part of [Typedef] id: regulates name: regulates namespace: external xref: RO:0002211 is_transitive: true transitive_over: part_of ! part of [Typedef] id: starts_during name: starts_during namespace: external xref: RO:0002091